Comment: What Does Left–Right Autonomic Asymmetry Signify?

Critchley, Hugo; Nagai, Yoko

doi:10.1177/1754073914565520

Cited by 3 publications

(3 citation statements)

References 14 publications

(14 reference statements)

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“…The faster SCR may provide additional insights. (6) In the future, EDA should be measured on both hands because the EDA difference between the hands (termed “EDA asymmetry”) is an additional innovative indicator for the state of the ANS 154 – 157 to potentially capture reactivity to the colors. EDA was only measured on one hand, because the other hand was occupied by the pulse oximetry sensor.…”

Section: Discussionmentioning

confidence: 99%

Effect of short-term colored-light exposure on cerebral hemodynamics and oxygenation, and systemic physiological activity

et al. 2017

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There is not yet a comprehensive view of how the color of light affects the cerebral and systemic physiology in humans. The aim was to address this deficit through basic research. Since cerebral and systemic physiological parameters are likely to interact, it was necessary to establish an approach, which we have termed "systemic-physiology-augmented functional near-infrared spectroscopy (SPA-fNIRS) neuroimaging." This multimodal approach measures the systemic and cerebral physiological response to exposure to light of different colors. In 14 healthy subjects (9 men, 5 women, age: [Formula: see text] years, range: 24 to 57 years) exposed to red, green, and blue light (10-min intermittent wide-field visual color stimulation; [Formula: see text] blocks of visual stimulation), brain hemodynamics and oxygenation were measured by fNIRS on the prefrontal cortex (PFC) and visual cortex (VC) simultaneously, in addition with systemic parameters. This study demonstrated that (i) all colors elicited responses in the VC, whereas only blue evoked a response in the PFC; (ii) there was a color-dependent effect on cardiorespiratory activity; (iii) there was significant change in neurosystemic functional connectivity; (iv) cerebral hemodynamic responses in the PFC and changes in the cardiovascular system were gender and age dependent; and (v) electrodermal activity and psychological state showed no stimulus-evoked changes, and there was no dependence on color of light, age, and gender. We showed that short-term light exposure caused color-dependent responses in cerebral hemodynamics/oxygenation as well as cardiorespiratory dynamics. Additionally, we showed that neurosystemic functional connectivity changes even during apparently stress-free tasks-an important consideration when using any of the hemodynamic neuroimaging methods (e.g. functional magnetic resonance imaging, positron emission tomography, and fNIRS). Our findings are important for future basic research and clinical applications as well as being relevant for everyday life.

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Section: Discussionmentioning

confidence: 99%

Effect of short-term colored-light exposure on cerebral hemodynamics and oxygenation, and systemic physiological activity

et al. 2017

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“…The suggested “multiple arousal theory” raised considerable interest and resulted in several commentaries followed by authors’ response (Critchley and Nagai, 2015; Mendes, 2016; Norman, 2016; Picard et al, 2016; Richter, 2016; Sabatinelli, 2016). While these commentaries were in general positive toward the concept of multiple arousal theory, the need for more systematic research including testable and falsifiable predictions has been voiced (Richter, 2016).…”

Section: Introductionmentioning

confidence: 99%

An Investigation on Bilateral Asymmetry in Electrodermal Activity

Bjørhei

Pedersen

Saeed

et al. 2019

Front. Behav. Neurosci.

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The Multiple Arousal Theory ( Picard et al., 2016 ) was proposed to explain retrospective observations of bilateral differences in electrodermal activities occurring in threat-related high-stake situations. The theory proposes different cortical and subcortical structures to be involved in the processing of various facets of emotional states. Systematic investigations of this effect are still scarce. This study tested the prediction of bilateral electrodermal effects in a controlled laboratory environment where electrodermal activity (EDA) was recorded bilaterally during normal activity and two stress-tasks in 25 healthy volunteers. A visual search stress task with a performance-related staircase algorithm was used, ensuring intersubjectively comparable stress levels across individuals. After completion of the task, a sense of ownership of an attractive price was created and loss aversion introduced to create a high-stake situation. Confirmation of the theory should satisfy the hypothesis of a bilateral difference in EDA between the dominant and non-dominant hand, which is larger during high-stake stressors than during low-stake stressors. The bilateral difference was quantified and compared statistically between the two stress-tasks, revealing no significant difference between them nor any significant difference between the stress tasks and the period of normal activity. Subgroup analysis of only the participants with maximum self-rating of their desire to win the price ( n = 7) revealed neither any significant difference between the two tasks nor between the stress-tasks and the period of normal activity. Although the theory was not confirmed by this study, eight cases suggestive of bilateral difference within the recordings were identified and are presented. Because the study is limited in using one of several possible operationalizations of the phenomenon, it is not possible to draw a general conclusion on the theory. Nevertheless, the study might contribute to a better understanding and encourage systematic review and hypothesis development regarding this new theory. Possible explanations and suggestions for future pathways to systematically investigate the Multiple Arousal Theory are discussed.

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“…That said, a measurable change in EDA is not necessary for arousal (see what follows). Critchley and Nagai's (2016) commentary is fascinating, telling of how asymmetric sympathetic arousal from the right side of the brain is associated with cardiac arrhythmia. Our theory can also make predictions in this case: if the sympathetic activation is strongly right-sided to the heart, then all other sources held constant, we would expect to see EDA also be higher on the right wrist than on the left.…”

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confidence: 99%