Combined use of myeloid-related protein 8/14 and procalcitonin as diagnostic markers for acute allograft rejection in kidney transplantation recipients

Jung, Da-Yeon; Park, Jae Berm; Lee, Eun-Na; Lee, Hyunah; Joh, Jae‐Won; Kwon, Choon Hyuck David; Ki, Chang‐Seok; Lee, Soo-Youn; Kim, Jong Man

doi:10.1016/j.trim.2007.10.004

Cited by 13 publications

(9 citation statements)

References 14 publications

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“…S100A8, also called myeloid-related protein-8, is secreted by activated mononuclear cells [ 24 ]. Higher serum levels of S100A8 had been associated with acute rejection after transplantation, whereas others did not find any relation [ 25 , 26 ]. More importantly, determination of S100A8 transcripts in 28 allograft biopsies showed lower values in patients with acute rejection episodes who had graft loss through chronic allograft nephropathy compared to those with stable graft function.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-8 Transcripts in Mononuclear Cells Determine Impaired Graft Function after Kidney Transplantation

et al. 2015

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ObjectiveInterleukin-8 (IL-8) has been associated with ischemia reperfusion injury after renal allograft transplantation. Impaired allograft function may cause major impact on patient morbidity and health care costs. We investigated whether transcript levels in mononuclear cells including IL-8 on the first postoperative day may be involved in immediate allograft dysfunction as defined by reduced relative change in plasma creatinine at the first postoperative day.MethodsWe performed a single center, prospective-cohort study of 113 patients receiving kidney transplants. Peripheral blood mononuclear cells were harvested within 24 hours after transplantation. Transcripts were measured using quantitative RT-PCR.ResultsTranscript levels of IL-8 and S100A8 were significantly lower in patients with relative change in plasma creatinine less than 10% at the first postoperative day. Receiver-operator characteristic curves showed that IL-8 predicted the relative change in plasma creatinine less than 10% (area under curve (AUC), 0.80; P = 0.0007). Multivariate analyses showed that lower IL-8 transcripts, longer time on dialysis, higher recipient body mass index and deceased donor type were associated with relative change in plasma creatinine at the first postoperative day less than 10%.ConclusionReduced levels of IL-8 transcripts in peripheral mononuclear cells predict immediate graft dysfunction and delayed graft function.

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Section: Discussionmentioning

confidence: 99%

Interleukin-8 Transcripts in Mononuclear Cells Determine Impaired Graft Function after Kidney Transplantation

et al. 2015

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“…Elevated serum MRP8/14 level was found in several chronic inflammatory conditions, including rheumatoid arthritis, allograft rejections, and inflammatory bowel and lung diseases [20-25]. MRP8/14 was not only involved in promoting the inflammatory response in infected lesions but also identified as a potent amplifier of inflammation during autoimmune reaction [10].…”

Section: Discussionmentioning

confidence: 99%

Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

Peng

Jian

et al. 2011

Cardiovasc Diabetol

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BackgroundMyeloid-related protein 8/14 (MRP8/14) is a stable heterodimer formed by two different calcium-binding proteins (MRP8 and MRP14). Studies have identified that MRP8/14 regulates vascular inflammation and serves as a novel marker of acute coronary syndrome. In this study, we evaluated the correlation between serum levels of MRP8/14, hsCRP, endogenous secretory receptor for advanced glycation end-products (esRAGE) and the occurrence of coronary artery disease (CAD), or carotid intima-media thickness (IMT) when CAD was not yet developed in diabetic patients.MethodsSerum levels of MRP8/14, esRAGE and hsCRP were measured in 375 diabetic patients. Then the results of those who had CAD were compared against who had not. Also, we investigated the associations between above-mentioned indicators and IMT of subjects without CAD in both diabetic group and non-diabetic one.ResultsSerum MRP8/14 was significantly higher in CAD than in non-CAD group (9.7 ± 3.6 ug/ml vs. 8.2 ± 3.0 ug/ml, P < 0.001). It was associated with severity of CAD (r = 0.16, P = 0.026). In non-CAD group, MRP8/14 was associated with IMT in patients with (r = 0.30, P < 0.001) or without diabetes (r = 0.26, P = 0.015). The areas under the curves of receiver operating characteristic for CAD were 0.63 (95% CI 0.57-0.68) for MRP8/14, 0.76 (95% CI 0.71-0.81) for hsCRP and 0.62 (95% CI 0.56 -0.67) for esRAGE.ConclusionIn summary, we report that diabetic patients with CAD had elevated plasma MRP8/14 levels which were also positively correlated with the severity of CAD and carotid IMT in patients without clinically overt CAD.

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“…The inflammatory release of PCT can be induced in two main ways: one is due to toxins released by microbes (endotoxin); and another one is through cell-mediated host response mediated by proinflammatory cytokines (e.g., interleukins 1b and 6, tumor necrosis factor-alpha). It should be noted that procalcitonin is also elevated in noninfectious conditions such as trauma, surgery, cardiogenic shock, burns, heat stroke, acute respiratory distress syndrome, infected necrosis after acute pancreatitis, and rejection after transplantation [24–30]. Today, PCT is known as a SMART biomarker for sepsis and infection since it satisfies all the required criteria, that is, (1) it has a high specificity and sensitivity , (2) it is readily measurable , (3) it is affordable and available in many hospitals, (4) it is responsive and reproducible (5) having half-life of 24 hours, it can be measured in a timely fashion [31].…”

Section: Procalcitonin (Pct)mentioning

confidence: 99%

Biomarkers: A Definite Plus in Pneumonia

Summah

2009

Mediators of Inflammation

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During the past few years, biomarkers have emerged as an indispensible tool in the diagnosis of pneumonia. To find an ideal diagnostic biomarker for pneumonia is not an easy task. Not only should it allow an early diagnosis of the condition, but it should also allow differential diagnosis from other noninfectious conditions. Ongoing research is being done in this field so as to put an array of biomarkers at the disposal of doctors to improve the diagnosis of pneumonia when patients present to them with cough or nonspecific symptoms which could easily be misinterpreted as symptoms of other conditions. Procalcitonin and soluble triggering receptor expressed on myeloid cells-1 have emerged as reliable diagnostic markers in pneumonia, and are better when compared to other markers, namely, C-reactive protein, leukocyte count, and proinflammatory cytokines. Many other biomarkers are being studied for their probable use in diagnosing pneumonia but have yet to prove their benefit.

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Combined use of myeloid-related protein 8/14 and procalcitonin as diagnostic markers for acute allograft rejection in kidney transplantation recipients

Cited by 13 publications

References 14 publications

Interleukin-8 Transcripts in Mononuclear Cells Determine Impaired Graft Function after Kidney Transplantation

Interleukin-8 Transcripts in Mononuclear Cells Determine Impaired Graft Function after Kidney Transplantation

Increased serum myeloid-related protein 8/14 level is associated with atherosclerosis in type 2 diabetic patients

Biomarkers: A Definite Plus in Pneumonia

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