Combining Neural and Behavioral Indicators in the Assessment of Internalizing Psychopathology in Children and Adolescents

Moser, Jason S.; Durbin, C. Emily; Patrick, Christopher J.; Schmidt, Norman B.

doi:10.1080/15374416.2013.865191

Cited by 42 publications

(31 citation statements)

References 94 publications

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“…Additionally, there is evidence that the ERN‐anxiety association may differ between subclinical and clinical levels of anxiety. For instance, while normative levels of anxiety in children have been associated with a blunted ERN (Meyer, Weinberg, et al, ; Moser et al, ; Torpey et al, ), there is also evidence that enhancement of ERN is already evident in children with clinically significant levels of anxiety (Hajcak et al, ; Ladouceur et al, ; Meyer, Hajcak, et al, ). Moreover, we have recently demonstrated that an enhanced ERN at age 6 predicts a new diagnosis of an anxiety disorder at age 9 (Meyer, Proudfit, Torpey‐Newman, et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…For example, there is evidence that the association between an enhanced ERN and subclinical levels of trait anxiety does not emerge until adolescence (Meyer, Weinberg, Klein, & Hajcak, 2012). In younger children, heightened trait anxiety may instead relate to a blunted ERN (Meyer, Weinberg, et al, 2012;Moser, Durbin, Patrick, & Schmidt, 2015). Additionally, a blunted ERN has been observed among young, nonanxious children of mothers with anxiety disorders (Torpey et al, 2013).…”

Section: Ern Development Environment and Risk For Psychopathologymentioning

confidence: 99%

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Error‐related negativity (ERN) and sustained threat: Conceptual framework and empirical evaluation in an adolescent sample

et al. 2016

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The Error-related Negativity (ERN) currently appears as a physiological measure in relation to three RDoC constructs: Cognitive Control, Sustained Threat, and Reward Learning. We propose a conceptual model in which variance in the ERN reflects individual differences in the degree to which errors are evaluated as threatening. We also discuss evidence for the placement of the ERN in the ‘Sustained Threat’ construct, as well as evidence that the ERN may more specifically reflect sensitivity to endogenous threat. Following this, we present data from a sample of 515 adolescent females demonstrating larger ERN in relation to self-reported checking behaviors, but only in older adolescents, suggesting that sensitivity to internal threat and the ERN-checking relationship may follow a developmental course as adolescents develop behavioral control. In contrast, depressive symptoms were linked to smaller ERN, and this association was invariant with respect to age. Collectively, these data suggest that the magnitude of the ERN is sensitive both to specific anxiety-related processes and depression, in opposing directions that may reflect variation in internal threat sensitivity. We discuss directions for future research, as well as ways in which findings for the ERN complement and challenge aspects of the current RDoC matrix.

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Section: Discussionmentioning

confidence: 99%

Section: Ern Development Environment and Risk For Psychopathologymentioning

confidence: 99%

Error‐related negativity (ERN) and sustained threat: Conceptual framework and empirical evaluation in an adolescent sample

et al. 2016

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“…Child behaviors [10] are coded for anxiety and fear during standardized threat tasks, but these constructs are often referred to interchangeably [10]–[12]. While this aggregate fear/anxiety construct has been linked to familial risk for internalizing disorders in young children (e.g., [13]) and parent-reported child fear and internalizing symptoms [14], it does not discriminate the three distinct threat phases. Similarly, the startle phase is commonly measured using the Fear Potentiated Startle (FPS) technique, where electrodes quantify muscle activity during unpleasant stimuli [8], but this technique cannot be used to assess the other phases of threat response.…”

Section: Introductionmentioning

confidence: 99%

Movements Indicate Threat Response Phases in Children at Risk for Anxiety

McGinnis

Muzik

et al. 2017

IEEE J. Biomed. Health Inform.

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Temporal phases of threat response including Potential Threat (Anxiety), Acute Threat (Startle, Fear), and Post-threat Response Modulation have been identified as underlying markers of anxiety disorders. Objective measures of response during these phases may help identify children at risk for anxiety, however the complexity of current assessment techniques prevent their adoption in many research and clinical contexts. We propose an alternative technology, an inertial measurement unit (IMU), that enables non-invasive measurement of the movements associated with threat response, and test its ability to detect threat response phases in young children at heightened risk for developing anxiety. We quantified the motion of 18 children (3–7 years old) during an anxiety/fear provoking behavioural task using an IMU. Specifically, measurements from a single IMU secured to the child’s waist were used to extract root-mean-square acceleration and angular velocity in the horizontal and vertical directions, and tilt and yaw range-of-motion during each threat response phase. IMU measurements detected expected differences in child motion by threat phase. Additionally, potential threat motion was positively correlated to familial anxiety risk, startle range of motion was positively correlated with child internalizing symptoms, and response modulation motion was negatively correlated to familial anxiety risk. Results suggest differential theory-driven threat response phases, and support previous literature connecting maternal child risk to anxiety with behavioural measures using more feasible objective methods. This is the first study demonstrating the utility of an IMU for characterizing the motion of young children to mark the phases of threat response modulation. The technique provides a novel and objective measure of threat response for mental health researchers.

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“…Thus, analyses addressing the structure of the PVS will require multiple measures at each unit of analysis to determine whether there is shared construct variance beyond common method variance. Some preliminary work has found promise for these types of models (Moser, Durbin, Patrick, & Schmidt, 2015; Patrick et al, 2013). However, it is critical that multiple assessments from each unit of analysis be available, such that the unit of analysis is not confounded with the construct of interest.…”

Section: Developmental Extensions Of Pvsmentioning

confidence: 99%

Future Research Directions in the Positive Valence Systems: Measurement, Development, and Implications for Youth Unipolar Depression

Olino

2016

Journal of Clinical Child & Adolescent Psychology

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The Positive Valence Systems (PVS) have been introduced by the National Institute of Mental Health as a domain to help organize multiple constructs focusing on reward seeking behaviors. However, the initial working model for this domain is strongly influenced by adult constructs and measures. Thus, the present review focuses on extending the PVS into a developmental context. Specifically, the review provides some hypotheses about the structure of the PVS, how PVS components may change throughout development, how family history of depression may influence PVS development, and potential means of intervening on PVS function to reduce onsets of depression. Future research needs in each of these areas are highlighted.

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Combining Neural and Behavioral Indicators in the Assessment of Internalizing Psychopathology in Children and Adolescents

Cited by 42 publications

References 94 publications

Error‐related negativity (ERN) and sustained threat: Conceptual framework and empirical evaluation in an adolescent sample

Error‐related negativity (ERN) and sustained threat: Conceptual framework and empirical evaluation in an adolescent sample

Movements Indicate Threat Response Phases in Children at Risk for Anxiety

Future Research Directions in the Positive Valence Systems: Measurement, Development, and Implications for Youth Unipolar Depression

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