Combined toxicity of endosulfan and ochratoxin-A in rats: histopathological changes

Abstract

The aim of this study was to examine and compare the toxic effects of endosulfan and ochratoxin-A (OTA), individually and in combination, in adult male rats with respect to histopathological changes over 30 days of treatment. Adult male Wistar rats were randomly allotted to four groups (individual treatments, combination and control) of 10 rats each and fed OTA @ 4 ppm in feed (Group-I), endosulfan @ 5 mg/kg BW in corn oil by oral gavage (Group-II), and endosulfan with OTA in combination (Group-III) daily for 30 days. Group IV was kept as control and fed toxin free feed. After 30 days of treatment, tissues were collected in 10% buffered formalin for histopathological studies. The hematoxylin and eosin stained paraffin sections showed varying degree of degenerative and necrotic changes in kidneys and liver which were more severe in OTA treated rats in comparison to endosulfan fed group. However, the changes observed in group III rats, which received both OTA and endosulfan were even more pronounced than those observed in rats fed OTA or endosulfan alone. The present findings suggest that OTA and endosulfan had additive effects which may play an important role in pathogenesis.

Combination of fluoride and endosulfan induced teratogenicity and developmental toxicity in Swiss albino mice exposed during organogenesis

“…Presence of completely malformed fetuses only in combination group also indicates combined teratogenic susceptibility of fluoride and endosulfan. Similarly, ochratoxin-A and endosulfan were found to be potentially more toxic to kidney and liver in combination as compared to their toxic effects alone (Kumar et al, 2015). Also exposure to mixture of endosulfan or cypermethrin but not individual pesticide, impaired associative learning in females and spatial memory in males and also increased motor activity in males and females (Giménez et al, 2018).…”

The Effect of Garlic Volatile Oil Supplementation on Illeum Histologic of Extensive System Cihateup Duck

“…Atsiri mencegah stress oksidatif sehingg dapat pertumbuhan yang tinggi bagi jaringanjaringan di abdomen maupun jaringan otot. Hasil penelitian lain menunjukkan bahwa pertumbuhan jaringan yang tinggi sebagai dampak pemberian bahan aktif seperti atsiri juga disebebakan oleh menunrunnya resiko inflamasi sel-sel (Sirovina et al, 2013;McManaman et al, 2014dan Chatterjee et al, 2015, menurunnya radikal bebas dari stres oksidatif (Korivi et al, 2012;Bertaggia et al, 2014); juga karena menurunnya apoptosis atau kematian sel-sel sehingga metabolisme jaringan menjadi optimal (Liu et al, 2010;Kumar et al, 2015).…”

HISTOLOGI LIVER BURUNG PUYUH DENGAN PEMBERIAN MINYAK ATSIRI BAWANG PUTIH (Liver Histologic of Quail with Administeration of Garlic Volatile Oil)

“…Terkait dampak radikal bebas, Yarrus et al (2009); Arya dkk. (2014) dan Lai et al (2014), Chatterjee et al (2015) mengemukakan bahwa sintesis protein dan lipid dapat mengalami penurunan dengan tajam sebagai dampak senyawa-senyawa radikal, juga dilaporkan terjadi peningkatan kerusakan jaringan (Burdick et al, 2011;Mohanty et al, 2015;Lee et al, 2014;Adriani et al, 2015); peningkatan kematian sel (Kumar et al, 2015), serta mutasi dan kerusakan DNA (Bertaggia et al, 2014). Minyak atsiri mampu mencegah stress oksidatif dan kerusakan yang ditimbulkan oleh senyawa radikal, sehingga menyebabkan perbaikan sel bagi jaringan-jaringan di abdomen maupun jaringan otot.…”

“…Minyak atsiri mampu mencegah stress oksidatif dan kerusakan yang ditimbulkan oleh senyawa radikal, sehingga menyebabkan perbaikan sel bagi jaringan-jaringan di abdomen maupun jaringan otot. Hasil penelitian lain menunjukkan bahwa pertumbuhan jaringan yang tinggi sebagai dampak pemberian bahan aktif seperti atsiri juga disebabkan oleh menurunnya resiko inflamasi sel-sel (Sirovina et al, 2013;McManaman et al, 2014dan Chatterjee et al, 2015, menurunnya radikal bebas dari stres oksidatif (Korivi et al, 2012;Bertaggia et al, 2014); juga karena menurunnya apoptosis atau kematian sel-sel sehingga metabolisme jaringan menjadi optimal (Liu et al, 2010;Kumar et al, 2015).…”