Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents

Tsuji, Brian T.; Rybak, Michael J.; Cheung, Chrissy M.; Amjad, Muhammad; Kaatz, Glenn W.

doi:10.1016/j.diagmicrobio.2006.10.021

Cited by 94 publications

(54 citation statements)

References 28 publications

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“…A number of studies have linked alterations in agr activation or function with vancomycin tolerance, an increased tendency to develop vancomycin resistance, and the presence of the hVISA or VISA phenotype (121,269,295,296,357). In a number of these studies, determinations of agr activity were performed by the analysis of delta-hemolysin production on sheep blood agar; however, this is only a semiquantitative measure (296).…”

Section: Accessory Gene Regulator (Agr)mentioning

confidence: 99%

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

et al. 2010

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SUMMARY The emergence of vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) over the past decade has provided a challenge to diagnostic microbiologists to detect these strains, clinicians treating patients with infections due to these strains, and researchers attempting to understand the resistance mechanisms. Recent data show that these strains have been detected globally and in many cases are associated with glycopeptide treatment failure; however, more rigorous clinical studies are required to clearly define the contribution of hVISA to glycopeptide treatment outcomes. It is now becoming clear that sequential point mutations in key global regulatory genes contribute to the hVISA and VISA phenotypes, which are associated predominately with cell wall thickening and restricted vancomycin access to its site of activity in the division septum; however, the phenotypic features of these strains can vary because the mutations leading to resistance can vary. Interestingly, changes in the staphylococcal surface and expression of agr are likely to impact host-pathogen interactions in hVISA and VISA infections. Given the subtleties of vancomycin susceptibility testing against S. aureus, it is imperative that diagnostic laboratories use well-standardized methods and have a framework for detecting reduced vancomycin susceptibility in S. aureus.

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Section: Accessory Gene Regulator (Agr)mentioning

confidence: 99%

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

et al. 2010

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“…Our aim was to develop a simple and rapid screening method for heteroresistant vancomycin-intermediate Staphylococcus aureus (hVISA) and vancomycin-intermediate Staphylococcus aureus (VISA), based on ␦-hemolysin production, to correctly identify and distinguish hVISA and VISA from vancomycin-susceptible S. aureus (VSSA), based on the observations that hVISA and VISA are characterized by a decreased functionality of the regulatory agr (accessory gene regulator) locus encoding ␦-hemolysin (1,2,7,8,(11)(12)(13)(14)(15).…”

Section: H Eteroresistant Vancomycin-intermediate Staphylococcus Aurementioning

confidence: 99%

A Novel δ-Hemolysis Screening Method for Detecting Heteroresistant Vancomycin-Intermediate Staphylococcus aureus and Vancomycin-Intermediate S. aureus

et al. 2012

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“…These infections are generally caused by MRSA isolates that harbor SCCmec types I, II, and III (38). Community-associated MRSA (CA-MRSA) isolates, which carry SCCmec type IV or V, are now prevalent and exceeded methicillin-susceptible S. aureus (MSSA) in skin and soft tissue infections (3,4,27,35). These isolates were reported to cause severe, often necrotizing, soft tissue infections and pneumonia (3,5,19,27).…”

mentioning

confidence: 99%

Role of SCC mec Type in Outcome of Staphylococcus aureus Bacteremia in a Single Medical Center

et al. 2009

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Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents

Cited by 94 publications

References 28 publications

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

Reduced Vancomycin Susceptibility inStaphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

A Novel δ-Hemolysis Screening Method for Detecting Heteroresistant Vancomycin-Intermediate Staphylococcus aureus and Vancomycin-Intermediate S. aureus

Role of SCC mec Type in Outcome of Staphylococcus aureus Bacteremia in a Single Medical Center

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