No abstract

Clinical manifestations of serotonin deficiency, its genesis, diagnostics, and treatment are described. The contribution of free hemoglobin and myoglobin to the genesis of absolute serotonin deficiency --disseminated intravascular coagulation (DIC) syndrome --is shown. Evidence is presented suggesting that chronic serotonin deficiency underlies aged-related and diabetic angiopathies. It is demonstrated that the serotonin deficiency syndrome has common clinical manifestations with the intoxication syndrome.

The mobility of neutrophils is found to be depressed by serotonin antagonists (toxins and drugs) in patients with wound infection. Addition of serotonin eliminates serotonin insufficiency of neutrophils, which is expressed in acceleration of their mobility. Data are presented showing that serotonin is indispensable for maintaining neutrophil and platelet homeostasis.