Comments on Immunopathology

Fj, Dixon

doi:10.1093/milmed/131.suppl_9.1233

Cited by 24 publications

(4 citation statements)

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“…It has, however, been shown by fluorescent-antibody techniques that in this condition there are heavy deposits of hosts' gamma and beta IC globulins along the capillary basement membranes (Dixon, 1966). This phenomenon has also been noted in simian malaria (Ward and Conran, 1966).…”

Section: Necropsy Findingsmentioning

confidence: 92%

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Pathology of malaria in West Africa.

Edington¹

1967

BMJ

110

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Section: Necropsy Findingsmentioning

confidence: 92%

“…Dixon (1966) has suggested that the erythrocyte is affected by circulating malarial antigen-antibody complexes, which may be absorbed on to the red cell. With complement fixation, opsonization and phagocytosis-or even outright lysis-may occur.…”

Section: Malarial Anaemiamentioning

confidence: 99%

Pathology of malaria in West Africa.

Edington¹

1967

BMJ

110

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“…Although, infections with non- falciparum species generally result in mild disease [ 1 , 2 ], their identification is important. In fact, P. malariae is known not to cause severe symptoms, but is sometimes associated with renal pathology [ 3 - 6 ]. Evidence suggests that P. malariae does not cause relapse, but low level parasitaemia can persist for years and recrudescent infections are well documented [ 7 ] and can cause disease years after the initial infection [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury associated with Plasmodium malariae infection

Badiane

Diongue

Diallo

et al. 2014

Malar J

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According to current estimates, Plasmodium malariae is not very common in Senegal, as more than 98% of malaria cases are suspected to be due to Plasmodium falciparum. However, it is possible that other malarial species are being under-reported or misdiagnosed. This is a report of a case of P. malariae in a 30-year-old man previously hospitalized with acute kidney injury after treatment with quinine and re-hospitalized three months later. He was diagnosed with renal cortical necrosis post malaria treatment. Plasmodium malariae was identified with light microscope and confirmed using species-specific small-subunit rRNA (ssrRNA) amplification.The patient was treated for malaria with intravenous quinine for seven days, followed by three days of oral treatment; the bacterial infection was treated using ceftriaxone during the first hospitalization and ciprofloxacin associated with ceftriaxone the second time. He also had four rounds of dialysis after which he partially recovered the renal function. Given the complications that can be caused by P. malariae infection, it should be systematically looked for, even if the predominant species is P. falciparum in Senegal.

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“…The early work of Dixon [3], in which he considered that the deposition of malaria antigen-antibody complexes along the basement mem brane of glomerular capillaries might lead to subsequent renal damage and activation of complement, has been carried further to show that IgG, IgM and fiiC component were pre sent as granular deposits along the glomerular blood vessels. Why P.malariae should be in criminated in these lesions and not the much more common P.falciparum remains in triguing.…”

Section: Renal Biopsymentioning

confidence: 99%

Nephrology in the Tropical Setting

Oo¹

1978

Nephron

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The pattern of renal disease and its basic principles of management are essentially the same in the tropics as in the temperate environment. Glomerulonephritis and pyelonephritis with concomitant hypertension account for most cases of renal failure. Malaria is now well recognised as a cause of the nephrotic syndrome. Economic and manpower factors dictate a conservative approach to therapy. Maintenance haemodialysis and renal transplantation are not realistic in the present context, having regard to the order of priorities in health care delivery.

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Comments on Immunopathology

Cited by 24 publications

References 0 publications

Pathology of malaria in West Africa.

Pathology of malaria in West Africa.

Acute kidney injury associated with Plasmodium malariae infection

Nephrology in the Tropical Setting

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