Combined use of serum MCP-1/IL-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia

Systemic Evaluation of Vascular Dysfunction by High‐Resolution Sonography in an Nω‐Nitro‐l‐Arginine Methyl Ester Hydrochloride–Induced Mouse Model of Preeclampsia‐Like Symptoms

“…[23][24][25][26][27] Both the PI and RI of the uterine arteries in patients with preeclampsia were significantly higher than those in a control group. 28 In our study, the PIs and RIs of the umbilical and uteroplacental arteries increased significantly in the L-NAME group to inhibit the growth of the fetus. They are noninvasive indicators for evaluating the condition of the fetus.…”

“…Increasing RIs and PIs of the umbilical and uteroplacental arteries mean greater resistance in the placental microcirculation in pregnancies complicated by hypertension and intrauterine growth restriction . Both the PI and RI of the uterine arteries in patients with preeclampsia were significantly higher than those in a control group . In our study, the PIs and RIs of the umbilical and uteroplacental arteries increased significantly in the l ‐NAME group to inhibit the growth of the fetus.…”

Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia

“…In samples obtained in the first trimester, some evidence suggests that IL-10 concentrations are significantly higher in women who developed preeclampsia compared to women with healthy pregnancy [65 58], while others indicate no significant difference [ 42 , 96 ]. In samples collected in the second trimester, IL-10 is significantly lower in women who later develop preeclampsia compared to women who remain healthy [ 58 , 77 , 97 , 98 ]. Furthermore, mean IL-10 concentrations at 14-18 weeks are also significantly lower in women who developed severe preeclampsia (21.54 pg/mL) compared to women with mild preeclampsia (14.84 pg/mL) [ 98 ].…”

“…In samples collected in the second trimester, IL-10 is significantly lower in women who later develop preeclampsia compared to women who remain healthy [ 58 , 77 , 97 , 98 ]. Furthermore, mean IL-10 concentrations at 14-18 weeks are also significantly lower in women who developed severe preeclampsia (21.54 pg/mL) compared to women with mild preeclampsia (14.84 pg/mL) [ 98 ]. Another study, however, reported no difference in IL-10 at 14-18 weeks between women who later developed preeclampsia and women who did not [ 99 ].…”

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

“…Aberrant placental aging and increased placental senescence have been demonstrated in preeclamptic placentas [7]. Several SASP components have been shown to be elevated in women with preeclamptic compared to normotensive pregnancies, including the major SASP components, such as IL-6 [8], IL-8 [9], plasminogen activator inhibitor-1 (PAI-1) [10], and monocyte chemotactic protein-1 (MCP-1) [11]. However, neither the role of MSC, in general, nor their senescence, in particular, has been studied in the context of impaired angiogenesis in preeclampsia.…”