Community-acquired methicillin-resistant Staphylococcus aureus pyomyositis in an intravenous drug user

Abstract

Pyomyositis is a disease of abscess formation deep within large striated muscles. Outside of the tropics it is a rare disease which occurs mainly in certain patient populations such as the immunosuppressed or intravenous drug users (IDUs). A case of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) pyomyositis in an IDU is described. The incidence of both CA-MRSA and pyomyositis is currently increasing. To the authors' knowledge this is the first reported case of CA-MRSA pyomyositis in the UK. Cases of CA-MRSA pyomyositis are likely to increase and it may be necessary to empirically treat certain patients with glycopeptides.

Increased Oxacillin Resistance in Thigh Pyomyositis in Diabetic Patients

“…Therefore, our study demonstrates that valid concerns were raised by recent studies reporting the emergence of community-acquired oxacillinresistant S. aureus as an important cause of pyomyositis [17,28,32]. Empiric antibiotic therapy should provide coverage for oxacillin-resistant S. aureus.…”

“…Literature on pyomyositis points out that S. aureus is the most common organism [4,12,13,15], however, recent studies have reported infections due to Gram-negative organisms [15,34,36], and oxacillin-resistant S. aureus [17,28,32]. We determined the rate of such infections due to oxacillin-resistant Staphylococcus aureus and Gram-negative organism infections, and asked whether the occurrence of oxacillinresistant pathogens increased during the study period.…”

“…Recent studies also reported the emergence of oxacillin-resistant S. aureus as a pyomyositis pathogen [17,28,32], and suggested that empiric antibiotic therapy may need to include a glycopeptide in high-risk patients such as intravenous drug users [17].…”

Outbreak of wound botulism in injecting drug users

“…Parenteral drug use is well known for carrying the risk of transmission of several infectious diseases [26][27][28][29]. Wound botulism is of special importance for two reasons : first, the clinical course is often severe and life-threatening, and second, the rarity of the disease renders diagnosis difficult.…”

Kalca Eklemi Cevresi Yumusak Dokulari

“…Nadir görülmesi ve non-spesifik klinik özellikleri nedeniyle tanısı sıklıkla gecikir [20]. Klinik seyrin ilk aşaması invaziv faz olup enfeksiyonun ilk 2-3 haftasında görülür.…”