Probiotic Species in the Modulation of Gut Microbiota: An Overview

Azad, Md. Abul Kalam; Sarker, Manobendro; Li, Tiejun; Yin, Jie

doi:10.1155/2018/9478630

Cited by 605 publications

(458 citation statements)

References 78 publications

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“…Previously we have shown that polyphenol‐rich GSF significantly reduced HF‐induced intestinal permeability and hepatic inflammation. Probiotics such as lactobacillus have known to modulate intestinal permeability . The current study showed a reduction of genes ( Nr1d1, Raet1b, Spon2 ) associated with response to LPS and immune response following GSF and LAB supplementation.…”

Section: Discussionsupporting

confidence: 53%

Combination of Whole Grapeseed Flour and Newly Isolated Kefir Lactic Acid Bacteria Reduces High‐Fat‐Induced Hepatic Steatosis

Kwon

Lee

Seo

et al. 2018

Molecular Nutrition Food Res

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Scope This study aims to determine the separate and combined effect of a prebiotic (catechin‐rich wine grapeseed flour, GSF) and a probiotic (newly isolated kefir lactic acid bacteria, LAB) on hepatic steatosis of obese mice. Methods and results High‐fat (HF)‐induced obese mice are fed a HF diet containing 6% microcrystalline cellulose (MCC, control), 10% GSF, orally administrated LAB, or a combination of GSF and LAB for 9 weeks. There is a significant reduction of body weight gain and liver weights, plasma insulin concentrations, and HOMA‐IR in all experimental groups compared to control. Total lipid content, triglyceride, and low‐density lipoprotein (LDL)‐cholesterol concentrations of the liver are also significantly lowered. The combination of GSF and LAB further significantly affects cecum propionate content, plasma aspartate aminotransferase (AST/GOT), and zonulin concentrations, which is significantly correlated with hepatic lipid content. Analysis of hepatic microarray data reveals that genes related to lipid synthesis, bile acid and cholesterol synthesis, antioxidant activities, oxidative stress, inflammation, and liver function are significantly modulated following the combination of GSF and LAB. Conclusion These data suggest that amelioration of HF‐induced hepatic steatosis after consumption of GSF and LAB is partially mediated via alteration of cecum propionate and intestinal permeability, which modulates hepatic gene expression.

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Section: Discussionsupporting

confidence: 53%

Combination of Whole Grapeseed Flour and Newly Isolated Kefir Lactic Acid Bacteria Reduces High‐Fat‐Induced Hepatic Steatosis

Kwon

Lee

Seo

et al. 2018

Molecular Nutrition Food Res

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“…In addition, a higher abundance of Ruminococcaceae was detected in obese than normal weight mice (Kim et al ). Bifidobacteria has been shown to be involved in nutrient metabolism and energy recycling, which play important roles in the trophic, metabolic and protective functions of the host (Blais et al ; Azad et al ). Our study showed that the abundance of Oscillibacter decreased in the jejunum of IUGR piglets at 21 days of age, as well as Bifidobacterium in the ileum of IUGR piglets at 28 days of age.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances

Zhang

Xie

et al. 2019

J of Applied Microbiology

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Aim Intrauterine growth retardation (IUGR) is a prevalent problem in mammals. The present study was conducted to unveil the alterations in intestinal microbiota in IUGR piglets. Methods and Results We identified the alterations of small intestinal microbiota in IUGR piglets on 7, 21 and 28 days of age using 16S rRNA sequencing. The results showed that IUGR piglets had a decreased alpha diversity of jejunum microbiota at 7 and 21 days of age; had lower abundances of Bacteroidetes and Bacteroides in the jejunum at 7, 21 and 28 days of age, Oscillibacter in the jejunum at 21 days of age, and Firmicutes in the ileum at 21 days of age; whereas they had higher abundances of Proteobacteria and Pasteurella in the ileum at 21 days of age and Escherichia–Shigella in the jejunum at 28 days of age. Correlation analysis showed that Bacteroides, Oscillibacter and Ruminococcaceae_UCG‐002 compositions were positively associated with the body weight (BW) of IUGR piglets, nevertheless Proteobacteria and Escherichia–Shigella relative abundances were negatively correlated with the BW of IUGR piglets. Gene function prediction analysis indicated that microbiota‐associated carbohydrate metabolism, lipid metabolism, glycan biosynthesis and metabolism, amino acid metabolism, and xenobiotics biodegradation and metabolism were downregulated in the IUGR piglets compared to control piglets. Conclusions The present study profiled the intestinal microbiota of newborn piglets with IUGR and the newborn IUGR piglets have lower diversity and different taxonomic abundances. Alterations in the abundances of Bacteroidetes, Bacteroides, Proteobacteria Escherichia–Shigella and Pasteurella may be involved in nutrient digestion and absorption, as well as the potential mechanisms connecting to the growth and development of IUGR in mammals. Significance and Impact of the Study The small intestinal microbiota were highly shaped in the IUGR piglets, which might further mediate the growth and development of IUGR piglets; and the gut microbiota could serve as a potential target for IUGR treatment.

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“…Studies from animals and humans have indicated that there is a marked difference in the gut microbiota between obese and lean subjects, and the microbiota in the obese may further manipulate host metabolism leading to enhanced adiposity, inflammatory response, oxidative stress, and metabolic dysfunction . Xu et al also indicated that melatonin improves the richness and diversity of gut microbiota and reverses 14 operational taxonomic units (OTUs) in HF diet‐fed mice, especially for the ratio of Firmicutes to Bacteroidetes .…”

Section: Introductionmentioning

confidence: 99%

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin

Han

et al. 2018

Journal of Pineal Research

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277

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Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.

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Probiotic Species in the Modulation of Gut Microbiota: An Overview

Cited by 605 publications

References 78 publications

Combination of Whole Grapeseed Flour and Newly Isolated Kefir Lactic Acid Bacteria Reduces High‐Fat‐Induced Hepatic Steatosis

Combination of Whole Grapeseed Flour and Newly Isolated Kefir Lactic Acid Bacteria Reduces High‐Fat‐Induced Hepatic Steatosis

Gut microbiota of newborn piglets with intrauterine growth restriction have lower diversity and different taxonomic abundances

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

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