Comorbid symptoms of inattention, autism, and executive cognition in youth with putative genetic risk

Arnett, Anne B.; Cairney, Brianna E.; Wallace, Arianne S.; Gerdts, Jennifer; Turner, Tychele N.; Eichler, Evan E.; Bernier, Raphael

doi:10.1111/jcpp.12815

Cited by 9 publications

(7 citation statements)

References 70 publications

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“…The presence of nonadditive patterns points to unique processing or additional factors underlying the cognitive performance in comorbid patients. Previous studies found that co-occurring symptoms of ASD and ADHD are explained by not only overlapping genetic factors of the pure disorders (Arnett et al, 2018) but also distinct gene-environmental influences (Kröger et al, 2011; Rommelse et al, 2010; Ronald, Simonoff, Kuntsi, Asherson, & Plomin, 2008). More research is warranted to better understand the status of comorbid ADHD and ASD.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies found that co-occurring symptoms of ASD and ADHD are explained by overlapping genetic factors of the pure disorders (Arnett et al, 2017) but also distinct gene-environmental influences (Ronald et al, 2008;Rommelse, Franke et al, 2010;Kröger et al, 2011). More research is warranted to better understand the status of comorbid ADHD and ASD.…”

Section: 4mentioning

confidence: 99%

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Examining the Overlap Between ADHD and Autism Spectrum Disorder (ASD) Using Candidate Endophenotypes of ADHD

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: 4mentioning

confidence: 99%

Examining the Overlap Between ADHD and Autism Spectrum Disorder (ASD) Using Candidate Endophenotypes of ADHD

et al. 2018

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“…High levels of hyperactive/impulsive behaviour are common in children with learning‐related difficulties (Hawkins, Gathercole, Astle, The Calm, & Holmes, 2016); indeed, in some cases elevated inattention can be as common as in children with ADHD (Bathelt et al., 2018; Holmes et al., 2014; Willcutt, Pennington, Olson, & DeFries, 2007). In addition, both hyperactive / impulsive behaviours and inattention are common in autistic children (Arnett et al., 2018; van Steijn et al., 2012). Taxometry provides further evidence that both kinds of behaviour are distributed continuously across the population as a whole (Marcus & Barry, 2011).…”

Section: New Transdiagnostic Approachesmentioning

confidence: 99%

Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders

Astle

Holmes

Kievit

et al. 2021

Child Psychology Psychiatry

186

117

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Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental disorders and to guide intervention decisions. These criteria also provide the organising framework for much of the research focussing on these disorders. Study design, recruitment, analysis and theory are largely built on the assumption that diagnostic criteria reflect an underlying reality. However, there is growing concern that this assumption may not be a valid and that an alternative transdiagnostic approach may better serve our understanding of this large heterogeneous population of young people. This review draws on important developments over the past decade that have set the stage for much-needed breakthroughs in understanding neurodevelopmental disorders. We evaluate contemporary approaches to study design and recruitment, review the use of data-driven methods to characterise cognition, behaviour and neurobiology, and consider what alternative transdiagnostic models could mean for children and families. This review concludes that an overreliance on ill-fitting diagnostic criteria is impeding progress towards identifying the barriers that children encounter, understanding underpinning mechanisms and finding the best route to supporting them.

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“…ASD starts in early childhood around the age of 3 years and persists throughout life [ 79 ]. People with ASD commonly experience other comorbidities such as memory and learning deficits, seizures, motor incoordination, changes in sensory perception, anxiety, and sleep disturbances [ 80 – 82 ]. According to the data released by the Centers for Disease Control and Prevention (CDC) and Autism and Developmental Disabilities Monitoring network, about 1 in 44 (2.3%) children in the United States have been identified with autism in 2018 [ 83 ].…”

Section: Circadian Dysfunction Mtor and Asdmentioning

confidence: 99%

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

2022

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Circadian (~24 h) rhythms in physiology and behavior are evolutionarily conserved and found in almost all living organisms. The rhythms are endogenously driven by daily oscillatory activities of so-called “clock genes/proteins”, which are widely distributed throughout the mammalian brain. Mammalian (mechanistic) target of rapamycin (mTOR) signaling is a fundamental intracellular signal transduction cascade that controls important neuronal processes including neurodevelopment, synaptic plasticity, metabolism, and aging. Dysregulation of the mTOR pathway is associated with psychiatric disorders including autism spectrum disorders (ASD) and mood disorders (MD), in which patients often exhibit disrupted daily physiological rhythms and abnormal circadian gene expression in the brain. Recent work has found that the activities of mTOR signaling are temporally controlled by the circadian clock and exhibit robust circadian oscillations in multiple systems. In the meantime, mTOR signaling regulates fundamental properties of the central and peripheral circadian clocks, including period length, entrainment, and synchronization. Whereas the underlying mechanisms remain to be fully elucidated, increasing clinical and preclinical evidence support significant crosstalk between mTOR signaling, the circadian clock, and psychiatric disorders. Here, we review recent progress in understanding the trilateral interactions and propose an “interaction triangle” model between mTOR signaling, the circadian clock, and psychiatric disorders (focusing on ASD and MD).

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Comorbid symptoms of inattention, autism, and executive cognition in youth with putative genetic risk

Abstract: Comorbid symptoms of ASD, IA, and cognitive deficits are likely influenced by common neurogenetic factors. Known genetic risk in ASD may inform future investigation of putative genetic causes of IA.

Cited by 9 publications

References 70 publications

Examining the Overlap Between ADHD and Autism Spectrum Disorder (ASD) Using Candidate Endophenotypes of ADHD

Examining the Overlap Between ADHD and Autism Spectrum Disorder (ASD) Using Candidate Endophenotypes of ADHD

Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders

The trilateral interactions between mammalian target of rapamycin (mTOR) signaling, the circadian clock, and psychiatric disorders: an emerging model

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