Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Nakamoto, Nobuhiro; Amiya, Takeru; Aoki, Ryo; Taniki, Nobuhito; Koda, Yuzo; Miyamoto, Kentaro; Teratani, Toshiaki; Suzuki, Takahiro; Chiba, Sayako; Chu, Po–Sung; Hayashi, Akira; Yamaguchi, Akihiro; Shiba, Shintaro; Miyake, Rei; Katayama, Tadashi; Suda, Wataru; Mikami, Yohei; Kamada, Nobuhiko; Ebinuma, Hirotoshi; Saito, Hidetsugu; Hattori, Masahira; Kanai, Takanori

doi:10.1016/j.celrep.2017.10.022

Cited by 71 publications

(57 citation statements)

References 45 publications

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“…In chickens treated with FMT, a positive correlation was observed between the expression of IL-22 in the ileum and cecal tonsil and the genera Lactobacillus and Clostridium cluster XIVb . In mice, IL-22 deficiency was associated with decreased abundance of genus Lactobacillus , while higher abundance of the genus Lactobacillus was associated with restoration of the epithelial barrier integrity and higher IL-22 production by gut resident innate lymphoid cells in mice 46,47 . Clostridium cluster XIVb are butyrate producing bacteria and accounted for almost 60% of the mucin-adherent microbiota in a previous study 48,49 , and this might be associated with the recovery of the ileal morphology observed in the current study, even though more studies are required to establish this observation.…”

Section: Discussionmentioning

confidence: 96%

Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses

Yitbarek

Taha-Abdelaziz

Hodgins

et al. 2018

Sci Rep

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Commensal gut microbiota plays an important role in health and disease. The current study was designed to assess the role of gut microbiota of chickens in the initiation of antiviral responses against avian influenza virus. Day-old layer chickens received a cocktail of antibiotics for 12 (ABX-D12) or 16 (ABX-D16) days to deplete their gut microbiota, followed by treatment of chickens from ABX-12 with five Lactobacillus species combination (PROB), fecal microbial transplant suspension (FMT) or sham treatment daily for four days. At day 17 of age, chickens were challenged with H9N2 virus. Cloacal virus shedding, and interferon (IFN)-α, IFN-β and interleukin (IL)-22 expression in the trachea, lung, ileum and cecal tonsils was assessed. Higher virus shedding, and compromised type I IFNs and IL-22 expression was observed in ABX-D16 chickens compared to control, while PROB and FMT showed reduced virus shedding and restored IL-22 expression to levels comparable with undepleted chickens. In conclusion, commensal gut microbiota of chickens can modulate innate responses to influenza virus subtype H9N2 infection in chickens, and modulating the composition of the microbiome using probiotics- and/or FMT-based interventions might serve to promote a healthy community that confers protection against influenza virus infection in chickens.

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Section: Discussionmentioning

confidence: 96%

Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses

Yitbarek

Taha-Abdelaziz

Hodgins

et al. 2018

Sci Rep

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“…Lactobacilli, Streptococci , and Escherichia coli are found in small numbers in the gut. However, alteration of the gut microbiota composition can lead to multiple diseases in humans and animals [ 21 , 22 , 28 , 30 ].…”

Section: Modulation Of Gut Microbiota and Probiotic Speciesmentioning

confidence: 99%

Probiotic Species in the Modulation of Gut Microbiota: An Overview

Azad

Sarker

et al. 2018

BioMed Research International

607

400

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Probiotics are microbial strains that are beneficial to health, and their potential has recently led to a significant increase in research interest in their use to modulate the gut microbiota. The animal gut is a complex ecosystem of host cells, microbiota, and available nutrients, and the microbiota prevents several degenerative diseases in humans and animals via immunomodulation. The gut microbiota and its influence on human nutrition, metabolism, physiology, and immunity are addressed, and several probiotic species and strains are discussed to improve the understanding of modulation of gut microbiota. This paper provides a broad review of several Lactobacillus spp., Bifidobacterium spp., and other coliform bacteria as the most promising probiotic species and their role in the prevention of degenerative diseases, such as obesity, diabetes, cancer, cardiovascular diseases, malignancy, liver disease, and inflammatory bowel disease. This review also discusses a recent study of Saccharomyces spp. in which inflammation was prevented by promotion of proinflammatory immune function via the production of short-chain fatty acids. A summary of gut microbiota alteration with future perspectives is also provided.

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“…While the detrimental role of gut dysbiosis seems to be a widely recognized, there is also evidence indicating a beneficial impact of GM on acute liver injury in mice. Enrichment of intestinal Lactobacillus was found in mice with liver injury induced by acute concanavalin A (Con A) treatment, which can prevent further liver inflammation through activation of IL-22 production [38]. Furthermore, conflicting evidence supporting either a detrimental [39,40] or beneficial [14,41] effect of GM can be found for the liver injury in the ATP-binding cassette, sub-family B (MDR/TAP), member 4 (Mdr2) knockout (Mdr2 -/-) mice.…”

Section: Gut Dysbiosis Can Be An Adaptive Response To Liver Injurymentioning

confidence: 99%

Gut dysbiosis protects against liver injury in autophagy deficient mice by FXR-FGF15 feedback signaling

Yan

Khambu

Chen

et al. 2020

Preprint

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Objective:The gut microbiota (GM) can have complicated and often undetermined interactions with the function of many organs in the body. GM is altered in a variety of liver diseases, but the significance of such changes on the liver disease is still unclear. Hepatic autophagy deficiency causes liver injury accompanied with cholestasis. Here, we investigated the impact of such hepatic changes on GM and in turn the effect of gut dysbiosis on liver injury. Design:Fecal microbiota from mice with liver-specific loss of autophagy-related gene 5 (Atg5), Atg5 ∆hep mice, were analyzed by 16S sequencing. Antibiotics (ABX) was used to modulate GM in mice.Cholestyramine was used to reduce the enterohepatic bile acid (BA) level. The functional role of fibroblast growth factor 15 (FGF15) and ileal farnesoid X receptor (FXR) was examined in mice overexpressing FGF15 gene, or given a fibroblast growth factor receptor 4 (FGFR4) inhibitor. Results:The composition of GM was significantly changed with a notable increase of BA-metabolizing bacteria in Atg5 ∆hep mice, leading to a lower proportion of tauro-conjugated BAs and a higher proportion of unconjugated BAs in the intestine, which markedly activated ileal FXR with an increased expression of FGF15. ABX or cholestyramine treatment exacerbated liver injury and ductular reaction, and decreased FGF15 expression, whereas modulating FGF15 signaling altered liver phenotypes in the autophagy-deficient mice. Conclusion:Gut dysbiosis can remedy liver injury in Atg5 ∆hep mice through the FXR-FGF15 signaling.Antibiotics use in the condition of liver injury may have unexpected adverse consequences via the gutliver axis.

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Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Cited by 71 publications

References 45 publications

Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses

Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses

Probiotic Species in the Modulation of Gut Microbiota: An Overview

Gut dysbiosis protects against liver injury in autophagy deficient mice by FXR-FGF15 feedback signaling

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