Combined therapy of 5-aminolevulinic acid photodynamic therapy and intense pulsed light for rosacea

Bao, Naijia; Gu, TianShu; Zeng, Jinshan; Wu, Yan; Sun, Yan; Gao, Xing‐Hua; Chen, HongDuo

doi:10.1007/s10103-022-03685-y

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Something that is noteworthy is that another emerging procedural therapy for both erythemato-telangiectatic and papulopustular rosacea is topical photodynamic therapy with 5-aminolevulinic acid (ALA-PDT). It has proved to be safe and effective [107], also in combination with IPL [108]. Lastly, two sessions of fractional microneedling radiofrequency (FMR) treatment at 4-week intervals showed modest improvement in erythema, and it might be used as an alternative or in combination with other treatment methods [109].…”

Section: Transient/persistent Centrofacial Erythema and Telangiectasiamentioning

confidence: 99%

Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach

Galluccio,

D’Onghia,

Malvaso

et al. 2024

Cosmetics

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Rosacea is a common chronic inflammatory skin disorder that mainly affects the central face. It is primarily characterized by recurrent episodes of flushing, persistent erythema, inflammatory papules, telangiectasias, phymatous changes, and ocular symptoms. Its pathogenesis is complex and still not completely understood. It encompasses innate and adaptive immune system dysregulation, neurovascular dysfunction, and genetic and environmental factors. To date, four subtypes of rosacea have been identified, based on the predominant clinical features: erythemato-teleangiectatic, papulopustular, pyhomatous, and ocular rosacea. New insights into this condition have led to several pharmacological treatments, including topical medications, spanning from the conventional azelaic acid, metronidazole, benzoyl peroxide, clindamycin, and erythromycin to new ones including not only brimonidine, oxymetazoline, ivermectine, and minocycline but also systemic drugs such as oral antibiotics, isotretinoin, non-selective β-blockers or α2-adrenergic agonists, and laser- or light-based therapies, together with new therapeutic approaches. The aim of this study was to review the current literature on the pathophysiology of rosacea and to provide an overview of therapeutic approaches that specifically address each clinical subtype.

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Section: Transient/persistent Centrofacial Erythema and Telangiectasiamentioning

confidence: 99%

Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach

Galluccio,

D’Onghia,

Malvaso

et al. 2024

Cosmetics

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“…Recent randomized controlled trials with larger sample sizes have reported improved treatment efficacy and milder adverse reactions when PDT is combined with other modalities, such as 1550 nm fractional therapy laser or Danzhi Xiaoyao Powder [ 268 , 269 ]. In a single-arm trial involving 10 patients with ETR or PPR, PDT in combination with IPL also demonstrated favorable treatment outcomes and high patient satisfaction [ 270 ]. However, further research is needed to understand the treatment mechanisms, optimize the protocols, and determine long-term safety and efficacy.…”

Section: Treatmentsmentioning

confidence: 99%

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chen,

Wang,

Zhang

et al. 2023

Biomedicines

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Rosacea is a chronic inflammatory skin disease characterized by recurrent erythema, flushing, telangiectasia, papules, pustules, and phymatous changes in the central area of the face. Patients with this condition often experience a significant negative impact on their quality of life, self-esteem, and overall well-being. Despite its prevalence, the pathogenesis of rosacea is not yet fully understood. Recent research advances are reshaping our understanding of the underlying mechanisms of rosacea, and treatment options based on the pathophysiological perspective hold promise to improve patient outcomes and reduce incidence. In this comprehensive review, we investigate the pathogenesis of rosacea in depth, with a focus on emerging and novel mechanisms, and provide an up-to-date overview of therapeutic strategies that target the diverse pathogenic mechanisms of rosacea. Lastly, we discuss potential future research directions aimed at enhancing our understanding of the condition and developing effective treatments.

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“…4 In addition, laser therapy is also used to eliminate erythema and telangiectasia. 5,6 Ozone medical preparations are mainly divided into ozonated hydrotherapy, ozone oil for externally use, and ozone autohemotherapy (OAHT). Currently, the application of ozone therapy in dermatology lacks the support of sufficient theoretical basis and clinical data.…”

Section: Introductionmentioning

confidence: 99%

Ozonated Hydrotherapy Combined with LED Yellow Light Irradiation and Oral Minocycline Treatment for Mild to Moderate Papulopustular Rosacea: A Comparative Retrospective Study

Wei,

Zhang,

Leng

et al. 2024

CCID

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The treatment of recurrent rosacea has always been a problem. Oral minocycline has been widely used in the treatment of rosacea. However, the efficacy and safety of ozonated hydrotherapy combined with LED yellow light irradiation and oral minocycline for mild to moderate papulopustular rosacea (PPR) has not been thoroughly studied. Methods: Patients with rosacea who met the criteria and had complete clinical statistic admitted to our hospital from April 2021 to September 2022 were retrospectively collected and divided into combined therapy group and oral only group. The patients in the two groups were treated with minocycline for 8 weeks. In addition, the patients in combined therapy group were treated with ozone hydrotherapy once a week, followed by LED yellow light irradiation for a total of 4 weeks. The Investigator' s global assessment (IGA) score was used to assess the condition. The efficacy was evaluated using the patients' subjective symptom scores. Skin lesion images and adverse reactions were recorded. The recurrence rate was observed after 24 weeks of follow-up. Results: A total of 39 patients included in the study. After 4 weeks of treatment, the effective rate was 90% in combined therapy group and 52.63% in oral only group (p<0.05). After 8 weeks of treatment, the total score of the patients' subjective symptom scores and the scores of itching and burning sensation in combined therapy group were lower than those in oral only group (p<0.05). After 24 weeks of follow-up, the recurrence rate of combined therapy group was 5%, and that of oral only group was 26.32%. The mild adverse reactions experienced by both groups disappeared during follow-up. Conclusion:This combination therapy has a significant, rapid and safe therapeutic effect, especially in relieving itching and burning sensations, and may reduce the recurrence rate.

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Combined therapy of 5-aminolevulinic acid photodynamic therapy and intense pulsed light for rosacea

Cited by 4 publications

References 25 publications

Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach

Advances in the Pathogenesis and Treatment of Rosacea: A Phenotype-Based Therapeutic Approach

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Ozonated Hydrotherapy Combined with LED Yellow Light Irradiation and Oral Minocycline Treatment for Mild to Moderate Papulopustular Rosacea: A Comparative Retrospective Study

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