Common pregnancy complications and polyphenols intake: an overview

Deckmann, Iohanna; Santos-Terra, Júlio; Martel, Fátima; Carletti, Jaqueline Vieira

doi:10.1080/10408398.2022.2160960

Cited by 3 publications

(2 citation statements)

References 249 publications

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“…In such conditions, polyphenol consumption reduces inflammatory cytokine secretion and oxidative stress and improves signaling pathways regulating mitochondrial physiology, ultimately preventing offspring developmental defects and malformations (Chen et al, 2019; Tropea et al, 2020). However, despite the increasing amount of studies suggesting the effectiveness of polyphenols as a therapeutic option, the limited data about the safety of different polyphenol formulations and timing of consumption during pregnancy still hinder their advancement in clinical trials, particularly after clinical observations have demonstrated cardiovascular defects due to high maternal polyphenol intake (Deckmann et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Late pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT

Gindri dos Santos,

Maciel August,

Santos Rocha

et al. 2024

Intl J of Devlp Neuroscience

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Dietary polyphenol consumption is associated with a wide range of neuroprotective effects by improving mitochondrial function and signaling. Consequently, the use of polyphenol supplementation has been investigated as an approach to prevent neurodevelopmental diseases during gestation; however, the data obtained are still very inconclusive, mostly because of the difficulty of choosing the correct doses and period of administration to properly prevent neurodegenerative diseases without undermining normal brain development. Thus, we aimed to evaluate the effect of naringin supplementation during the third week of gestation on mitochondrial health and signaling in the cerebellum of 21‐day‐old offspring. The offspring born to naringin‐supplemented dams displayed higher mitochondrial mass, membrane potential, and superoxide content in the cerebellum without protein oxidative damage. Such alterations were associated with dynamin‐related protein 1 (DRP1) and phosphorylated AKT (p‐AKT) downregulation, whereas the sirtuin 3 (SIRT3) levels were strongly upregulated. Our findings suggest that high dietary polyphenol supplementation during gestation may reduce mitochondrial fission and affect mitochondrial dynamics even 3 weeks after delivery via SIRT3 and p‐AKT. Although the offspring born to naringin dams did not present neurobehavioral defects, the mitochondrial alterations elicited by naringin may potentially interfere during neurodevelopment and need to be further investigated.

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Section: Introductionmentioning

confidence: 99%

Late pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT

Gindri dos Santos,

Maciel August,

Santos Rocha

et al. 2024

Intl J of Devlp Neuroscience

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“…Major phenolic compounds found within MD, such as hydroxytyrosol, oleuropein (OLE) and resveratrol, have shown benefits in atherosclerosis and polycystic ovary syndrome, by inhibiting the expression of cytokines, chemokines and adhesion molecules induced by inflammatory stimuli [ 15 , 16 , 17 ]. Thus, the use of antioxidants such as the bioactive polyphenol OLE could be a possible approach in the prevention of inflammation- and oxidative stress-related pregnancy disorders as well [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

Pirković,

Jovanović Krivokuća,

Vilotić

et al. 2023

IJMS

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Successful pregnancy establishment requires highly synchronized cross talk between the invasive trophoblast cells and the receptive maternal endometrium. Any disturbances in this tightly regulated process may lead to pregnancy complications. Local factors such as nutrients, hormones, cytokines and reactive oxygen species modulate the invasion of extravillous trophoblasts through critical signaling cascades. Epidemiological studies strongly indicate that a Mediterranean diet can significantly impact molecular pathways during placentation. Therefore, the aim of the current study was to examine whether oleuropein (OLE), one of the main compounds of the Mediterranean diet, may influence trophoblast cell adhesion and migration, as well as the expression of invasion-associated molecular markers and inflammatory pathways fostering these processes. HTR-8/SVneo cells were incubated with OLE at selected concentrations of 10 and 100 µM for 24 h. Results showed that OLE did not affect trophoblast cell viability, proliferation and adhesion after 24 h in in vitro treatment. The mRNA expression of integrin subunits α1, α5 and β1, as well as matrix-degrading enzymes MMP-2 and -9, was significantly increased after treatment with 10 µM OLE. Furthermore, OLE at a concentration of 10 µM significantly increased the protein expression of integrin subunits α1 and β1. Also, OLE inhibited the activation of JNK and reduced the protein expression of COX-2. Finally, a lower concentration of OLE 10 µM significantly stimulated migration of HTR-8/SVneo cells. In conclusion, the obtained results demonstrate the effects of OLE on the function of trophoblast cells by promoting cell migration and stimulating the expression of invasion markers. As suggested from results, these effects may be mediated via inhibition of the JNK signaling pathway.

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The effect of maternal dietary polyphenol consumption on offspring metabolism

Zhou,

Ren,

et al. 2024

Critical Reviews in Food Science and Nutrition

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Common pregnancy complications and polyphenols intake: an overview

Cited by 3 publications

References 249 publications

Late pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT

Late pregnancy maternal naringin supplementation affects the mitochondria in the cerebellum of Wistar rat offspring via sirtuin 3 and AKT

Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

The effect of maternal dietary polyphenol consumption on offspring metabolism

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