Commitment and differentiation of lung cell lineages

Warburton, David; Wuenschell, Carol; Flores‐Delgado, Guillermo; Anderson, Kathryn D.

doi:10.1139/bcb-76-6-971

Cited by 39 publications

(29 citation statements)

References 222 publications

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“…When these findings are compared with previous reports of pulmonary carcinosarcoma, neuroendocrine cell differentiation in the carcinoma component of the present case 2 and case 3 is rather unique [3,6,11,16]. However, no carcinoma cells in the present study revealed the expression of airway epithelial cell differentiation-specific transcription factors, TTF-1, GATA6, HNF3 alpha, and HNF3 beta, nor any surfactant proteins (SPA, SPB, and SPC) [18,19,20]. Pulmonary neuroendocrine cells are among the first cells to differentiate in the primitive lung epithelium [19].…”

Section: Discussionsupporting

confidence: 72%

“…In normal lung development, mesenchymal signals induce a specific lung epithelial phenotype [18,19]. Of high possible interest in this immunohistochemical study was the fact that many of the carcinoma cells in case 3 and some carcinoma cells in case 2, both of which formed a rhabdomyosarcomatous component in the tumor tissue, revealed strong positive staining for the neuroendocrine cell markers of chromogranin and synaptophysin.…”

Section: Discussionmentioning

confidence: 96%

“…Recently in molecular embryology of the lung or other tissues and organs, great progress has been made in significant molecular determinants of the growth and development process [9,18,19]. In normal lung epithelial development, through the possible interaction with their mesenchymal components, TTF-1, GATA-6, Gli-1, HNF-3 alpha, and HNF-3 beta were assumed to play the key roles and regulate the expression of surfactant proteins and some lineage-specific marker proteins for airway epithelial cell differentiation [18,19].…”

Section: Introductionmentioning

confidence: 99%

“…In normal lung epithelial development, through the possible interaction with their mesenchymal components, TTF-1, GATA-6, Gli-1, HNF-3 alpha, and HNF-3 beta were assumed to play the key roles and regulate the expression of surfactant proteins and some lineage-specific marker proteins for airway epithelial cell differentiation [18,19]. The expression of these factors in lung diseases and tumors, however, remains to be clarified, although it has begun to be reported in some lung epithelial tumor pathology [21].…”

Section: Introductionmentioning

confidence: 99%

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Electron microscopy and immunohistochemistry studies of pulmonary carcinosarcomas expressing the transcription factor MEF-2 and showing significant cell-to-cell, cell-to-matrix, and epithelial?mesenchymal interactions

Yamazaki

2004

Virchows Arch

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Pulmonary carcinosarcomas are typified by the rare histological combination of mixed epithelial and mesenchymal malignant tumor cells. The author has experienced three cases of pulmonary carcinosarcomas with large mass formation. Case 1 was the combination of adenocarcinoma with focal squamous cell differentiation and chondrosarcoma. In case 2, adenocarcinoma was combined with rhabdomyosarcoma. Case 3 demonstrated a large cell neuroendocrine carcinoma and rhabdomyosarcoma. The immunohistochemical findings showed that many of the carcinoma cells in case 3 and some carcinoma cells in case 2 demonstrated neuroendocrine cell differentiation. The nuclei in all sarcoma cells stained definitively positive for the transcription factor MEF-2. Many of the lineage-specific transcription factors for lung development were not distributed in the tumor tissue. Ultrastructurally, in all three cases, cell-to-cell (forming cellular junctions), cell-to-matrix, and epithelial-mesenchymal interactions were seen. In the interface or boundary between the carcinoma cell nests and the matrix-embedded sarcoma cells, well-developed basal lamina and fibroblastic spindle cells were frequently seen, with an appearance similar to primitive fibroblastic or mesenchymal cells, extending thin cytoplasmic process around the carcinoma cell nests. In summary, carcinosarcoma cells interacted with each other and with their extracellular matrix, revealed MEF-2 in the sarcoma cells, and showed unique histological findings associated with a variety of phenotypic differentiation patterns very different from normal lung development.

