In this article, an advanced observer-based finite-time trajectory tracking controller is investigated for lower extremity exoskeleton without available joint angular velocities to improve the movement ability of dependent persons, which is robust against uncertain dynamics, human active joint torque and external disturbances. First, the Lagrange principle is applied to analyze the dynamic properties of lower extremity exoskeleton driven by artificial pneumatic muscles, and its swing phase model is established. After that, a novel finite-time extended state observer is proposed to observe the lumped disturbances and unavailable angular velocities of the lower limb exoskeleton simultaneously. Furthermore, a finite-time sliding mode controller of exoskeleton is designed based on the extended state observer, and the finite-time convergence of tracking error is rigorously demonstrated based on the Lyapunov theory. Finally, the control system simulation is established and experimental tests are conducted with a voluntary subject during flexion of wearer’s knee and hip joints, the obtained results demonstrate fast and high-precision tracking performance of the proposed approach.