ObjectivesThis review aimed to synthesise evidence on (1) the prevalence of common mental health disorders (MHDs) in Cameroon; (2) the effectiveness of mental health management interventions; (3) the risk factors for common MHDs in Cameroon and (4) map the state of research on common mental disorders in Cameroon.DesignA systematic review.Data sourcesWe performed a comprehensive search for articles in major public health databases including PubMed, Scopus, Medline, CINAHL, PsycINFO, Web of Science, Embase, CINAHL from inception of each database to June 2022.Eligibility criteriaPublished articles on the prevalence, risk factors or intervention for management of common MHDs in Cameroon met the inclusion criteria for this systematic review.Data extraction and synthesisThe abstract and full-text screening, and data extraction were performed independently by at least two researchers. The results have been reported based on a narrative synthesis.ResultsAfter the screening stages, 32 articles met the inclusion criteria and were included in this study. A high prevalence of common MHDs among different groups, including teenage mothers, students and people living with HIV, was observed. We identified important risk factors for these conditions in the general population and among high-risk groups. We also identified two interventions which show promising results for the management of depression among individuals with HIV in Cameroon.ConclusionOur review recorded a high prevalence of common MHDs and identified important risk factors for MHDs among different groups. Increased priority and participatory action with all stakeholders including individuals, communities/policy holders and in research where a huge gap remains to be filled, is crucial in reducing the burden of MHDs in Cameroon.PROSPERO registration numberCRD42022348427.