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electron microscopy and immunohistochemistry studies of pulmonary carcinosarcomas expressing the transcription factor MEF-2 and showing significant cell-to-cell, cell-to-matrix, and epithelial?mesenchymal interactions

Yamazaki

2004

Virchows Arch

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“…congenital airway obstructions) [28,29]. Primitive endodermal cells differentiate into several lineages of which the most studied are the types 1 and 2 pneumocyte and which may also include pulmonary stem cells [30,31]. Pulmonary epithelium is responsible for lung liquid production (via chloride-secretion): this results in prenatal lung having a small positive intraluminal pressure relative to the thoracic cavity [32].…”

Section: An Overview Of Lung Development Reveals Points Of Clinical Imentioning

confidence: 99%

Exploiting mechanical stimuli to rescue growth of the hypoplastic lung

Jesudason

2007

Pediatr Surg Int

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Impaired lung development afflicts a range of newborns cared for by paediatric surgeons. As a result the speciality has led in the development of surgical models that illustrate the biomechanical regulation of lung growth. Using transgenic mutants, biologists have similarly discovered much about the biochemical regulation of prenatal lung growth. Airway smooth muscle (ASM) and its prenatal contractility airway peristalsis (AP) represent a novel link between these areas: ASM progenitors produce an essential biochemical factor for lung morphogenesis, whilst calcium-driven biomechanical ASM activity appears to regulate the same. In this invited paper, I take the opportunity both to review our recent findings on lung growth and prenatal ASM, and also to discuss mechanisms by which ASM contractility can regulate growth. Finally, I will introduce some novel ideas for exploration: ASM contractility could help to schedule parturition (pulmonary parturition clock) and could even be a generic model for smooth muscle regulation of morphogenesis in similar organs.

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Protein phosphatase 1α is required for murine lung growth and morphogenesis

Hormi-Carver¹,

Shi²,

Liu³

et al. 2004

Developmental Dynamics

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Protein phosphatase 1 (PP1) plays important roles in cell cycle control and apoptosis, two processes that impinge on morphogenesis and differentiation. Following the precedent set by other molecules regulating the cell cycle and apoptosis, we hypothesized that PP1 may have context-specific roles in development. Therefore, we have studied the spatial and temporal expression of PP1␣ during murine lung development and determined the consequences of loss of PP1␣ function on branching morphogenesis. By using an immunohistochemical approach, we show here that PP1␣ was expressed throughout the epithelium and mesenchyme upon the emergence of the lung primordium on embryonic day 10, with immunostaining exclusively extranuclear. During the late pseudoglandular stage, PP1␣ was predominantly expressed in the distal lung epithelium, whereas the mesenchyme contained very little or no PP1␣ protein. Peri-and postnatally, PP1␣ immunostaining was mostly nuclear in apparently differentiated cells, as judged by colocalization with well-known markers for lung differentiation. Exposure of fetal lung explants to antisense oligodeoxynucleotides against PP1␣, resulted in decreased overall size of the cultured lung, a defect in forming new airways, lack of expression of surfactant protein C, and histologic signs of poor differentiation. These data suggest that PP1␣ is required for branching morphogenesis and differentiation. Developmental Dynamics 229:791-801, 2004.

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Commitment and differentiation of lung cell lineages

Cited by 39 publications

References 222 publications

Electron microscopy and immunohistochemistry studies of pulmonary carcinosarcomas expressing the transcription factor MEF-2 and showing significant cell-to-cell, cell-to-matrix, and epithelial?mesenchymal interactions

Electron microscopy and immunohistochemistry studies of pulmonary carcinosarcomas expressing the transcription factor MEF-2 and showing significant cell-to-cell, cell-to-matrix, and epithelial?mesenchymal interactions

Exploiting mechanical stimuli to rescue growth of the hypoplastic lung

Protein phosphatase 1α is required for murine lung growth and morphogenesis

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