Common clinical manifestations of serotonin deficiency and intoxication syndrome

Simonenkov, A. P.; Fedorov, V D

doi:10.1007/bf02458067

Cited by 1 publication

(4 citation statements)

References 7 publications

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“…Apart from hemoglobin and myoglobin, other partial serotonin agonists are present in the circulation. Serotonin antagonists induce SM relaxation, while partial serotonin agonists interact with SR in SM and induce pathological contraction that differs by the amplitude and duration from the serotonin-induced contraction [13][14][15][16][17][18].…”

Section: Bulletin Of Experimental Biology and Medicine No~ 2 1999 Gmentioning

confidence: 99%

“…when other elements of the "hypoxic chain" were eliminated. This reduced the lethality more than 2-fold in comparison with control groups [14][15][16][17][18].…”

Section: Bulletin Of Experimental Biology and Medicine No~ 2 1999 Gmentioning

confidence: 99%

“…Based on our findings that free (not bound to haptoglobin or other proteins) hemoglobin and myoglobin induce spasm of smooth muscles (SM) and accelerate platelet disintegration and our description of endogenous vasemotion (EVM) and serotonin insufficiency syndrome, we propose a new approach to the genesis and classification of hypoxic states [14][15][16][17][18].…”

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confidence: 99%

“…Serotonin antagonists also impaired SM/unction, despite the presence of oxygen, calcium, potassium, and glucose in the medium, while the addition of serolonin (serotonin adipinate, SA) restored automatism and contractile activity (peristalsis) of SM. This suggests that the agents inhibiting serotonin --serotonin receptors (SR) interaction in SM disturb the spatial and temporal coupling of physicochemical processes underlying translormation of biochemical energy into mechanical one, whereas addition of SA restores lhe disturbed physiological processes [14][15][16][17][18].…”

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confidence: 99%

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Arguments for revision of classification of hypoxic states

Simonenkov

1999

Bull Exp Biol Med

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Hypoxia always leads to dysfunction of organs and culminates in the fatal outcome. The principles of classification of the hypoxic states were formulated in 1930-s. The first successful cardiac transplantation posed the problem of dividing of circulatory cardiovascular hypoxia into two subdivisions: hypoxia associated with impaired cardiac contractility (cardiac insufficiency) and hypoxia resulting from vascular smooth muscle cell. Here we attempted to improve classification of hypoxic states on the basis of new medical achievements. The proposed classification considers the following hypoxic states: 1) exogenous hypoxia; 2) respiratory hypoxia; 3) hypoxia resulting from cardiac insufficiency; 4) hypoxia provoked by vascular smooth muscle dysfunction; 5) hemic hypoxia; 6) tissue hypoxia; and 7) combined hypoxia. There are specific and pathogenically substantiated methods for correction of all elements of the "hypoxic chain" that regulate tissue metabolism at the cellular and subcellular level both in the whole organism and in individual organs. These methods open new vistas in biology and medicine, in particular, in transplantology.

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Section: Bulletin Of Experimental Biology and Medicine No~ 2 1999 Gmentioning

confidence: 99%

“…when other elements of the "hypoxic chain" were eliminated. This reduced the lethality more than 2-fold in comparison with control groups [14][15][16][17][18].…”

Section: Bulletin Of Experimental Biology and Medicine No~ 2 1999 Gmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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