Abstract-In this paper we present a multimethod approach for induction of a specific class of classifiers, which can assist physicians in medical diagnosing in the case of mitral valve prolapse. Mitral valve prolapse is one of the most controversial prevalent cardiac condition and may affect up to ten percent of the population and in the worst case results in sudden death. MultiVeDec is a general framework enabling researchers to generate various intelligent tools based on machine learning. In this paper we focused on various decision tree methods, which are capable of extracting knowledge in a form closer to human perception, a feature that is very important in medical field. The experiment included classifiers with various classical single method approaches, evolutionary approaches, hybrid approaches and also our newest multimethod approach. The main concern of the latest approach is to find a way to enable dynamic combination of methodologies to the somehow quasi unified knowledge representation. The proposed multimethod approach was capable to outperform all other tested approaches by producing classifier for diagnosing mitral valve prolapse with the highest overall and average class accuracy.Keywordsmitral valve prolapse, multimethod approach. intelligent system, decision making, diagnosing, prevalent cardiac conditions, which may affect from five up to ten percent of adult population, and is also one of the most controversial ones, and thereafter hard to diagnose without the use of expensive technology normally not available to general practitioners.With a selection of knowledge representation and concentrating on decision trees we have only narrowed down the potential set of methods. Thereafter in order to find most appropriate classifier from above we tried out different methods for decision tree induction. First we made analysis with widely known tools for decision tree induction C4.5 and CSiSeeS [2]. Despite acceptable results we wanted to find alternative solutions i.e. evolutionary and multimethod approach.