Combined toxicity of methanol and formic acid: two cases of methanol poisoning

Kinoshita, Hiroaki; Ijiri, Iwao; Ameno, Setsuko; Tanaka, Naoki; Kubota, Toru; Tsujinaka, Masatake; Watanabe, Ryuichi; Ameno, Kiyoshi

doi:10.1016/s1353-1131(99)90088-3

Cited by 3 publications

(4 citation statements)

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“…The cut-off value for alcohol detection was 0.1 mg/ mL. 14 Sample information (including age, sex, cause of death, organ disease, mental disorder, occupation, traffic accident, type of death, environmental factors, type of drug, and alcohol concentration) was collected based on postmortem pathological examination, postmortem biochemistry findings, toxicological findings, and information obtained from investigations conducted by the authorities. Blood alcohol concentrations were determined using headspace gas chromatography/mass spectrometry.…”

Section: Study Variable Definitionsmentioning

confidence: 99%

Problems in Social Medicine Related to Alcohol and Deaths: Autopsy Cases in the Southern Part of Osaka City

Tani¹,

Ikeda²,

Hirokawa³

et al. 2021

SAR

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The purpose of this study was to examine the social and medical background of alcohol dependence and to prevent the abuse of alcohol. Methods: Alcohol and deaths were retrospectively investigated based on the forensic postmortem data of 1694 decedents ≥20 years of age in 2008-2017. Of these, the 999 cases that could be tested for alcohol within 48 h of death were examined. Results:The alcohol-positive and alcohol-negative groups included 179 (17.9%) and 820 (82.1%) cases, respectively. In terms of medical issues, compared with the alcohol-negative group, men in the positive group were mostly in their 40s to 60s, whereas women's age peaked in the 70s. The causes of death included many blunt injuries in men, though there was no difference in women. Underlying diseases were more frequent in men than women, with many of them having heart or liver disease, and the percentage of cases with mental disorders was 16.8% in the alcohol-positive group. In 15 cases of the alcohol-positive group, phenothiazine and barbituric acids were detected in 53.3% and 46.7% of cases, respectively. The incidence of traffic accidents and homicides was higher in the alcohol-positive group than in the alcohol-negative group. Conclusion: Measures to address social issues based on risk factors for alcohol and deaths are required.

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Section: Study Variable Definitionsmentioning

confidence: 99%

Problems in Social Medicine Related to Alcohol and Deaths: Autopsy Cases in the Southern Part of Osaka City

Tani¹,

Ikeda²,

Hirokawa³

et al. 2021

SAR

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“…Drinking of this adulterated beverage instead of pure ethanol leads to methanol poisoning and if not diagnosed and treated results in high mortality rate. There is evidence that methanol poisoning is due to its conversion to highly toxic metabolites, formaldehyde and formic acid (Kinoshita et al, 1998;Skrzydlewska, 2003). Severe metabolic acidosis induced by formic acid leads to death (Azmak, 2006;Kinoshita et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…There is evidence that methanol poisoning is due to its conversion to highly toxic metabolites, formaldehyde and formic acid (Kinoshita et al, 1998;Skrzydlewska, 2003). Severe metabolic acidosis induced by formic acid leads to death (Azmak, 2006;Kinoshita et al, 1998). Methanol and ethanol metabolisms show similarities.…”

Section: Introductionmentioning

confidence: 99%

Fatal methanol poisoning

et al. 2011

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Methanol poisoning has become a considerable problem in Iran. Liver can show some features of poisoning after methanol ingestion. Therefore, our concern was to examine liver tissue histopathology in fatal methanol poisoning cases in Iranian population. In this study, 44 cases of fatal methanol poisoning were identified in a year. The histological changes of the liver were reviewed. The most striking features of liver damage by light microscopy were micro-vesicular steatosis, macro-vesicular steatosis, focal hepatocyte necrosis, mild intra-hepatocyte bile stasis, feathery degeneration and hydropic degeneration. Blood and vitreous humor methanol concentrations were examined to confirm the proposed history of methanol poisoning. The majority of cases were men (86.36%). In conclusion, methanol poisoning can cause histological changes in liver tissues. Most importantly in cases with mean blood and vitreous humor methanol levels greater than 127 ± 38.9 mg/dL more than one pathologic features were detected.

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“…The toxicity of methanol is because of its metabolites, formaldehyde and formic acid (formate), and further to carbon dioxide and water. Formic acid induces severe metabolic acidosis that leads to death and is the primary agent responsible for the ocular toxicity (8–10). Formaldehyde is highly toxic but has a short half‐life and does not accumulate (11).…”

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confidence: 99%

Methyl Alcohol Poisoning in Trabzon (Turkey)

Karadeniz

Birincioğlu

2011

Journal of Forensic Sciences

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The aim of this retrospective study was to examine methyl alcohol intoxications in Trabzon (Turkey) and to determine any relations between the laboratory results and histopathologic changes. A total of 4492 forensic autopsies were performed from 1998 to 2008. Thirteen of the cases (0.3%) were because of methanol poisoning, and all were men. Their ages ranged from 25 to 62 years. The blood methanol concentrations ranged widely, from 15 to 482 mg/dL. In six cases, poisoning was because of consumption of the alcoholic beverage "Raki," while in five cases, poisoning was because of the ingestion of cologne. The products consumed were unknown in the other two cases because of insufficient history and data records. Mortality because of methanol poisoning may be prevented/decreased with the implementation of some precautions, such as public education regarding the harms of methyl alcohol, routine monitoring of the vendors that sell alcoholic beverages and cologne, and appropriate legal retribution for the illegal production of methanol.

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Combined toxicity of methanol and formic acid: two cases of methanol poisoning

Cited by 3 publications

References 0 publications

Problems in Social Medicine Related to Alcohol and Deaths: Autopsy Cases in the Southern Part of Osaka City

Problems in Social Medicine Related to Alcohol and Deaths: Autopsy Cases in the Southern Part of Osaka City

Fatal methanol poisoning

Methyl Alcohol Poisoning in Trabzon (Turkey)

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