Onitsha is one of the largest commercial cities in Africa with its population growth rate increasing arithmetically for the past two decades. This situation has direct and indirect effects on the natural resources including vegetation and water. The study aimed at assessing land use-land cover (LULC) change and its effects on the vegetation and landscape from 1987 to 2015 using geoinformatics. Supervised and unsupervised classifications including maximum likelihood algorithm were performed using ENVI 4.7 and ArcGIS 10.1 versions. The LULC was classified into 7 classes: built-up areas (settlement), waterbody, thick vegetation, light vegetation, riparian vegetation, sand deposit (bare soil) and floodplain. The result revealed that all the three vegetation types decreased in areas throughout the study period while, settlement, sand deposit and floodplain areas have remarkable increase of about 100% in 2015 when compared with the total in 1987. Number of dominant plant species decreased continuously during the study. The overall classification accuracies in 1987, 2002 and 2015 was 90.7%, 92.9% and 95.5% respectively. The overall kappa coefficient of the image classification for 1987, 2002 and 2015 was 0.98, 0.93 and 0.96 respectively. In general, the average classification was above 90%, a proof that the classification was reliable and acceptable.