Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Kuessel, Lorenz; Grimm, Christoph; Knöfler, Martin; Haslinger, Peter; Leipold, Heinz; Heinze, Georg; Egarter, Christian; Schmid, Maximilian

doi:10.1155/2013/798914

Cited by 15 publications

(16 citation statements)

References 27 publications

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“…To-date many SNPs (several dozen) have been reported in the OXTR gene, however, less is known about their association with physiological processes. Recently some studies have reported association of OXTR gene polymorphisms with PTB risk [ 32 – 34 ]. An exhaustive study was done in 651 PTB infants and their parents for analyses of 16 single nucleotide polymorphisms (SNPs) in genes for OXT and OXTR , and leucyl/cystinyl aminopeptidase ( LNPEP ) [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

“…Two common SNPs of OXTR (rs4686302, rs237902) were shown apparently to be associated with PTB. Kuessel et al [ 34 ] studied four common OXTR polymorphisms (rs53576, rs2254298, rs237911, rs2228485) in 100 women each with PTB and term birth. Although no relationship was revealed for each of the four individual polymorphisms and PTB, however, the haplotype combination of rs2228485 C allele, rs2254298 A allele, and rs237911 G allele was found to be significantly associated with an increased risk of PTB.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

et al. 2016

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BackgroundPreterm birth (PTB), birth at <37 weeks of gestation, is a significant global public health problem. World-wide, about 15 million babies are born preterm each year resulting in more than a million deaths of children. Preterm neonates are more prone to problems and need intensive care hospitalization. Health issues may persist through early adulthood and even be carried on to the next generation. Majority (70 %) of PTBs are spontaneous with about a half without any apparent cause and the other half associated with a number of risk factors. Genetic factors are one of the significant risks for PTB. The focus of this review is on single nucleotide gene polymorphisms (SNPs) that are reported to be associated with PTB.ResultsA comprehensive evaluation of studies on SNPs known to confer potential risk of PTB was done by performing a targeted PubMed search for the years 2007–2015 and systematically reviewing all relevant studies. Evaluation of 92 studies identified 119 candidate genes with SNPs that had potential association with PTB. The genes were associated with functions of a wide spectrum of tissue and cell types such as endocrine, tissue remodeling, vascular, metabolic, and immune and inflammatory systems.ConclusionsA number of potential functional candidate gene variants have been reported that predispose women for PTB. Understanding the complex genomic landscape of PTB needs high-throughput genome sequencing methods such as whole-exome sequencing and whole-genome sequencing approaches that will significantly enhance the understanding of PTB. Identification of high risk women, avoidance of possible risk factors, and provision of personalized health care are important to manage PTB.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3089-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

et al. 2016

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“…We found that in the cell model of oxidative stress, the expression level of OXTR was signi cantly increased compared with the normal cell group, which was consistent with the previous research results and proved that this gene was one of the critical reasons for the development of RSA. OXTR, an important in ammatory factor, plays a vital role in initiating and maintaining delivery (57,58). Myometrium and decidua from pregnant women who underwent cesarean section or hysterectomy during pregnancy (59), and the results showed that OXTR level was low in early pregnancy, whereas in pregnant women with at least 37-week gestational age or premature labor, OXTR level and the sensitivity to oxytocin were signi cantly higher.…”

Section: Discussionmentioning

confidence: 99%

Identification of the Active Constituents and Significant Pathways of Bushen Huoxue Decoction for the Treatment of Recurrent Spontaneous Abortion Based on Network Pharmacology

Wu²,

Kang

et al. 2020

Preprint

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Background: To explore Bushen Huoxue Decoction (BHD) mechanism in recurrent spontaneous abortion (RSA).Methods: We predicted and screened the action targets of four Traditional Chinese Medicine representatives by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and searched the disease targets of RSA through Drugbank, DisGeNET, and TTD databases. According to the obtained drug targets and disease targets, the "drug target-disease target" interaction network was further analyzed and constructed. The core target of BHD for treating RSA was were imported to establish in STRING. GO and KEGG pathway analysis were conducted with the RStudio (ggplot2). Finally, HTR-8/SVneo cells were selected to establish a cell model of oxidative stress, and the network pharmacologic results of BHD-RSA were verified by cell biology, Western blot and qRT-PCR.Results: A total of 73 active compounds were obtained from 1084 ingredients present in the BHD, and 125 genes were closely related to RSA. According to the "drug target-disease target" interaction network analysis, 26 core targets of BHD for treating RSA were finally selected, and 203 biological processes, 10 molecular functions, and 10 cell components were enriched by GO function enrichment. KEGG pathway enrichment related pathways, a total of 19, are mainly associated with a Neuroactive ligand-receptor interaction pathway. Experimental results show that compared with the oxidative stress cell model of RSA, BHD increases the expression of PTGFR, AGTR1 and OXTR mRNA by upregulating the expression of PTGFR, AGTR1 and OXTR protein, which may interfere with the occurrence and development of RSA through Neuroactive ligand-receptor interaction pathway.Conclusion: Combined with the pathological mechanism of RSA and the absence of specific signaling pathways, we hypothesized that the BHD might play a role in tonifying the kidney, strengthening the bone, promoting blood circulation, and removing blood stasis，it also can virtually relieve the symptoms of RSA, and our network pharmacological analysis lays the foundation for future clinical research.These results may help define the possible roles the BHD plays in RSA through Neuroactive ligand-receptor interaction pathway.

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“…Четыре общих полиморфизма гена рецептора окситоцина (rs2254298, rs53576, rs2228485 и rs237911) были оценены у 100 женщин с преждевременными родами и 100 здоровых женщин, родивших своевременно. Было определено, что аллель rs2228485 c и аллель rs237911 G связаны с повышенным риском преждевременных родов (oR = 3,2, 95 % cI 1,04-9,8, p = 0,043) [56].…”

Section: генетические маркеры преждевременных родовunclassified

Challenges and prospects of preterm birth prediction in multiple pregnancies

et al. 2018

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For today, twins make up about 1.5% of the population of our planet. It is more than one hundred million people, which in number corresponds to the population of two Frances. The number of twins born relative to the total number of newborns in different countries and on different continents is different, but the overall trend is that it continues to grow. In recent years, the percentage of multiple pregnancy has increased almost 2.5 times, which is associated with the widespread use of assisted reproductive technologies.At the same time, pregnancy in multiple births is an extremely important problem in modern obstetrics, as it is accompanied by a high level of complications for both the mother and the fetuses. Multiple pregnancy contributes significantly to the formation of adverse perinatal outcomes, which is primarily due to the high rate of preterm birth. Premature twins are at high risk of neurological and neuropsychiatric disorders, respiratory distress, endocrine and metabolic disorders, which subsequently become the cause of disability and social maladaptation of children. In this regard, the reduction in the number of premature births is today a priority task, the solution of which is possible only through timely and correct forecasting. The multifactority of pathogenic mechanisms determines the necessity of diagnostic search strategies that can identify markers of various pathogenetic ways of preterm birth. (For citation: Kosyakova OV, Bespalova ОN. Challenges and prospects of preterm birth prediction in multiple pregnancies. Journal of Obstetrics and Women’s Diseases. 2018;67(4):48-59. doi: 10.17816/JOWD67448-59).

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Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Cited by 15 publications

References 27 publications

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

Spontaneous preterm birth and single nucleotide gene polymorphisms: a recent update

Identification of the Active Constituents and Significant Pathways of Bushen Huoxue Decoction for the Treatment of Recurrent Spontaneous Abortion Based on Network Pharmacology

Challenges and prospects of preterm birth prediction in multiple pregnancies

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