Common polymorphism in the cannabinoid receptor gene type 2 (CB2R) rs3123554 are associated with metabolic changes after two different hypocaloric diets with different dietary fatty profiles

Aller, R.; Primo, David; Izaola, Olatz; Luis, Daniel Antonio de

doi:10.1016/j.clnu.2018.11.013

Cited by 2 publications

(2 citation statements)

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“…Cannabinoid receptor type 2 (CB2R) is the peripheral cannabinoid receptor that regulates the inflammatory response. It is a common genetic variant (G>A; rs3123554) of the CB2R gene, and studies have found that carriers of the A allele have less pronounced improvement in weight, fat mass, and biochemical parameters, such as lipid profile, than non-carriers of the A allele after a hypocaloric diet [ 147 ]. Two studies have been carried out exploring the effect of this variant after weight loss secondary to hypocaloric diets.…”

Section: Molecular Nutritionmentioning

confidence: 99%

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

et al. 2022

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Approximately 25–50% of the population worldwide exhibits serum triglycerides (TG) (≥150 mg/dL) which are associated with an increased level of highly atherogenic remnant-like particles, non-alcoholic fatty liver disease, and pancreatitis risk. High serum TG levels could be related to cardiovascular disease, which is the most prevalent cause of mortality in Western countries. The etiology of hypertriglyceridemia (HTG) is multifactorial and can be classified as primary and secondary causes. Among the primary causes are genetic disorders. On the other hand, secondary causes of HTG comprise lifestyle factors, medical conditions, and drugs. Among lifestyle changes, adequate diets and nutrition are the initial steps to treat and prevent serum lipid alterations. Dietary intervention for HTG is recommended in order to modify the amount of macronutrients. Macronutrient distribution changes such as fat or protein, low-carbohydrate diets, and caloric restriction seem to be effective strategies in reducing TG levels. Particularly, the Mediterranean diet is the dietary pattern with the most consistent evidence for efficacy in HTG while the use of omega-3 supplements consumption is the dietary component with the highest number of randomized clinical trials (RCT) carried out with effective results on reducing TG. The aim of this review was to provide a better comprehension between human nutrition and lipid metabolism.

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Section: Molecular Nutritionmentioning

confidence: 99%

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

et al. 2022

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“…A set of five studies in Caucasian Spanish individuals with obesity (~150 to ~1,000 participants in each) investigated association of SNP rs3123554 with various clinical measures (Aller et al, 2019; de Luis et al, 2017; de Luis et al, 2018; de Luis et al, 2019; Primo et al, 2020). This SNP is ~0.6 kb downstream of the CNR2 coding region, in the intergenic region upstream of FUCA1 , and is in LD with CNR2 exon 3 (Ketterer et al, 2014; Zhang et al, 2015).…”

Section: Cb2 Snp Associations With Diseases and Phenotypesmentioning

confidence: 99%

Single nucleotide polymorphisms in the cannabinoid CB₂ receptor: Molecular pharmacology and disease associations

Foyzun,

Whiting,

Velasco

et al. 2024

British J Pharmacology

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Preclinical evidence implicating cannabinoid receptor 2 (CB2) in various diseases has led researchers to question whether CB2 genetics influence aetiology or progression. Associations between conditions and genetic loci are often studied via single nucleotide polymorphism (SNP) prevalence in case versus control populations. In the CNR2 coding exon, ~36 SNPs have high overall population prevalence (minor allele frequencies [MAF] ~37%), including non‐synonymous SNP (ns‐SNP) rs2501432 encoding CB2 63Q/R. Interspersed are ~27 lower frequency SNPs, four being ns‐SNPs. CNR2 introns also harbour numerous SNPs. This review summarises CB2 ns‐SNP molecular pharmacology and evaluates evidence from ~70 studies investigating CB2 genetic variants with proposed linkage to disease. Although CNR2 genetic variation has been associated with a wide variety of conditions, including osteoporosis, immune‐related disorders, and mental illnesses, further work is required to robustly validate CNR2 disease links and clarify specific mechanisms linking CNR2 genetic variation to disease pathophysiology and potential drug responses.

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Common polymorphism in the cannabinoid receptor gene type 2 (CB2R) rs3123554 are associated with metabolic changes after two different hypocaloric diets with different dietary fatty profiles

Cited by 2 publications

References 30 publications

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

Single nucleotide polymorphisms in the cannabinoid CB₂ receptor: Molecular pharmacology and disease associations

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Common polymorphism in the cannabinoid receptor gene type 2 (CB2R) rs3123554 are associated with metabolic changes after two different hypocaloric diets with different dietary fatty profiles

Cited by 2 publications

References 30 publications

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence

Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations

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Single nucleotide polymorphisms in the cannabinoid CB₂ receptor: Molecular pharmacology and disease associations