Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

He, Chuanchao; Zhang, Kun‐He; Li, Qing; Liu, Xiaohua; Hong, Yan; Lv, Nonghua

doi:10.1186/1471-230x-13-87

Cited by 159 publications

(100 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results in the present study were similar to those previously obtained: In a systematic review (9) of 187 publications with data for CEA and CA19-9, and 19 publications with data for CEA, CA72-4 and CA19-9, the positive rates were 21.1% for CEA, 27.8% for CA19-9 and 30.0% for CA72-4. In a study of 149 Chinese patients with GC, He et al (10) demonstrated that the positive rates for CEA and CA19-9 were 17.4 and 20.8%, respectively, which were not significantly different. In a subsequent study of Chinese patients with GC, the preoperative serum positive rate of CEA was 24.0%, which was similar to the serum positive rate of CA19-9 (18.9%) (21).…”

Section: Discussionmentioning

confidence: 95%

“…However, the specificity and sensitivity of serum tumor markers considered in isolation are not satisfactory in GC, particularly in the early stage (9). Therefore, certain researchers have previously used combinations of markers, since they can improve the sensitivity for diagnosis of GC (10)(11)(12). Yang et al (13) demonstrated that the sensitivities of CA72-4, CEA, cancer antigen 125 (CA125) and CA19-9 for GC were 33.0, 25.5, 31.1 and 38.7%, respectively.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

Zhang

Zhao

2015

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. The sensitivity of three biomarkers, carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 and CA72-4, in combination has been identified to be greater than that of any of the biomarkers considered in isolation in cases of gastric cancer (GC). However, the fundamental cause underlying this phenomenon remains to be fully elucidated. In the present study, the differences and correlation of these three biomarkers were investigated in patients with GC in order to determine how the three biomarkers in combination work more effectively compared with any of the biomarkers considered alone. The serum levels of CEA, CA19-9 and CA72-4 of 216 patients with gastric adenocarcinoma were analyzed on admission to hospital. The differences in positive rates and the serum levels of CEA, CA19-9 and CA72-4 were analyzed using the χ 2 test and the non-parametric Wilcoxon two-sample test. Phi (f) correlation analysis was used to study the correlation among the expression (positive or not) levels of CEA, CA19-9 and CA72-4. The correlation among the serum levels of biomarkers was analyzed using Spearman's test. The results demonstrated that the combined positive rate of CEA, CA19-9 and CA72-4 was significantly higher compared with the individual CEA, CA19-9 and CA72-4 positive rates (44.91% vs. 22.69, 18.98 and 22.69%, respectively; all P<0.05). The positive rate of CA19-9 and CA72-4 in the extent of the primary tumor/involvement of regional lymph node/distant metastases (TNM)-III/IV stage subgroup was higher compared with that in the TNM-I/II subgroup (χ 2 =5.902, P=0.015; χ 2 =8.009, P=0.005), although not the positive rate of CEA (χ 2 =0.302, P= 0.583). A significant correlation was identified between the expression level of CEA and CA72-4 (f correlation coefficient=0.182; P=0.008) and between that of CA19-9 and CA72-4 (f correlation coefficient= 0.189; P= 0.006), although not between that of CEA and CA19-9 (f correlation coefficient=0.048; P=0.482) in the total number of patients with GC. A significant correlation was also identified between the serum levels of CEA and CA19-9, of CEA and CA72-4 and of CA19-9 and CA72-4 (Spearman's correlation coefficient=0.231, -0.271 and 0.167; P=0.001, P<0.0001 and P=0.014, respectively). The present study indicated that there was only a weak correlation between the positive rate of CEA and CA72-4 and between that of CA19-9 and CA72-4, and no correlation was identified between the positive rate of CEA and CA19-9, even if a correlation was identified between the serum levels of the biomarkers. The present study suggested that the evidence that the sensitivity of the three biomarkers in combination is greater than that of any of the biomarkers taken in isolation is due to less co-presentation of CEA, CA19-9 and CA72-4 in patients with GC.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

Zhang

Zhao

2015

Molecular and Clinical Oncology

View full text Add to dashboard Cite

show abstract

“…et al, 2006;Ucar et al, 2008;He et al, 2013), 5.6-50% for CA 19-9 (Ychou et al, 2000;Hwang et al,2004;A.M. et al, 2006;Bagaria et al, 2013), 11.1-54.7% for CA 242 (A.M. et al, 2006Zhu et al, 2012;Li et al, 2013;Yu et al, 2013), and 24-41% for CA 50 (Kuusela et al, 1987;Nilsson et al, 1992;Mittal et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

Tian¹,

Yu²,

Kang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…As for possible explanations of the gap of CEA levels between GC tissues and the sera, there have been several reports that the amount of CEA released into the circulation does not depend mainly on the tissue CEA level, but depends on distribution patterns within the cancerous tissues, tumor differentiation and lymphovascular invasion [29][30][31] ducted immunohistochemical analysis and found that the appearance of CEA in the surrounding stroma led to the elevation of blood CEA levels due to the abnormal distribution of CEA on the basolateral plasma membrane of colorectal cancer cells [32]. Although previous studies demonstrated that CEA-producing GC and CA19-9-producing GC have different characteristics in morphology, histopathology and metastatic preference, the prognostic values of serum CEA and CA19-9 are still under debate [5,6,9,14].…”

Section: Discussionmentioning

confidence: 99%

Perioperative Serum Carcinoembryonic Antigen Levels Predict Recurrence and Survival of Patients with Pathological T2-4 Gastric Cancer Treated with Curative Gastrectomy

et al. 2017

View full text Add to dashboard Cite

Background/Aims: Do serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels serve as prognostic indicators in patients with gastric cancer (GC)? This is a question that has long been disputed. The aim of this study was to evaluate the significance of perioperative serum levels of CEA and CA19-9 for predicting the recurrence and long-term survival after patients with pT2-4 GC undergo curative gastrectomy. Methods: This study included 251 patients with radically resected pT2-4 GC without preoperative treatment. Associations between the preoperative and postoperative serum levels of CEA or CA19-9 and postoperative long-term outcomes and recurrence patterns were evaluated. Results: Preoperative CEA >5.0 ng/mL was an independent prognostic factor of overall survival. Elevation of both preoperative CEA and CA19-9 levels showed no synergistic adverse effects on prognosis. Preoperative levels of these markers achieved superior predictive performance compared with the postoperative values. Adverse prognosis is significantly associated with persistent elevation of CEA levels before and after gastrectomy. Elevation of CEA levels, particularly at postoperative measurement, was significantly associated with hematogenous recurrence. Conclusion: Determination of perioperative CEA levels facilitated predictions of recurrence patterns and prognosis among patients with pT2-4 GC who underwent curative gastrectomy.

show abstract

Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer

Cited by 159 publications

References 8 publications

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

Differences and correlation of serum CEA, CA19-9 and CA72-4 in gastric cancer

Combined Detection of CEA, CA 19-9, CA 242 and CA 50 in the Diagnosis and Prognosis of Resectable Gastric Cancer

Perioperative Serum Carcinoembryonic Antigen Levels Predict Recurrence and Survival of Patients with Pathological T2-4 Gastric Cancer Treated with Curative Gastrectomy

Contact Info

Product

Resources

About