Common Genetic Aspects Between Polycystic Ovary Syndrome and Diabetes Mellitus

Mendoza, Nicolás

doi:10.2174/157339911797579142

Cited by 10 publications

(4 citation statements)

References 101 publications

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“…Earlier studies have identified a higher prevalence of a positive family history of diabetes in PCOS compared with population controls (16)(17)(18). However, later genetic studies have failed to find an association between genes known to influence the heritability of DM2 and the presence of PCOS (19)(20)(21). Together these latter studies imply that the development of DM2 with and without a prior history of PCOS is under different genetic control.…”

Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome in type 2 diabetes: does it predict a more severe phenotype?

Sim

Chin

Tan

et al. 2016

Fertility and Sterility

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A history of PCOS in women with DM2 is associated with earlier onset of DM2, higher BMI, and a more severe phenotype. Since PCOS subjects were less likely to have a family history of DM2, lack of a family history of DM2 in women with PCOS is not reassuring for DM2 risk. We recommend identifying PCOS in early life and intervening to reduce the risk of diabetes and its comorbidities and suboptimal reproductive outcomes.

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Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome in type 2 diabetes: does it predict a more severe phenotype?

Sim

Chin

Tan

et al. 2016

Fertility and Sterility

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“…Genetic alterations in the regulatory region of CYP11A1 and CYP17A1 genes are associated with the pathogenesis of PCOS. Common polymorphisms of CYP17A1 and CYP11A1 genes are hypothesized to predict the individual's susceptibility to PCOS 18 . Similar studies were performed previously in such seven SNPs within CYP11A1 (rs12917295, rs11632698, rs1484215, rs6495096, rs4887139, rs9806234, and rs4886595) in PCOS patients that were genotyped.…”

Section: Discussionmentioning

confidence: 99%

The association of CYP11A1 gene polymorphisms with the polycystic ovary syndrome patients

Alyousif,

Ozbakir,

Ozay

et al. 2024

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The objective of this study was to investigate the allele frequencies of polymorphisms in genes CYP11A1 rs4886595 and CYP11A1 rs4887139 that are responsible for the steroidogenesis mechanism in polycystic ovary syndrome patients and control females. METHODS: Samples were obtained from the Department of Obstetrics and Gynecology in the Near East University Hospital from September 2019 to December 2019. Only the nonobese patients between the ages of 18–40 years were included in this study following informed consent. Obese patients and patients more than 40 years of age were excluded from the study. Nonobese women and normal ovulation were included in the control group. DNA was isolated from blood samples. Real-time polymerase chain reaction (PCR) was used to analyze single nucleotide polymorphisms (SNPs) in various genes linked to polycystic ovary syndrome. The studies were carried out using the samples obtained from 120 women, of whom 55 were nonobese and had normal ovulation, and 65 were polycystic ovary syndrome patients. The allelic frequencies of SNPs in genes linked to polycystic ovary syndrome were calculated using real-time PCR outcomes. RESULTS: The variation of the CYP11A1 rs4887139 G>A did not show any significance, while the variation of CYP11A1 rs4886595 C>A showed significant differences between the patient and the control groups (p=0.01), respectively. CONCLUSION: Future research ought to focus on elucidating the susceptible causes of polycystic ovary syndrome with a wide range of SNPs and more sample size. The genome-wide association studies in polycystic ovary syndrome patients of different origin will be important to identify candidate genes as well as proteins that are implied in polycystic ovary syndrome risk.

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“…3 It has been proven that both obesity and diabetes have a negative impact on fertility, indicating the importance of the prevention and treatment of clinical manifestations of PCOS. 4 The clinical manifestation of PCOS can be heterogeneous, and in cases of anovulatory cycles, the morphological changes most characteristic of PCOS are the accumulation of large antral follicles attributed to a failure in the selection of the dominant follicle and an arrest of development of follicles. 5,6 The hormonal changes and anovulatory cycles in women with PCOS can trigger hyperplasia of the uterine endometrium, which not only affects the process of implantation, but also increases the risk of endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

“…2 PCOS presents itself most commonly as a combination of 20 anovulatory and ovulatory cycles, infertility and hyperandrogenicity and is associated with certain metabolic alterations like obesity, dyslipidemia, insulin resistance and type-2 diabetes, all of which increase the risk of cardiovascular disease. 3 It has been proven that both obesity and 4 The clinical manifestation of PCOS can be heterogeneous, and in cases of anovulatory cycles, the morphological changes most characteristic of PCOS are the accumulation of large antral follicles attributed to a failure in the selection of the dominant follicle and an arrest of development of follicles. 5,6 The hormonal changes and anovulatory cycles in women with PCOS can trigger hyperplasia of the uterine endometrium, which not only affects the process of implantation, but also increases endometrial 30 cancer risk.…”

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confidence: 99%

Subcellular Redistribution of NHERF1 in Response to Dehydroepiandrosterone (DHEA) Administration in Endometrial Glands of Wistar Rats

Kreimann

Cabrini

2013

Reprod. Sci.

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To understand the regulation of Na(+)/H(+) exchanger regulatory factor (NHERF1) in polycystic ovarian syndrome, we studied the expression of NHERF1 in uterus of Wistar rats injected with (6 mg/kg) of dehydroepiandrosterone (DHEA) for 7 and 20 days. Immunohistochemistry analysis of NHERF1 showed a substantial shift in the intracellular localization of NHERF1 in endometrial glands and areas of luminal epithelium as early as 7 days of DHEA administration. The NHERF1 accumulated in the "Golgi apparatus area" virtually in all the glands in the 7-day protocol, and in the majority of the glands of 20-day protocol. In contrast, NHERF1 is expressed in the apical membrane and slightly in the cytoplasm of the control epithelium. The subcellular redistribution of NHERF1 could affect the sorting of proteins to the apical membrane and the organization of the apical compartment.

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Common Genetic Aspects Between Polycystic Ovary Syndrome and Diabetes Mellitus

Abstract: The list of genes candidates involved in PCOS is related to diabetes and inflammatory processes.

Cited by 10 publications

References 101 publications

Polycystic ovary syndrome in type 2 diabetes: does it predict a more severe phenotype?

Polycystic ovary syndrome in type 2 diabetes: does it predict a more severe phenotype?

The association of CYP11A1 gene polymorphisms with the polycystic ovary syndrome patients

Subcellular Redistribution of NHERF1 in Response to Dehydroepiandrosterone (DHEA) Administration in Endometrial Glands of Wistar Rats

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