Introduction: Visual impairment caused severe disability in 2.2 billion people globally in 2010. This disability, which interacts with the physical, social, or attitudinal environment, spans across the lifecycle, and is associated with psychological distress and poor quality of life. This study aimed at describing the effect of surgery on blindness, QoL, anxiety and depressive disorders.Methods A one arm pre – post study was conducted among systematically-selected visually impaired adults (> 18 years) requiring surgery at the National Eye Centre (NEC), Nigeria. Trained research assistants used a pre-tested semi-structured questionnaire to interview participants at pre – and 10–12 week’s post-surgery. The visual function was measured with presenting visual acuity. Presence of psychological distress was defined by a scores ≥ 8 on the Hospital Anxiety and Depression scale (HADs), and confirmed the presence of anxiety, and depression using Mini International Neuropsychiatric Interview (MINI) questionnaire. The World Health Organization Quality of Life-Bref questionnaire was used to assess the quality of life. Descriptive analysis for frequency and proportions was carried out while Chi square McNemar test used to detect the effect of surgery on blindness, anxiety, depression and QoL. Statistically significant was set at p Value < 0.05.Results Of the 180 respondents, males accounted for 56.7%, and 72.2% had Cataract. Pre-surgical psychological distress, anxiety and depression were 38.9%, 25.6%, and 30.0%, respectively. Pre-surgery, a third had poor QoL on social relationship domain of WHOQoL-Bref. Ophthalmic surgery significantly improved blindness, anxiety, and social relationship QoL. No significant effect on depression.Conclusions Ophthalmic surgery influences social relationships QoL, and anxiety. It however has no effect on depression. Apart from surgical interventions, holistic care of vision impairment should involve mental care to improve QoL.