Combined Traumatic Brain Injury and Hemorrhagic Shock in Ferrets Leads to Structural, Neurochemical, and Functional Impairments

Goodfellow, Molly J.; Medina, Juliana; Proctor, Julie L.; Xu, Su; Gullapalli, Rao P.; Rangghran, Parisa; Miller, Catriona; Vesselinov, Alexandra; Fiskum, Gary

doi:10.1089/neu.2022.0102

Cited by 6 publications

(6 citation statements)

References 33 publications

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“…A variety of preclinical models have been created to investigate this challenging issue. They differ in modeling TBI, hemorrhage, and animal species used [ 33 , 61 , 62 , 65 , 66 , 67 ]. Blast injury is a typical military medical condition.…”

Section: Discussionmentioning

confidence: 99%

Immunopathological Alterations after Blast Injury and Hemorrhage in a Swine Model of Prolonged Damage Control Resuscitation

Simovic

Yang

Jordan

et al. 2023

IJMS

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Trauma-related hemorrhagic shock (HS) remains a leading cause of death among military and civilian trauma patients. We have previously shown that administration of complement and HMGB1 inhibitors attenuate morbidity and mortality 24 h after injury in a rat model of blast injury (BI) and HS. To further validate these results, this study aimed to develop a swine model and evaluate BI+HS-induced pathophysiology. Anesthetized Yucatan minipigs underwent combined BI and volume-controlled hemorrhage. After 30 min of shock, animals received an intravenous bolus of PlasmaLyte A and a continuous PlasmaLyte A infusion. The survival rate was 80% (4/5), and the non-survivor expired 72 min post-BI. Circulating organ-functional biomarkers, inflammatory biomarkers, histopathological evaluation, and CT scans indicated evidence of multiple-organ damage, systemic innate immunological activation, and local tissue inflammation in the injured animals. Interestingly, a rapid and dramatic increase in plasma levels of HMGB1 and C3a and markedly early myocarditis and encephalitis were associated with early death post-BI+HS. This study suggests that this model reflects the immunopathological alterations of polytrauma in humans during shock and prolonged damage control resuscitation. This experimental protocol could be helpful in the assessment of immunological damage control resuscitation approaches during the prolonged care of warfighters.

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Section: Discussionmentioning

confidence: 99%

Immunopathological Alterations after Blast Injury and Hemorrhage in a Swine Model of Prolonged Damage Control Resuscitation

Simovic

Yang

Jordan

et al. 2023

IJMS

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“…Like many higher mammals, ferrets have a gyrencephalic brain, demonstrate a high proportion of white matter (Schwerin et al , 2017), and their visual cortices exhibit ocular and orientation-selectively columns (Issa et al , 1999;Medinaet al , 2005). As a consequence, ferrets have been used to examine amblyopia (Liao et al , 2004;Krahe et al , 2005) or crossmodal plasticity (Roe et al , 1990) as well as in neuropsychiatric and neurologic conditions such as Fetal Alcohol Spectrum Disorders (Medina et al , 2003;Medina et al , 2005;Paul et al , 2010;Keum et al , 2023), TBI (Schwerin et al , 2017;Goodfellow et al , 2022) and cortical dysplasia (Noctor et al , 1999;Abbah & Juliano, 2014). The cortical location of the PPr is depicted on the lateral view of the ferret brain shown in Figure 1A.…”

Section: Introductionmentioning

confidence: 99%

Development of Multisensory Processing in Ferret Parietal Cortex.

