Community-acquired pneumonia in adults: Highlighting missed opportunities for vaccination

Blasi, Francesco; Akova, Murat; Bonanni, Paolo; Dartois, Nathalie; Sauty, Evelyne; Webber, Chris; Torres, Antoni

doi:10.1016/j.ejim.2016.09.024

Cited by 22 publications

(13 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Around 50% of all CAP occurs in adults older than 65 years of age (23). Severe sepsis may be present in approximately one-third of all patients with community acquired pneumonia (CAP) at the time of admission to the emergency room (18).…”

Section: Epidemiological Characteristics Of Frequently Seen Infectionmentioning

confidence: 99%

“…Recommendations for preventing against S. pneumoniae infections vary between countries, but usually include sequential application of 13 valent conjugated pneumococcal vaccine given before 23-valent polysaccharide vaccine (11). Recommended age for these vaccines again differs by countries, but usually is for those >65 years (23). Annual vaccination against influenza with tri- or quadri-valent vaccine is recommended for those >60, however in some European countries (e.g., Austria, Czech Republic, Malta, Slovenia) and in US, the vaccine is available without any age restrictions (>6 months).…”

Section: Management Of Infected Critically-ill Elderly Patientmentioning

confidence: 99%

See 1 more Smart Citation

Infections in the Elderly Critically-Ill Patients

et al. 2019

Self Cite

View full text Add to dashboard Cite

Infections are leading causes of morbidity and mortality in the advanced aged. Various factors including immunosenescens, comorbid chronic diseases, and alterations in normal physiological organ functions may modify the frequency and severity of infections in elderly patients. Normal body reactions to ensuing infection, such as increased body temperature, may be blunted in those patients causing difficulties in differential diagnosis between infection and other diseases. In severe infections the respiratory and urinary tracts are the most frequently involved systems which may be accompanied by severe sepsis. Bacteremia and sepsis are also associated with indwelling vascular catheters in the elderly who are admitted to the intensive care unit (ICU). Older patients are more vulnerable to the Clostridioides difficile infection, as well. Although the general management of infections in severely ill elderly patients is not different than in younger patients, meticulous care in fluid management and careful individualized optimization in antibiotic therapy, along with the other principals of antimicrobial stewardship are warranted in order to prevent increased mortality caused by infection. Organized team management when treating critically ill elderly patients in the ICU is essential and will reduce the morbidity and mortality due to infection in such patients.

show abstract

Section: Epidemiological Characteristics Of Frequently Seen Infectionmentioning

confidence: 99%

Section: Management Of Infected Critically-ill Elderly Patientmentioning

confidence: 99%

Infections in the Elderly Critically-Ill Patients

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, despite the free and active offer of vaccination, coverage rates in adults are still very low, following a trend also observed in other countries [ 16 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 71%

Pneumococcal Colonization in the Familial Context and Implications for Anti-Pneumococcal Immunization in Adults: Results from the BINOCOLO Project in Sicily

Tramuto

Amodio

Calamusa

et al. 2017

IJMS

View full text Add to dashboard Cite

The spread of Streptococcus pneumoniae within families has been scarcely investigated so far. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-aged children and co-habiting relatives and to explore the potential link between the family environment and the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of 146 subjects belonging to 36 different family groups were molecularly tested for pneumococcal detection and serotyping. The overall prevalence of pneumococcal carriage was 65.8% (n = 96/146), whereas it was higher among schoolchildren (77.8%, n = 28/36); subjects of seven years of age had the highest odds of being colonized (odds ratio, OR = 5.176; p = 0.145). Pneumococcal serotypes included in the 13-valent conjugate vaccine formulation were largely detected in the study population and multiple serotypes colonization was considerable. Factors relating to a close proximity among people at the family level were statistically associated with pneumococcal carriage (OR = 2.121; p = 0.049), as well as active smoking habit with a clear dose-response effect (ORs = 1.017–3.326). About half of family clusters evidenced similar patterns of carried pneumococcal serotypes and the odds of sustaining a high level of intrafamilial sharing increased with household size (ORs = 1.083–5.000). This study highlighted the potential role played by the family environment in sustaining both the circulation and horizontal transmission of pneumococcus.

show abstract

“…Given the difficulty of immunizing adult patients [12], the PC consultation is a favourable environment for detecting patients who may be good candidates for vaccination and for taking advantage of the patient monitoring and quality control that nurses provide [13]. It has also been noted that patients have greater satisfaction with family doctors [14].…”

Section: Introductionmentioning

confidence: 99%

Differences between diabetic and non-diabetic patients with community-acquired pneumonia in primary care in Spain

Fernández

Pardo-Seco²,

Cebey-López³

et al. 2019

BMC Infect Dis

View full text Add to dashboard Cite

BackgroundDiabetes is one of the underlying risk factors for developing community-acquired pneumonia (CAP). The high prevalence of diabetes among population and the rising incidence of this illness, converts it as an important disease to better control and manage, to prevent its secondary consequences as CAP.The objective of this research is to describe the characteristics of the patients with diabetes and the differences with the no diabetes who have had an episode of CAP in the context of the primary care field.MethodsA retrospective, observational study in adult patients (> 18 years-old) who suffer from CAP and attended at primary care in Spain between 2009 and 2013 was developed using the Computerized Database for Pharmacoepidemiological Studies in Primary Care (BIFAP). We carried out a descriptive analysis of the first episodes of CAP, in patients with or without diabetes as comorbidity. Other morbidity (CVA, Anaemia, Arthritis, Asthma, Heart disease, Dementia, Depression, Dysphagia, Multiple sclerosis, Epilepsy, COPD, Liver disease, Arthrosis, Parkinson’s disease, Kidney disease, HIV) and life-style factors were also included in the study.ResultsA total of 51,185 patients were included in the study as they suffer from the first episode of CAP. Of these, 8012 had diabetes as comorbidity. There were differences between sex and age in patients with diabetes. Patients without diabetes were younger, and had less comorbidities including those related to lifestyles such as smoking, alcoholism, social and dental problems than patients with diabetes.ConclusionsPatients who developed an episode of CAP with diabetes have more risk factors which could be reduced with an appropriate intervention, including vaccination to prevent successive CAP episodes and hospitalization.The burden of associated factors in these patients can produce an accumulation of risk. Health care professional should know this for treating and control these patients in order to avoid complications. Diabetes and those other risk factors associated could be reduced with an appropriate intervention, including vaccination to prevent the first and successive CAP episodes and the subsequent hospitalization in severe cases.

show abstract

Community-acquired pneumonia in adults: Highlighting missed opportunities for vaccination

Cited by 22 publications

References 65 publications

Infections in the Elderly Critically-Ill Patients

Infections in the Elderly Critically-Ill Patients

Pneumococcal Colonization in the Familial Context and Implications for Anti-Pneumococcal Immunization in Adults: Results from the BINOCOLO Project in Sicily

Differences between diabetic and non-diabetic patients with community-acquired pneumonia in primary care in Spain

Contact Info

Product

Resources

About