Commentary on: a review on delayed toxic effects of sulfur mustard in Iranian veterans

Shadboorestan, Amir

doi:10.1186/2008-2231-20-99

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…With great thanks, we noted the reasonable suggestions presented in the recent commentary [1] about our article on toxicity of mustard [2]. It was commented that the frequency of ophthalmic complications due to sulfur mustard should be 39.3% based on the cited study [3] while it was reported 93.3%.…”

Section: Dear Editor-in-chiefmentioning

confidence: 86%

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Letter to editor; delayed ophthalmotoxic effects of sulfur mustard and clean up the contaminated soils

Razavi

Payman

2013

DARU J Pharm Sci

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Section: Dear Editor-in-chiefmentioning

confidence: 86%

“…Furthermore, in the commentary, concerns regarding the need for decontamination of the soil around the battle fields were come up [1]. We had already mentioned it in our article by terms of "building healthy soil".…”

Section: Dear Editor-in-chiefmentioning

confidence: 99%

Letter to editor; delayed ophthalmotoxic effects of sulfur mustard and clean up the contaminated soils

Razavi

Payman

2013

DARU J Pharm Sci

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Delayed Complications and Long-Term Effects of SM Poisonings: Experience of Iran-Iraq War

Darchini-Maragheh

Blain

Balali‐Mood

2015

Basic and Clinical Toxicology of Mustard Compounds

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Th17/Treg-related cytokine imbalance in sulfur mustard exposed and stable chronic obstructive pulmonary (COPD) patients: correlation with disease activity

Imani

Salimian

et al. 2016

Immunopharmacology and Immunotoxicology

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In this study, we investigated expression changes of Th17/Treg-related cytokine in transbronchial lung biopsy (TBLBs) of sulfur mustard (SM) exposure, stable chronic obstructive pulmonary disease (COPD) patients and also compared it with a healthy control (HC) group. Here, ROR-γt, FoxP3, and Treg/Th17-related cytokines (IL-10, IL-17A, IL-6, and TGF-β1) were assessed using a combination of RT-QPCR and ELISA in 11 SM-exposed cases, 9 patients with GOLD stage II COPD diagnosed, and 8 HC. Our results showed that the levels of Foxp3 expression were lower and ROR-γt expression was higher in SM and COPD patients when compared with HC (all p values were less than 0.001). The relative Foxp3 expressions and Foxp3/ROR-γt ratio were positively correlated with FEV1 (%) pred (R = 0.682 and R = 0.602, respectively; p ≤ 0.001). However, the relative ROR-γt expressions were inversely correlated with FEV1 (%) pred (R= -0.75, p = 0.003) and relative Foxp3 expression (R= -0.704, p = 0.003). The mRNA and protein expression of IL-10 were significantly decreased in SM and COPD patients compared with HC (p < 0.001). An increase of IL-17A (∼7.2 fold) and TGF-β1 (∼5.6 fold) are involved in the lung exacerbation of SM and COPD patients. The expression of IL-6 was variable between three groups (p ≥ 0.05). In addition, an inverse correlation were observed between FEV1 (%) pred and expressions of IL-17A (R= -0.741), IL-6 (R= -0.673) and TGF-β1 (R= -0.632) (p ≤ 0.001). Instead, positive correlation was found between IL-10 ratios and FEV1 (%) pred (R = 0.777, p = 0.001). These findings suggest that Treg/Th17-mediated distributions are involved in the progression of chronic lung injury of SM and COPD patients.

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Commentary on: a review on delayed toxic effects of sulfur mustard in Iranian veterans

Cited by 6 publications

References 11 publications

Letter to editor; delayed ophthalmotoxic effects of sulfur mustard and clean up the contaminated soils

Letter to editor; delayed ophthalmotoxic effects of sulfur mustard and clean up the contaminated soils

Delayed Complications and Long-Term Effects of SM Poisonings: Experience of Iran-Iraq War

Th17/Treg-related cytokine imbalance in sulfur mustard exposed and stable chronic obstructive pulmonary (COPD) patients: correlation with disease activity

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