Comment on “Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis”

Messemaker, Tobias; Toes, René E. M.; Mikkers, Harald; Kurreeman, Fina

doi:10.4049/jimmunol.1500822

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Smac: a Unique Activation Fragment1

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Cited by 2 publications

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“…Based on this stoichiometry, at least fifteen different sMAC complexes are possible. Since each of the protein subunits in sMAC have polymorphic variants (34)(35)(36)(37)(38)(39)(40)(41)(42)(43), there are many sMAC variants at the population level (similar to polymorphism at the population level for MHC molecules). The biological roles of A B FIGURE 1 | Schematic depicting complement activation and soluble membrane attack complex (sMAC) and MAC formation.…”

Section: Smac: a Unique Activation Fragmentmentioning

confidence: 99%

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

2020

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Section: Smac: a Unique Activation Fragmentmentioning

confidence: 99%

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

2020

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A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels

et al. 2015

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Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated in human disease and some have been shown to harbour quantitative trait loci (eQTLs) in autoimmune diseases. However, lncRNAs linked to the transcription of candidate risk genes in loci associated to rheumatoid arthritis (RA) have not yet been identified. The TRAF1 and C5 risk locus shows evidence of multiple eQTLs and transcription of intergenic non-coding sequences. Here, we identified a non-coding transcript (C5T1lncRNA) starting in the 3' untranslated region (UTR) of C5. RA-relevant cell types express C5T1lncRNA and RNA levels are further enhanced by specific immune stimuli. C5T1lncRNA is expressed predominantly in the nucleus and its expression correlates positively with C5 mRNA in various tissues (P=0.001) and in peripheral blood mononuclear cells (P=0.02) indicating transcriptional co-regulation. Knockdown results in a concurrent decrease in C5 mRNA levels but not of other neighbouring genes. Overall, our data show the identification of a novel lncRNA C5T1lncRNA that is fully located in the associated region and influences transcript levels of C5, a gene previously linked to RA pathogenesis.

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Comment on “Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis”

Cited by 2 publications

References 6 publications

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

Soluble Membrane Attack Complex: Biochemistry and Immunobiology

A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels

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