Commentary: Iron deficiency and hair loss

Elston, Dirk M.

doi:10.1016/j.jaad.2009.09.054

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…Hemoglobin yapımı için gerekli olan demirin ilk mobilize olduğu birim kıl follikülleridir. Dolayısıyla kanda anemi görülmeden çok önce saçlarda dökülme görülebilir 8,9 . Serum ferritin düzeyi demir eksikliğini göstermek için en hassas ve özgün laboratuar testidir.…”

Section: Demirunclassified

“…Serum ferritin düzeyi demir eksikliğini göstermek için en hassas ve özgün laboratuar testidir. Yapılan çalışmalarda, ferritin düzeyleri değerlendirilirken 41 ng/ml düzeyinin demir eksikliğini %98 hassasiyetle gösterdiği tespit edilmiştir [8][9][10] . İdeal saç gelişimi için ferritin düzeylerinde standardizasyon gelişmemişse de, yapılan çalışmalar, serum ferritini 40 ng/ml altına düştüğünde telogen fazın arttığını, 40-70 ng/ml ferritin düzeylerinde telogen fazın halen daha uzun olduğu, 70 ng/ml üzerinde kılların normal anagen faza geçtiğini göstermiştir 11 .…”

Section: Demirunclassified

“…Demir eksikliği olan her kişide saç dökülmesi görülmese de, genetik olarak yatkın kişilerde, demir depolarının boşalmasının, saçların dökülmesine neden olduğu kabul edilmektedir. Dolayısıyla saç dökülmelerinde, demir depolarının istenilen düzeylere getirilmesi önerilmektedir 1,4,[8][9][10][11][12][13] .…”

Section: Demirunclassified

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Diffuse alopecia; nutritional factors and supplements

Aksoy¹

2014

TURKDERM

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Hair is constantly produced and shed. The hair follicles producing the hair require calories, proteins, trace elements, and vitamins for this intense biosynthetic activity. Thus, hair growth quality and quantity are closely related to an individuals diet. The nutritional factors that are important for hair growth, and thus should be evaluated, and if deficient replaced in alopecias will be discussed in this review.

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Section: Demirunclassified

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Diffuse alopecia; nutritional factors and supplements

Aksoy¹

2014

TURKDERM

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“…Telogen effluvium is not common in the athletic population, but awareness of the condition may facilitate its early detection and treatment, thereby reducing its severity.  11,12,13 Iron deficiency • Iron involved in critical physiologic processes within the hair follicle • May be the first sign of modest deficiency; only abnormal ferritin levels and no laboratory signs of anemia Zinc deficiency • No direct correlation has been made • Most likely linked to iron deficiency Vitamin D deficiency • Essential in cell growth through the body Caloric restriction • Inadequate protein and essential fatty acid intake • Cause body to cease nonessential functions Medical conditions 11,14 Hypothroidism/hyperthyroidism Chronic systematic disorders Autoimmune disease Physiological stress 6 Occurs because body suspends nonessential functions to devote energy to healing response to surgical trauma, high fever, chronic illness, hemorrhage Emotional stress 6,11 Relationship hard to ascertain, but cases have been reported in extreme emotional disturbances Daily stressors not enough to trigger hair loss…”

Section: Discussionmentioning

confidence: 99%

Hair Loss in a Female Distance Runner

Kramer

Blakey

Statuta

et al. 2014

International Journal of Athletic Therapy and Training

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“…As well as cysteine, iron represents another critical factor involved in many physiological processes of hair follicle, such as growth, maturation, and cell division, suggesting that iron deficiency could affect hair synthesis [Trost et al, ; Elston, ; St Pierre et al, ]. Indeed, several iron metabolism disorders, including the ones characterized by dietary reduced adsorption, are associated to anemia and hair loss, both resolved by iron supplementation therapy [Du et al, ].…”

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confidence: 99%

Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

et al. 2015

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L-cysteine is currently recognized as a conditionally essential sulphur amino acid. Besides contributing to many biological pathways, cysteine is a key component of the keratin protein by its ability to form disulfide bridges that confer strength and rigidity to the protein. In addition to cysteine, iron represents another critical factor in regulating keratins expression in epidermal tissues, as well as in hair follicle growth and maturation. By focusing on human keratinocytes, the aim of this study was to evaluate the effect of cysteine supplementation as nutraceutical on keratin biosynthesis, as well as to get an insight on the interplay of cysteine availability and cellular iron status in regulating keratins expression in vitro. Herein we demonstrate that cysteine promotes a significant up-regulation of keratins expression as a result of de novo protein synthesis, while the lack of iron impairs keratin expression. Interestingly, cysteine supplementation counteracts the adverse effect of iron deficiency on cellular keratin expression. This effect was likely mediated by the up-regulation of transferrin receptor and ferritin, the main cellular proteins involved in iron homeostasis, at last affecting the labile iron pool. In this manner, cysteine may also enhance the metabolic iron availability for DNA synthesis without creating a detrimental condition of iron overload. To the best of our knowledge, this is one of the first study in an in vitro keratinocyte model providing evidence that cysteine and iron cooperate for keratins expression, indicative of their central role in maintaining healthy epithelia.

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Commentary: Iron deficiency and hair loss

Cited by 10 publications

References 43 publications

Diffuse alopecia; nutritional factors and supplements

Diffuse alopecia; nutritional factors and supplements

Hair Loss in a Female Distance Runner

Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

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