Commonly available hematological biomarkers are associated with the extent of coronary calcifications

Harder, Annemarie M. den; Jong, Pim A. de; Groot, Mark de; Wolterink, Jelmer M.; Budde, Ricardo P.J.; Išgum, Ivana; Solinge, Wouter W. van; Berg, Maarten J. ten; Lutgens, Esther; Veldhuis, Wouter B.; Haitjema, Saskia; Hoefer, Imo E.; Leiner, Tim

doi:10.1016/j.atherosclerosis.2018.06.017

Cited by 10 publications

(15 citation statements)

References 38 publications

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“…There is a relationship between the inflammation level and the hemogram parameters such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), red cell distribution width (RDW), and mean platelet volume (MPV), therefore; recently, researchers focused on investigating the reliability of these inexpensive hematological parameters. Many studies have reported that the parameters may be a reliable and inexpensive marker as a prognostic factor for predisposition to thrombosis, cancer patients, cerebrovascular and cardiovascular diseases (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Monocyte to Lymphocyte Ratio, Neutrophil to Lymphocyte Ratio, and Red Cell Distribution Width are the Associates with Gouty Arthritis

Kadıyoran

Zengin

Çizmecioğlu

et al. 2019

Acta Med. (Hradec Kralove, Czech Repub.)

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Background: Neutrophils, monocytes, and macrophages activations are associated with a gout attack. Monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red cell distribution width (RDW), and mean platelet volume (MPV) are well-known inflammation markers. In this study, we aimed to investigate whether they could be a predictive marker to the gout attack. Material and Methods: A hundred and ten gout patients (male/female, 86/24) and 90 (male/female, 64/26) age-, gender-, and body mass index-matched volunteer controls were included in the study. Blood samples were obtained in the intercritical and attack period of the patients. Hemogram, serum uric acid (SUA), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) values were studied. Results: In the attack period NLR (p < 0.001), PLR (p < 0.05), MLR (p < 0.001), RDW (p < 0.05), MPV (p < 0.05), ESR (p < 0.001), CRP (p < 0.001) and SUA (p < 0.001) values were significantly higher than intercritical period values. According to the results of regression analysis; There was an independent strong relationship between the gout attack and SUA, (Beta [β] = 0.352, p < 0.001), ESR (β = 0.329, p < 0.001), CRP (β = 0.286, p < 0.001), MLR (β = 0.126, p < 0.001), RDW (β = 0.100, p = 0.003) and NLR (β = 0.082, p = 0.014). Conclusions: MLR, RDW, and NLR may be a strong predictive marker for a gout attack. MPV and PLR values in the gout attack may be associated with systemic inflammation.

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Section: Introductionmentioning

confidence: 99%

Monocyte to Lymphocyte Ratio, Neutrophil to Lymphocyte Ratio, and Red Cell Distribution Width are the Associates with Gouty Arthritis

Kadıyoran

Zengin

Çizmecioğlu

et al. 2019

Acta Med. (Hradec Kralove, Czech Repub.)

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“…In these patients, even a modest 1% increase in RDW levels increases the risk for all-cause mortality by 47% [ 39 ]. In pre-dialysis CKD, the data remain limited and are mainly derived from three retrospective studies [ 16 , 17 , 18 , 40 ]. In agreement with our results, we have previously showed in a cohort of 142 diabetic CKD patients in various CKD stages that RDW was an independent predictor of CV disease and mortality [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease

et al. 2023

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We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovascular disease (CVD) in chronic kidney disease (CKD). Dephosphorylated, uncarboxylated matrix Gla-protein (dp-ucMGP), and central/peripheral hemodynamics’ parameters were measured in 158 CKD patients, including Hemodialysis and Peritoneal Dialysis. Spearman’s rho analysis showed that RDW correlated with C-reactive protein (CRP) (r = 0.29, p < 0.001), dp-ucMGP (r = 0.43, p = < 0.0001), central diastolic blood pressure (DBP) (r = −0.19, p = 0.02), and albuminuria (r = −0.17, p = 0.03). NLR correlated with the duration of CVD (r = 0.32, p < 0.001), CRP (r = 0.27, p = 0.01), dp-ucMGP (r = 0.43, p < 0.0001), central DBP (r = −0.32, p < 0.0001) and eGFR (r = −0.25, p = 0.04). In multiple regression models, circulating dp-ucMGP was an independent predictor of RDW (β = 0.001, p = 0.001) and NLR (β = 0.002, p = 0.002). In CKD patients, RDW and NLR are associated with traditional and novel markers of VC and CVD.

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“…Several recent studies revealed a relationship between elevated RDW and the burden of coronary atherosclerosis, where elevated RDW was related to a higher coronary artery calcification score [ 32 ]. Another study demonstrated a positive correlation between RDW and the coronary artery calcification score after adjustment for age, sex, BMI, diabetes mellitus, glomerular filtration rate, and high-density lipoprotein cholesterol level [ 33 ]. Oleksiak et al [ 34 ] found that an elevated RDW and coronary calcium score both independently increased the coronary atherosclerotic burden in patients diagnosed with coronary artery disease.…”

Section: Discussionmentioning

confidence: 99%

The combined clinical impact of red blood cell distribution width and vascular calcification on cardiovascular events and mortality in patients with endstage kidney disease

Kim

Lee

et al. 2022

Kidney Res Clin Pract

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Background: Little is known about how the interaction between red blood cell distribution width (RDW) and vascular calcification (VC) affects cardiovascular (CV) events and mortality in end-stage kidney disease (ESKD) patients. This study investigated the combined prognostic effect of RDW and VC in ESKD patients starting dialysis. Methods: A retrospective single-center study of 582 ESKD patients was conducted. VC was assessed by calculating the aortic calcification index (ACI) using computed tomography. Patients were divided into low ACI-low RDW, low ACI-high RDW, high ACI-low RDW, and high ACI-high RDW groups based on median ACI (17.12) and RDW ( 14.3) values. The association between RDW and VC and the composite endpoint of CV events and death was analyzed. Results: During a median follow-up of 3.1 years (range, 1.5-5.5 years), 165 CV events (28.4%) and 124 deaths (21.4%) occurred. Cox regression showed that the low ACI-high RDW (adjusted hazard ratio [HR], 1.66; 95% confidence interval [CI], 1.04-2.66; p = 0.03) and high ACI-low RDW (adjusted HR, 1.95; 95% CI, 1.21-3.14; p = 0.006) groups had a greater risk of CV events and death than the low ACI-low RDW group. The high ACI-high RDW group had the greatest risk (adjusted HR, 2.23; 95% CI, 1.42-3.52; p = 0.001). The effect of the interaction between ACI and RDW on CV events and mortality was statistically significant (p = 0.005). Conclusion: High RDW and VC interact to increase the risk of CV events and death in ESKD patients.

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Commonly available hematological biomarkers are associated with the extent of coronary calcifications

Cited by 10 publications

References 38 publications

Monocyte to Lymphocyte Ratio, Neutrophil to Lymphocyte Ratio, and Red Cell Distribution Width are the Associates with Gouty Arthritis

Monocyte to Lymphocyte Ratio, Neutrophil to Lymphocyte Ratio, and Red Cell Distribution Width are the Associates with Gouty Arthritis

Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease

The combined clinical impact of red blood cell distribution width and vascular calcification on cardiovascular events and mortality in patients with endstage kidney disease

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