Commentary on ‘Reduced Subjective Response to Acute Ethanol Administration Among Young Men with a Broad Bipolar Phenotype’

Schuckit, Marc A.

doi:10.1038/npp.2012.61

Cited by 1 publication

(1 citation statement)

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“…We previously demonstrated a reduced subjective psychostimulant response to acute ethanol administration among young men at increased risk for BD (Yip et al, 2012), which-as highlighted by Schuckit (2012)-was strikingly similar to the 'low level response' frequently observed among young adults family history positive for AUDs (eg, Schuckit and Smith, 1996;Schuckit, 2012). This low level of response in completely antipsychotic-naive subjects could reflect neurodevelopmental alterations-eg, in dopaminergic transmission (Bahi and Dreyer, 2012) or in white matter pathway development )-relating to the elevated rates of both substance and nonsubstance addictions observed across BD subtypes (Swann et al, 2005;Merikangas et al, 2007;Di Nicola et al, 2010;Swann, 2010).…”

Section: Introductionmentioning

confidence: 96%

Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder

Yip

Worhunsky

Rogers

et al. 2014

Neuropsychopharmacol

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Increased activity within known reward-processing neurocircuitry (eg, ventral striatum, VS) has been reported among medicated individuals with bipolar disorder (BD) I and II. However, such findings are confounded by the potential ameliorative effects of moodstabilizing and antipsychotic medications on neural activations. This study tests the hypothesis that a pathophysiological locus of alterations in reward processing is present within the striatum in antipsychotic and lithium-naive individuals with BD. Twenty antipsychotic and lithium-naive individuals with BD II or BD not-otherwise specified (NOS) and 20 matched healthy comparison individuals participated in functional magnetic resonance imaging during the performance of a monetary incentive delay task. Between-group comparisons were conducted using small-volume correction focusing on orthogonal a priori regions of interest centered in the VS and dorsal striatum (DS), respectively. During reward anticipation, unmedicated individuals with BD II/NOS had decreased activity within the DS (but not VS). During loss anticipation, on the other hand, decreased activation within both the VS and DS was observed. Across all participants, DS activity (during reward anticipation) was positively associated with putamen volume. This is the first report of decreased dorsal and ventral striatal activity among unmedicated individuals with BD II/NOS. These data contradict a simple 'reward hypersensitivity' model of BD, and add to a growing body of literature suggesting that blunted reward processing may be a vulnerability factor for both mood-and addiction-related disorders.

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