Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon

Abstract

This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3 -rs4994 and ABCC8 -rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11 -rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants.

Study of Genetic Drifts in Some Fat Mass and Obesity Associated Gene Variatiants in Type 2 Diabetics in Some Ethinic Groups Residing in Delta State, Nigeria

“…similar finding exists among Brazilian population [17]. changes from expected frequency could be due to cross-breeding that may have occurred in previous generations [18], considering the multi-ethnic nature of the geographical population of the study area this might apply to the genetic drift observed for the studied FTO variants.…”

“…The FTO gene exists in different genetic forms known as variants of FTO polymorphisms. FTO gene rs9939609 SNP is significantly associated with obesity, With the AA genotype carriers having a 2.02 increased risk of developing obesity [5]. interdependece exist between biochemical parameters of T2D with FTO gene, namely insulin, glucose, HOMA, BMI, waist and hips circumference [6].…”

Avaliação da obesidade na população indígena da Região Norte: Uma revisão integrativa

“…A desnutrição infantil é especialmente alarmante, com altas taxas de anemia por falta de ferro e atraso no crescimento e ganho de peso, frequentemente superando as médias regionais e nacionais. Ao mesmo tempo, a obesidade entre os adultos começa a se tornar um desafio sério em algumas comunidades indígenas (Leite et al, 2007;Capelli & Koifman, 2001;Vieira-Filho et al, 2004;Costa, 2007;Rodrigues et al, 2023;Diniz et al, 2022).…”

“…Entretanto, os perfis antropométricos apontam para condições Research, Society andDevelopment, v. 12, n. 7, e10012742557, 2023 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v12i7.42557 mais desfavoráveis durante os meses chuvosos, período em que as taxas de desnutrição em crianças aumentam e os adultos de ambos os sexos apresentam médias de peso corporal mais baixas (Leite et al, 2007). De maneira geral, Diniz et al (2022) verificou que a prevalência de excesso de peso em populações indígenas da Amazônia brasileira estudados foi menor do que a relatada para adultos urbanos brasileiros, assim como a prevalência de obesidade e obesidade central, com exceção dos Gavião Kyikatêjê e Asurini do Xingu, nos quais foram identificadas altas taxas de obesidade e obesidade abdominal. Esses resultados podem ser atribuídos às intensas mudanças culturais e ambientais que esses grupos têm vivenciado.…”

Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity

“…The misssense variant of rs4994 has been well studied and was first described as being associated with obesity in the Japanese population [60]. More recent studies have shown an association of this variant with obesity and T2DM in populations of East Asia [59], Iran [58], and the indigenous population of the Amazon [61]. The mechanism by which this variant acts is thought to be an alteration in receptor function leading to the decreased expression of hormone-sensitive lipase (HSL), most likely causing obesity [62].…”