Commentary: coeliac disease, mortality and malignancy

Ludvigsson, Jonas F.

doi:10.1111/j.1365-2036.2012.05005.x

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Gluten-free Diet For the Prevention Of Complications In Mars1

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“…A recent meta-analysis assessing the risk of allcause mortality, any malignancy and any lymphoid malignancy has found an increased risk of mortality and non-Hodgkin's lymphoma; particularly T-cell non-Hodgkin's lymphoma. By contrast, they did not find an overall elevated risk of any malignancy [40 && , 41,42]. Increased mortality was similarly found in patients with Marsh III, Marsh I-II (named as 'inflammation') and latent coeliac disease [43].…”

Section: Gluten-free Diet For the Prevention Of Complications In Marsmentioning

confidence: 71%

Is a gluten-free diet necessary in Marsh I intestinal lesions in patients with HLADQ2, DQ8 genotype and without gastrointestinal symptoms?

Carrasco

Fernández‐Bañares

2012

Current Opinion in Clinical Nutrition and Metabolic Care

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An appropriate differential diagnosis of the lymphocytic duodenosis is essential before a GFD is indicated. As a third of patients remained undiagnosed, in spite of genetic study and specific coeliac serology, flow cytometry and transglutaminase antibodies in duodenal tissue may be helpful in establishing gluten-sensitive enteropathy diagnosis. Future studies should assess whether lymphoma risk is reduced by a GFD in Marsh I patients. Also a more precise benefit in bone mineralization in this setting is needed.

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Section: Gluten-free Diet For the Prevention Of Complications In Marsmentioning

confidence: 71%