Commentary: Post fever retinitis and vasculitis: A morphological conundrum

Panchal, Bhavik

doi:10.4103/ijo.ijo_1644_18

Cited by 17 publications

(17 citation statements)

References 7 publications

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“…PFR group included individuals with PFR which normally manifested 2 to 4 weeks after systemic infections like Typhoid [ 14 ], Malaria and Chikungunya [ 17 ] caused due to a wide array of infectious agents such as bacteria, parasites and viruses [ 18 , 19 ]. All individuals who presented with features of retinitis (please see introduction) and who had a past history of fever were considered to be having post fever retinitis.…”

Section: Methodsmentioning

confidence: 99%

Mycobiome changes in the vitreous of post fever retinitis patients

et al. 2020

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Fungi have been associated with various diseases of the eye like keratitis, uveitis and endophthalmitis. Despite this fact, fungal microbiome (mycobiome) studies compared to the bacterial microbiome studies have remained neglected. In the present study, using metagenomic sequencing, the mycobiomes of the vitreous of healthy control individuals (VC, n = 15) and individuals with post fever retinitis + non-PFR uveitis (PFR+, n = 9) were analysed and compared. The results indicated that Ascomycota was the most predominant phylum in both VC and PFR+ groups. Further, at the genera level it was observed that the abundance of 17 fungal genera were significantly different in post fever retinitis (PFR, n = 6) group compared to control group. Of these 17 genera, it was observed that 14 genera were relatively more abundant in PFR group and the remaining 3 genera in the VC group. Genus Saccharomyces, a commensal of the gut and skin, was predominantly present in the vitreous of both the cohorts, however it was significantly less abundant in PFR group. Further, significant increase in the genera that have a pathogenic interaction with the host were observed in PFR group. On the whole the mycobiome in both the groups differed significantly and formed two distinct clusters in the heatmap and Principal co-ordinate analysis. These results demonstrate significant changes in the mycobiome from the vitreous of post fever retinitis patients compared to healthy controls thus implying that dysbiotic changes in the fungal vitreous microbiome are associated with PFR.

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Section: Methodsmentioning

confidence: 99%

Mycobiome changes in the vitreous of post fever retinitis patients

et al. 2020

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“…[5][6][7] This usually occurs between 2 and 4 weeks after the fever in immunocompetent patients, irrespective of etiology caused by either bacteria, viruses, or protozoa. 8 Available literature shows that the presentation of this condition several days to weeks after a systemic illness has an immunological basis. 7,8 Mild cases may resolve spontaneously without treatment but severe cases may require corticosteroids and other immunosuppressive agents.…”

Section: Discussionmentioning

confidence: 99%

“…8 Available literature shows that the presentation of this condition several days to weeks after a systemic illness has an immunological basis. 7,8 Mild cases may resolve spontaneously without treatment but severe cases may require corticosteroids and other immunosuppressive agents. 9 Our patient presented with bilateral retinal capillaritis with background of Klebsiella liver abscess which resolved spontaneously post treatment of the abscess with systemic antibiotics and drainage.…”

Section: Discussionmentioning

confidence: 99%

A rare association of retinal capillaritis with Klebsiella liver abscess

Rasheed

Pillai²,

Pareshbhai³

et al. 2021

IJCEO

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A 32-year-old male, diagnosed with liver abscess presented with sudden painless decreased vision in both eyes. Ophthalmological examination showed retinal capillaritis with cystoid macular edema. Pus from the liver abscess yielded Klebsiella pneumoniae. After drainage of liver abscess and systemic antibiotics, patient’s vision improved in both eyes with complete resolution of the macular edema. This is a rare case of retinal capillaritis associated with Klebsiella liver abscess.

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“…1,2 It is a relatively newer entity, described in literature by various names like epidemic retinitis, post febrile retinitis, acute multifocal retinitis and post febrile uveitis. 1,2,3 Patients with PFR typically develop unilateral or bilateral retinitis after 2-4 weeks of febrile illness. 4 It is characterized by the presence of unifocal or multifocal retinitis, predominantly involving the posterior pole and peripapillary region.…”

Section: Introductionmentioning

confidence: 99%

Predictors of visual outcome in post-fever retinitis: a retrospective analysis

Biswal¹,

Gondchawar²,

Ravishankar³

et al. 2021

Int Ophthalmol

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Purpose: To identify the predictors of nal visual outcome in cases with post fever retinitis (PFR). Methods : This is a retrospective study of cases with diagnosis of post fever retinitis. Color fundus photograph and optical coherence tomography (OCT) parameters at presentation and nal visit were analysed. Various factors at presentation [age, systemic illness, best corrected visual acuity (BCVA), area of retinitis and hard exudates, OCT parameters], at nal visit (optic disc pallor, OCT parameters) and the treatment modalities used were correlated with BCVA at nal visit.

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Commentary: Post fever retinitis and vasculitis: A morphological conundrum

Cited by 17 publications

References 7 publications

Mycobiome changes in the vitreous of post fever retinitis patients

Mycobiome changes in the vitreous of post fever retinitis patients

A rare association of retinal capillaritis with Klebsiella liver abscess

Predictors of visual outcome in post-fever retinitis: a retrospective analysis

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