Common variants of FTO and the risk of obesity and type 2 diabetes in Indians

Chauhan, Ganesh; Tabassum, Rubina; Mahajan, Anubha; Dwivedi, Om Prakash; Mahendran, Yuvaraj; Kaur, Ishwinder; Nigam, Shubhanchi; Dubey, Himanshu; Varma, Binuja; Madhu, Sri Venkata; Mathur, Sandeep Kumar; Ghosh, Saurabh; Tandon, Nikhil; Bharadwaj, Dwaipayan

doi:10.1038/jhg.2011.87

Cited by 67 publications

(53 citation statements)

References 33 publications

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“…Two studies in North Indians and Asian Indians demonstrated a strong association of FTO rs9939609 with T2DM independent of BMI [4, 26]. However, contradictory results for association of FTO variants with T2DM have been reported in different ethnic groups of India [27]. Furthermore, a meta-analysis study conducted in South Asia showed that BMI and central obesity can partly account for the association of A allele of the FTO gene and diabetes, whereas this association was much reduced when adjusted for BMI in Europeans indicating ethnic-specific associations [28].…”

Section: Discussionmentioning

confidence: 99%

Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine

et al. 2018

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BackgroundGenetic and environmental factors play a crucial role in the development of type 2 diabetes mellitus (T2DM) and obesity. This study aimed to investigate the association of the fat-mass and obesity-associated gene (FTO) rs9939609 variant with T2DM and body mass index (BMI) among Palestinian population.MethodsA total of 399 subjects were recruited, of whom 281 were type 2 diabetic patients and 118 normoglycemic subjects. All of them were unrelated, aged > 40 years and recruited within the period 2016–2017. The A allele of FTO rs9939609 was identified by PCR–RFLP.ResultsSignificant association of the minor allele A of FTO rs9939609 and T2DM risk was observed with an allelic odd ratio of 1.92 (95% CI [1.09–3.29], p = 0.02) adjusted for age and gender, this association partly attenuated when adjusted for BMI with OR of 1.84, (95%CI [1.04–3.05], p = 0.03). Stratified data by glycemic status across FTO genotypes showed that A allele was marginally associated with increased BMI among diabetic group (p = 0.057) but not in control group (p = 0.7). Moreover, no significant association was observed between FTO genotypes and covariates of age, gender, T2DM complications or any tested metabolic trait in both diabetic and nondiabetic individuals (p > 0.05).ConclusionsThe variant rs9939609 of the FTO gene was associated with T2DM in Palestine. This is the first study conducted on this gene in the Palestinian population and provides valuable information for comparison with other ethnic groups. Further analysis with larger sample size is required to elucidate the role of this variant on the predisposition to increased BMI in Palestinians.

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Section: Discussionmentioning

confidence: 99%

Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine

et al. 2018

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“…In South Asians, several polymorphisms have been discovered that are associated with risk factors that predispose to diabetes – including insulin resistance, 43–46 pancreatic β-cell function, 47–54 adiposity, 44,47,49,50,55–64 and the metabolic syndrome. 65–68 There are several polymorphisms in South Asians that are associated with type 2 diabetes.…”

Section: Factors That Predispose South Asians To Diabetesmentioning

confidence: 99%

Diabetes and Associated Complications in the South Asian Population

2014

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The increasing prevalence of diabetes in South Asians has significant health and economic implications. South Asians are predisposed to the development of diabetes due to biologic and lifestyle factors. Furthermore, they experience significant morbidity and mortality from complications of diabetes, most notably coronary artery disease, cerebrovascular disease and chronic kidney disease. Therefore, understanding the pathophysiology and genetics of diabetes risk factors and its associated complications in South Asians is paramount to curbing the diabetes epidemic. With this understanding, the appropriate screening, preventative and therapeutic strategies can be implemented and further developed. In this review, we discuss in detail the biologic and lifestyle factors that predispose South Asians to diabetes and review the epidemiology and pathophysiology of microvascular and macrovascular complications of diabetes in South Asians. We also review the ongoing and completed diabetes prevention and management studies in South Asians.

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“…For example, the fat mass and obesity associated (FTO) gene is associated with T2D in both Europeans and South Asians; however, the association is entirely mediated by BMI in Europeans but not in Asians [69][70]. Moreover, there are unique genes associated with T2D in Indians [39][40][41]68].…”

Section: Greater Insulin Resistancementioning

confidence: 92%

“…Asian Indian genotype Though some T2D genes are common to Asian Indians and European populations [68][69][70], factors that mediate genetic effects (allele frequencies or polymorphisms) may differ between Asian Indians and Europeans. For example, the fat mass and obesity associated (FTO) gene is associated with T2D in both Europeans and South Asians; however, the association is entirely mediated by BMI in Europeans but not in Asians [69][70].…”

Section: Greater Insulin Resistancementioning

confidence: 99%