This research is motivated by the importance of sustainable tourism aspects in achieving the Sustainable Development Goals (SDGs) which countries around the world have adopted this concept. This study is focused on Tourism Objects in South Kalimantan Province as a tourism destination in Indonesia. The method used in this research is an empirical study method with a quantitative approach. The technique used is a proportional sample with the help of the SEM (Structural Equation Modeling) program which is operated through the SmartPLS program. This study uses the formula Hair, et.al., (1995) with the provisions of 5 x 43 item parameters times the number of research questionnaires, namely 215 research samples. Methods of data collection using a questionnaire. The research hypothesis was tested using the Partial Least Square (PLS) based Structural Equation Model (SEM) approach. Society participation, Tourism Social Entrepreneurship, Destination Governance and Innovation have a significant effect on Sustainable Tourism. Furthermore, Society participation, Tourism Social Entrepreneurship, Destination Governance have a significant effect on Innovation. And Innovation mediates the relationship between Society participation, Tourism Social Entrepreneurship, and Destination Governance towards Sustainable Tourism. This study is expected to provide a better understanding of how innovation can be an important factor in achieving sustainable tourism in South Kalimantan.