Medina

Foxworthy

Keum

et al. 2023

Preprint

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It is well known that the nervous system adjusts itself to its environment during development. Although a great deal of effort has been directed toward understanding the developmental processes of the individual sensory systems (e.g., vision, hearing, etc.), only one major study has examined the maturation of multisensory processing of cortical neurons. Therefore, the present investigation sought to evaluate multisensory development in a different cortical region and species. Using multiple single-unit recordings in anesthetized ferrets (n=18) of different ages (from postnatal day 80 through 300), we studied the responses of neurons from the rostral posterior parietal area (PPr) to presentations of visual, tactile and combined visual-tactile stimulation. The results showed that multisensory neurons were infrequent at the youngest ages (pre-pubertal) and progressively increased through the later ages. Significant response changes that result from multisensory stimulation (defined as multisensory integration, MSI) were observed in post-pubertal adolescent animals and the magnitude of these integrated responses also increased across this age group. Furthermore, non-significant multisensory response changes were progressively increased in adolescent animals. Collectively, at the population level, MSI was observed to shift from primarily suppressive levels in infants to increasingly higher levels in later stages. These data indicate that, like the unisensory systems from which it is derived, multisensory processing shows developmental changes the specific time course of which may be regionally and species dependent.

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“…Like many higher mammals, ferrets have a gyrencephalic brain, demonstrate a high proportion of white matter (Schwerin et al, 2017), and their visual cortices exhibit ocular and orientation‐selective columns (Issa et al, 1999; Medina et al, 2005). As a consequence, ferrets have been used to examine amblyopia (Krahe et al, 2005; Liao et al, 2004) or crossmodal plasticity (Roe et al, 1990), as well as neuropsychiatric and neurologic conditions such as foetal alcohol spectrum disorders (Keum et al, 2023; Medina et al, 2003; Medina et al, 2005; Medina et al, 2006; Paul et al, 2010), traumatic brain injury (Goodfellow et al, 2022; Schwerin et al, 2017) and cortical dysplasia (Abbah & Juliano, 2014; Noctor et al, 1999). The ferret model has also been used to study parietal cortical function, which, in humans, is involved in attention, rectification of spatial maps, goal‐directed behaviours, visual‐somatosensory integration during reaching movements and self‐awareness (Alais et al, 2010; Andersen & Buneo, 2002; Blanke, 2012; Calton & Taube, 2009; Kaas et al, 2011; Nitz, 2009; Reep & Corwin, 2009; Save & Poucet, 2009).…”

Section: Introductionmentioning

confidence: 99%

Development of multisensory processing in ferret parietal cortex

Medina

Foxworthy

Keum

et al. 2023

Eur J of Neuroscience

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It is well known that the nervous system adjusts itself to its environment during development. Although a great deal of effort has been directed towards understanding the developmental processes of the individual sensory systems (e.g., vision, hearing, etc.), only one major study has examined the maturation of multisensory processing in cortical neurons. Therefore, the present investigation sought to evaluate multisensory development in a different cortical region and species. Using multiple single‐unit recordings in anaesthetised ferrets (n = 18) of different ages (from postnatal day 80 to 300), we studied the responses of neurons from the rostral posterior parietal (PPr) area to presentations of visual, tactile and combined visual‐tactile stimulation. The results showed that multisensory neurons were infrequent at the youngest ages (pre‐pubertal) and progressively increased through the later ages. Significant response changes that result from multisensory stimulation (defined as multisensory integration [MSI]) were observed in post‐pubertal adolescent animals, and the magnitude of these integrated responses also increased across this age group. Furthermore, non‐significant multisensory response changes were progressively increased in adolescent animals. Collectively, at the population level, MSI was observed to shift from primarily suppressive levels in infants to increasingly higher levels in later stages. These data indicate that, like the unisensory systems from which it is derived, multisensory processing shows developmental changes whose specific time course may be regionally and species‐dependent.

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Combined Traumatic Brain Injury and Hemorrhagic Shock in Ferrets Leads to Structural, Neurochemical, and Functional Impairments

Cited by 6 publications

References 33 publications

Immunopathological Alterations after Blast Injury and Hemorrhage in a Swine Model of Prolonged Damage Control Resuscitation

Immunopathological Alterations after Blast Injury and Hemorrhage in a Swine Model of Prolonged Damage Control Resuscitation

Development of Multisensory Processing in Ferret Parietal Cortex.

Development of multisensory processing in ferret parietal cortex

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