Comorbid diseases of vitiligo: A 10-year cross-sectional retrospective study of an urban US population

Hadi, Ali; Wang, Jason F.; Uppal, Pushpinder; Penn, Lauren; Elbuluk, Nada

doi:10.1016/j.jaad.2019.07.036

Cited by 34 publications

(34 citation statements)

References 18 publications

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“…Although the interplay between the intestinal microbiome and the autoimmune state has never been investigated in vitiligo, a putative connection between vitiligo and intestinal microbiome essentially exists. It has been noted that vitiligo patients have a high rate of comorbidity with inflammatory bowel disease (IBD) (Hadi et al, 2019), another autoimmune disease associated with aberrant intestinal microbiome (Gevers et al, 2014;Lloyd-Price et al, 2019). Furthermore, the proposed concept of the gut-skin axis provides a plausible correlation between gut microbiome and dermatoses, which has been reiterated in two autoimmune skin diseases including psoriasis (Hidalgo-Cantabrana et al, 2019) and atopic dermatitis (Mahdavinia et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbial Dysbiosis and Plasma Metabolic Profile in Individuals With Vitiligo

Wang

et al. 2020

Front. Microbiol.

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Autoimmune diseases are increasingly linked to aberrant gut microbiome and relevant metabolites. However, the association between vitiligo and the gut microbiome remains to be elucidated. Thus, we conducted a case-control study through 16S rRNA sequencing and serum untargeted-metabolomic profiling based on 30 vitiligo patients and 30 matched healthy controls. In vitiligo patients, the microbial composition was distinct from that of healthy controls according to the analysis on α- and β-diversity (P < 0.05), with a characteristic decreased Bacteroidetes: Firmicutes ratio. Meanwhile, the levels of 23 serum metabolites (including taurochenodeoxycholate and L-NG-monomethyl-arginine) in the vitiligo patients were different from those in the healthy individuals and showed significant correlations with some microbial markers. We found that Corynebacterium 1, Ruminococcus 2, Jeotgalibaca and Psychrobacter were correlated significantly with disease duration and serum IL-1β level in vitiligo patients. And Psychrobacter was identified as the most predictive features for vitiligo by machine learning analysis (“importance” = 0.0236). Finally, combining multi-omics data and joint prediction models with accuracies up to 0.929 were established with dominant contribution of Corynebacterium 1 and Psychrobacter. Our findings replenished the previously unknown relationship between gut dysbiosis and vitiligo circulating metabolome and enrolled the gut-skin axis into the understanding of vitiligo pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Gut Microbial Dysbiosis and Plasma Metabolic Profile in Individuals With Vitiligo

Wang

et al. 2020

Front. Microbiol.

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“…Although vitiligo is not life-threatening, it is associated with a significant psychological burden for patients (4) and it may result in large financial costs for public health systems. In fact, it is estimated that the cost of vitiligo is ~175 million dollars per year in the USA (5). The pathogenesis of vitiligo remains unclear and currently, there is no gold standard treatment for the disease (6).…”

Section: Introductionmentioning

confidence: 99%

ZMIZ1 promotes the proliferation and migration of melanocytes in vitiligo

Fan

Wang

et al. 2020

Exp Ther Med

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Genome wide association studies have revealed that the zinc finger MIZ-type containing 1 (ZMIZ1) is involved in the pathogenesis of vitiligo; however, the underlying mechanism remains unclear. The present study aimed to investigate the effects of ZMIZ1 on the proliferation, apoptosis and migration of the human melanocyte cell lines PIG1 and PIG3V. ZMIZ1 overexpression and knockdown PIG1 and PIG3V cell models were established by lentivirus infection, and the effects of ZMIZ1 on cell proliferation and apoptosis were determined using an MTT assay and flow cytometry, respectively. Furthermore, the expression levels of proliferation-and apoptosis-associated proteins were analyzed using western blotting. Additionally, Transwell assays were performed to determine the effect of ZMIZ1 on the migration of PIG1 and PIG3V cells. Finally, the effect of ZMIZ1 on cytoskeletal remodeling in PIG1 and PIG3V cells was analyzed using immunocytochemistry. The overexpression of ZMIZ1 promoted the proliferation and inhibited the apoptosis of PIG1 and PIG3V cells, whereas the genetic knockdown of ZMIZ1 resulted in the opposite effects. Furthermore, ZMIZ1 overexpression increased the migration, whereas the knockdown of ZMIZ1 inhibited the migration and altered remodeling of the actin cytoskeleton in PIG1 and PIG3V cells. In conclusion, the results of the present study suggest that ZMIZ1 regulates the proliferation, apoptosis and migration of PIG1 and PIG3V cells, and indicate that ZMIZ1 may serve as a potential therapeutic target for vitiligo.

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“…In previous studies, 14-55% of patients with vitiligo were found to have comorbid autoimmune conditions. Associated autoimmune conditions include inflammatory bowel disease, pernicious anemia, systemic lupus erythematosus, thyroid disease, and less commonly, Sjogren's syndrome (Table 1) [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

Vitiligo as the Presenting Manifestation of Sjogren’s Syndrome: Case Report and Review of Vitiligo and Its Associated Autoimmune Conditions

Gutierrez

Cohen²

2020

Cureus

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Vitiligo is a cutaneous condition that causes loss of pigmentation; it can be associated with other autoimmune conditions. Sjogren’s syndrome is a chronic inflammatory autoimmune condition that classically presents with xerophthalmia and xerostomia. Rarely, vitiligo has occurred in individuals with Sjogren’s syndrome. A 51-year-old Hispanic woman presented with vitiligo. Her laboratory investigation was consistent with Sjogren’s syndrome; she subsequentially developed xerophthalmia and arthritis. The association between vitiligo and other autoimmune conditions is reviewed and the association of vitiligo and Sjogren’s syndrome is discussed.

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Comorbid diseases of vitiligo: A 10-year cross-sectional retrospective study of an urban US population

Cited by 34 publications

References 18 publications

Gut Microbial Dysbiosis and Plasma Metabolic Profile in Individuals With Vitiligo

Gut Microbial Dysbiosis and Plasma Metabolic Profile in Individuals With Vitiligo

ZMIZ1 promotes the proliferation and migration of melanocytes in vitiligo

Vitiligo as the Presenting Manifestation of Sjogren’s Syndrome: Case Report and Review of Vitiligo and Its Associated Autoimmune Conditions

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