Combining material and structural elasticity – An approach to enhanced compliance of small-calibre vascular grafts

Loewen, Ashlee; Kossel, Klas; Gesché, Valentine; Gries, Thomas; Jockenhoevel, Stefan

doi:10.1088/1757-899x/254/6/062007

Cited by 2 publications

(4 citation statements)

References 4 publications

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“…Endothelialization is also almost complete, which potentially contributes to the reduced proliferation of SMCs. Contrary to the SF graft, the ePTFE remained uncovered to a great extent, even at 24 weeks . Tanaka et al .…”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 97%

“…Contrary to the SF graft, the ePTFE remained uncovered to a great extent, even at 24 weeks. 183 Tanaka et al. 184 prepared an SF vascular graft from a double-raschel knitted mesh with an SF sponge.…”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

“…Most studies using SF to fabricate vascular conduits use braiding, knitting, gel spinning, or electrospinning techniques to enhance the elasticity and the required strength in the final graft. In an investigation done by Filipe et al, 183 they fabricated small-diameter vascular grafts from electrospun SF. They evaluated the mechanical properties compared to a commercial ePTFE graft and native rat aorta.…”

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

“…Contrary to the SF graft, the ePTFE remained uncovered to a great extent, even at 24 weeks. 183 Tanaka et al 184 prepared an SF vascular graft from a double-raschel knitted mesh with an SF sponge. The longitudinal suture retention strength, circumferential tensile strength, and circumferential compressive elastic modulus of the SF grafts were 6.4 ± 0.6 N, 51.0 ± 3.0 N, and 0.013 ± 0.002 N/mm 2 , respectively.…”

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confidence: 99%

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Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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Small-diameter artificial vascular grafts (SDAVG) are used to bypass blood flow in arterial occlusive diseases such as coronary heart or peripheral arterial disease. However, SDAVGs are plagued by restenosis after a short while due to thrombosis and the thickening of the neointimal wall known as intimal hyperplasia (IH). The specific causes of IH have not yet been deduced; however, thrombosis formation due to bioincompatibility as well as a mismatch between the biomechanical properties of the SDAVG and the native artery has been attributed to its initiation. The main challenges that have been faced in fabricating SDAVGs are facilitating rapid re-endothelialization of the luminal surface of the SDAVG and replicating the complex viscoelastic behavior of the arteries. Recent strategies to combat IH formation have been mostly based on imitating the natural structure and function of the native artery (biomimicry). Thus, most recently, developed grafts contain a multilayered structure with a designated function for each layer. This paper reviews the current polymeric, biomimetic SDAVGs in preventing the formation of IH. The materials used in fabrication, challenges, and strategies employed to tackle IH are summarized and discussed, and we focus on the multilayered structure of current SDAVGs. Additionally, the future aspects in this area are pointed out for researchers to consider in their endeavor.

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Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 97%

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

Section: Strategies To Prevent Intimal Hyperplasia In Vascular Graftsmentioning

confidence: 99%

mentioning

confidence: 99%

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Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

2022

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Matching Static and Dynamic Compliance of Small‐Diameter Arteries, with Poly(lactide‐co‐caprolactone) Copolymers: In Vitro and In Vivo Studies

Behr

Irvine

Thwin

et al. 2020

Macromolecular Bioscience

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Mechanical mismatch between vascular grafts and blood vessels is a major cause of smaller diameter vascular graft failure. To minimize this mismatch, several poly‐l‐lactide‐co‐ε‐caprolactone (PLC) copolymers are evaluated as candidate materials to fabricate a small diameter graft. Using these materials, tubular prostheses of 4 mm inner diameter are fabricated by dip‐coating. In vitro static and dynamic compliance tests are conducted, using custom‐built apparatus featuring a closed flow system with water at 37 °C. Grafts of PLC monomer ratio of 50:50 are the most compliant (1.56% ± 0.31∙mm Hg−2), close to that of porcine aortic branch arteries (1.56% ± 0.43∙mm Hg−2), but underwent high continuous dilatation (87 µm min−1). Better matching is achieved by optimizing the thickness of a tubular conduit made from 70:30 PLC grafts. In vivo implantation and function of a PLC 70:30 conduit of 150 µm wall‐thickness (WT) are tested as a rabbit aorta bypass. An implanted 150 µm WT PLC 70:30 prosthesis is observed over 3 h. The recorded angiogram shows continuous blood flow, no aneurysmal dilatation, leaks, or acute thrombosis during the in vivo test, indicating the potential for clinical applications.

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Combining material and structural elasticity – An approach to enhanced compliance of small-calibre vascular grafts

Cited by 2 publications

References 4 publications

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Review of Polymeric Biomimetic Small-Diameter Vascular Grafts to Tackle Intimal Hyperplasia

Matching Static and Dynamic Compliance of Small‐Diameter Arteries, with Poly(lactide‐co‐caprolactone) Copolymers: In Vitro and In Vivo Studies

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