Community‐dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project

Hsu, Benjumin; Bleicher, Kerrin; Waite, Louise M.; Naganathan, Vasi; Blyth, Fiona; Handelsman, David J.; Couteur, David G. Le; Seibel, Markus J.; Cumming, Robert

doi:10.1111/ggi.13516

Cited by 18 publications

(13 citation statements)

References 32 publications

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“…This finding is also consistent with our results that the osteoporosis group had a 1.27-fold higher risk of AD (95% CI = 1.22–1.32) than the matched control group (incidence rates: 10.4 and 6.8 per 1,000 person-years, respectively). However, some studies have reported results contradicting the association between AD or dementia and osteoporosis (Guo et al, 2012 ; Hsu et al, 2018 ), but these studies did not include a general population without osteoporosis as a control and had selection bias, as they evaluated either only older men aged 70–94 years or psychiatric patients.…”

Section: Discussionmentioning

confidence: 99%

The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

Kwon

Kim

et al. 2021

Front. Aging Neurosci.

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Background: Public health concerns regarding the potential link between osteoporosis and the increased occurrence of Alzheimer’s disease (AD) and Parkinson’s disease (PD) have been raised, but the results remain inconsistent and require further validation. Here, we investigated the long-term relationship of osteoporosis with the occurrence of AD/PD using data from a large-scale nationwide cohort.Methods: This longitudinal follow-up study included 78,994 patients with osteoporosis and 78,994 controls from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015) who were matched using propensity score matching at a 1:1 ratio based on age, sex, income, and residential area. A Cox proportional hazard model was used to assess the association between osteoporosis and the occurrence of AD/PD after adjusting for multiple covariates.Results: During the follow-up period, AD occurred in 5,856 patients with osteoporosis and 3,761 controls (incidence rates: 10.4 and 6.8 per 1,000 person-years, respectively), and PD occurred in 1,397 patients and 790 controls (incidence rates: 2.4 and 1.4 per 1,000 person-years, respectively). The incidences of AD and PD were significantly higher in the osteoporosis group than in the matched control group. After adjustment, the osteoporosis group exhibited 1.27-fold and 1.49-fold higher occurrences of AD (95% confidence interval (CI) = 1.22–1.32) and PD (95% CI = 1.36–1.63) than the controls, respectively. The results of subgroup analyses supported the increased occurrence of AD and PD in patients with osteoporosis, independent of income, residential area, obesity, smoking, alcohol consumption, hyperlipidemia, hypertension, or blood glucose level.Conclusion: Our results indicate that the presence of osteoporosis may increase the likelihood of developing two common neurodegenerative diseases in adults aged ≥40 years.

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Section: Discussionmentioning

confidence: 99%

The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

Kwon

Kim

et al. 2021

Front. Aging Neurosci.

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“…Likewise, in some studies, comorbidities are noted to be associated with falls, and in others, there is no association (Galik, Holmes, & Resnick, 2018;Urrunaga-Pastor et al, 2018). Cognitive status tends to be associated with falls such that those who are impaired, particularly those with mild impairment, are more likely to sustain a fall (Hsu et al, 2018). In the current study, we used the single three out of three word recall item from the Mini-Cog to describe cognitive status, and this may not have been sensitive enough to differentiate those with mild, moderate, or severe impairment.…”

Section: Discussionmentioning

confidence: 99%

Impact of Function Focused Care and Physical Activity on Falls in Assisted Living Residents

et al. 2019

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Background There continues to be a belief among nurses, patients, and families that physical activity increases the risk of falling. Purpose The purpose of this study was to test the hypothesis that controlling for age, function, cognition, medication use, gender, comorbidities, and cognition, residents who are exposed to Function Focused Care for Assisted Living (FFC-AL-EIT) and engage in moderate levels of physical activity would not be more likely to fall. Methods This was a secondary data analysis using data from the first two cohorts of a randomized trial testing FFC-AL-EIT in the United States. Results The study included 381 residents, the majority of whom were female (70%), white (97%), with a mean age of 87.72 (standard deviation = 7.47). Those who engaged in more moderate-intensity physical activity were 1% less likely to fall (odds ratio = .99, p = .03). There was no significant association between exposure to function focused care and falling (odds ratio = 1.58, p = .09). Conclusion There was no indication that those who were exposed to function focused care or those who engaged in moderate-level physical activity were more likely to fall. In fact, engaging in moderate-level physical activity was noted to be slightly protective of falling.

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“…32,33,[35][36][37][38][39][40][41][42][43][44][45][46] The mean age of participants with Mild Cognitive Impairment was 75.1 years (standard deviation 5.9). Females ranged from 0% 34 to 100% 47 of the sample, with the average being 59% (standard deviation 18.4).…”

Section: Study Characteristicsmentioning

confidence: 99%

Prevalence, risk factors and effectiveness of falls prevention interventions for adults living with Mild Cognitive Impairment in the community: A systematic review and meta-analysis

2022

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Objectives To identify falls prevalence, falls risk factors and evaluate the effectiveness of falls prevention interventions for community-dwelling people with Mild Cognitive Impairment. Data sources Peer-reviewed articles (inception to 4 August 2022) from PubMed, CINAHL, PsycInfo, EMBASE, Scopus, SportDiscus and the Cochrane library. Review methods All types of methodological approaches were considered. Inclusion criteria were community-dwelling; diagnosis of Mild Cognitive Impairment; aged 50+ years. Interventions needed to include falls prevention programs aiming to reduce falls and/or risk of falls. Outcomes of interest included number and/or rate of falls, falls prevalence and falls risk factors. For controlled trials, any control group was included. Quality assessment was completed using Cochrane's Risk of Bias Tool for randomized controlled trials and the Standard Quality Assessment Criteria for Evaluating Primary Research Papers from a Variety of Fields for all other studies. Where statistical data pooling was not possible, narrative synthesis was used to present data in tables and figures. Results Forty-seven studies were included. Prevalence of falls was 43% when data were gathered prospectively for 12 months. Confirmed falls risk factors included slow gait, dual-tasking, postural control and non-amnesic Mild Cognitive Impairment. Few studies evaluated interventions to reduce falls. Six meta-analyses were conducted, no significant reduction in falls was found. Conclusions Until further high-quality, adequately powered studies are available to guide practice, best practice guidelines recommend balance training as a core component of falls prevention programs for older people generally, as well as people with Mild Cognitive Impairment.

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Community‐dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project

Abstract: Older men with dementia, but not MCI, have a greater tendency to fall and sustain hip fractures, but not any other types of fractures. Geriatr Gerontol Int 2018; 18: 1479-1484.

Cited by 18 publications

References 32 publications

The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

The Occurrence of Alzheimer’s Disease and Parkinson’s Disease in Individuals With Osteoporosis: A Longitudinal Follow-Up Study Using a National Health Screening Database in Korea

Impact of Function Focused Care and Physical Activity on Falls in Assisted Living Residents

Prevalence, risk factors and effectiveness of falls prevention interventions for adults living with Mild Cognitive Impairment in the community: A systematic review and meta-analysis

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