Community Outbreak of Adenovirus, Taiwan, 2011

Tsou, Tsung-Pei; Tan, Boon-Fatt; Chang, Hsin-Yu; Chen, Wan-Chin; Huang, Yuanyuan; Lai, Chih Cheng; Chao, Yen-Nan; Wei, Sung-Hsi; Hung, Min-Nan; Hsu, Li-Chuan; Lu, Chun‐Yi; Shao, Pei-Lan; Mu, Jung-Jung; Chang, Luan‐Yin; Liu, Ming‐Tsan; Huang, Li‐Min

doi:10.3201/eid1811.120629

Cited by 69 publications

(87 citation statements)

References 32 publications

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“…A similar study in which high HAdV infections (47.6%) were shown at the age group ≤ 1 to ≥3 years compared to age group 3-≤ 6 years and 6-≤ 15 years at 28.1%, 11%, respectively [35]. The study finding is also, comparable to other studies of HAdV infection in other part of the world indicating that children under the age of 3 years were most susceptible to HAdV infection [36][37][38]. In previous experiments for the detection of HAdV in RTI, we observed that Children at age between 6 to 15 years usually have a lower rate of infection.…”

Section: Molecular Diagnosis Of Human Adenovirus In Children With Uppsupporting

confidence: 80%

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Khalaf¹,

Fadhil²,

Auf³

et al. 2017

IOSRJPBS

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Section: Molecular Diagnosis Of Human Adenovirus In Children With Uppsupporting

confidence: 80%

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Khalaf¹,

Fadhil²,

Auf³

et al. 2017

IOSRJPBS

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“…A corresponding rise was noted among military personnel during October 2012-April 2013, but no statistically significant increase in Ad7 infections was detected by the NPHL community ILI surveillance program. Partial hexon gene sequences of the Singapore isolates had 100% nucleotide identity with sequences reported from outbreaks in Taiwan and China (2,3,10).…”

Section: Discussionmentioning

confidence: 92%

“…Recent reports have noted increased incidence of severe Ad7 disease in Asia: among the general population and pediatric inpatients in Taiwan; among persons in a military training camp in Shaanxi, China; and among those in a police training center in Kuala Lumpur, Malaysia (2)(3)(4). During January-June 2013, physicians in Singapore noted an increase in HAdV pediatric inpatients.…”

mentioning

confidence: 99%

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Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia

Ng¹,

Thoon²,

Chua³

et al. 2015

Emerg. Infect. Dis.

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“…Thus, control of HAdV7 spread is crucial. However, it is difficult to differentiate pneumonia caused by HAdVs from other types of viral pneumonia, and culturing and typing of HAdVs are not routinely performed in hospitals (18). Therefore, the inevitable delay of several days in the recognition of HAdV infections probably promoted the transmission.…”

mentioning

confidence: 99%

Human Adenovirus Type 7 Infection Associated with Severe and Fatal Acute Lower Respiratory Illness and Nosocomial Transmission

Cui

Wen

et al. 2015

J Clin Microbiol

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A 23-year-old male died of severe pneumonia and respiratory failure in a tertiary hospital in Beijing, and 4 out of 55 close contacts developed fever. Molecular analysis confirmed human adenovirus type 7 (HAdV7) as the causative agent. We highlight the importance of early diagnosis and treatment and proper transmission control of HAdV7. CASE REPORT Human adenovirus type 7 (HAdV7) infection is associated with acute respiratory disease syndrome, pharyngoconjunctival fever, pneumonia, and central nervous system disease (1-4). According to the last global survey, approximately one-fifth of all HAdV infections reported to the World Health Organization (WHO) were attributed to HAdV7 (5). HAdV7 outbreaks generally occur in settings with close living conditions, such as military barracks, hospital wards, and chronic care facilities (1,(6)(7)(8). In hospitals, HAdV has emerged as a nosocomial pathogen, and nosocomial outbreaks caused by HAdV7 with fatal cases have been reported worldwide (8-10). Although some prevention measurements have been carried out to control nosocomial transmission, questions regarding the efficacy of these programs persist, and the contribution of HAdV7 (and adenoviruses in general) to nosocomial infection is likely to be underestimated. Here, we report a case of HAdV7 infection associated with severe pneumonia and fatal acute lower respiratory disease and nosocomial transmission.The index case, a 23-year-old male in Wuhan City, Hubei Province, China, presented with a fever of approximately 39°C on 18 January 2014, but discontinuous treatment did not alleviate his symptoms. On 26 January, he was admitted to the emergency department of a tertiary hospital in Beijing. A routine blood test showed high neutrophil levels (71.4%) and elevated plasma C reactive protein (19 mg/ml), and chest radiographs revealed an increase of right lung markings. However, the use of cefoxitin sodium by injection did not prevent his condition from worsening, with symptoms including severe fever, cough, and phlegm. He was diagnosed with pneumonia and transferred to the respiratory department on 28 January. Six days later, he was transferred to an intensive care unit (ICU) because of lung consolidation, and he passed away on 5 February 2014.During his hospitalization, 4 of 55 close contacts developed fevers higher than 38.0°C, including a family member, a bedside clinician, and two patients in the same ward (Table 1 and Fig. 1). The initial secondary case (patient 1) was his cousin, a 19-year-old girl who visited the index case on 26 January for 30 min in the emergency department and on 2 February for 5 min in the respiration department. The distance between them was more than 2 meters, but neither wore a mask. She experienced a fever of 38.5°C on 3 February. Patient 2, a 29-year-old male with acute pancreatitis and a fatty liver, was admitted to the same ward of the emergency department on 27 January. He developed a fever on 3 February, and a chest X-ray showed pulmonary shadows. Patient 3, a bedside clinician of the inde...

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Community Outbreak of Adenovirus, Taiwan, 2011

Abstract: Adenovirus type 7 caused a high proportion of severe infections.

Cited by 69 publications

References 32 publications

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia

Human Adenovirus Type 7 Infection Associated with Severe and Fatal Acute Lower Respiratory Illness and Nosocomial Transmission

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