Excessive levels of vibration in commercial vehicles, due to excitation from the road irregularities, can lead to cargo damage and safety problems. In order to study the cargo ride safety problem, a three dimension (3D) finite element model of full vehicle was established, which differs from the previous two dimension (2D) one. The computation algorithm for acceleration power spectral density (PSD) and root mean square (RMS) was also given. For the sake of comparisons, two frames with different stiffness were given in the computations of PSD and RMS of body vertical accelerations for four excitation cases. The computed results showed that when the stiffness of the frame increases, the RMS values of the body decreases strongly at the frequency band 14-26Hz, which can effectively improve the cargo ride safety.