Comorbidities associated with bladder dysfunction

Tannenbaum, Cara; Gray, Mikel; Hoffstetter, Susan; Cardozo, Linda

doi:10.1111/ijcp.12085

Cited by 21 publications

(17 citation statements)

References 134 publications

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“…The etiology of lower urinary tract symptoms may be singular or multifactorial, with potential contributors encompassing lifestyle habits, underlying bladder or pelvic floor dysfunction, associated co-morbidities and/or functional factors [5,6]. Many commonly used medications have been proposed to inadvertently interfere with bladder and/or sphincter function, or indirectly impair the ability to toilet [6,7].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of commonly prescribed medications potentially contributing to urinary symptoms in a cohort of older patients seeking care for incontinence

Kashyap

Tannenbaum

2013

BMC Geriatr

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BackgroundSeveral medication classes may contribute to urinary symptoms in older adults. The purpose of this study was to determine the prevalence of use of these medications in a clinical cohort of incontinent patients.MethodsA cross-sectional study was conducted among 390 new patients aged 60 years and older seeking care for incontinence in specialized outpatient geriatric incontinence clinics in Quebec, Canada. The use of oral estrogens, alpha-blocking agents, benzodiazepines, antidepressants, antipsychotics, ACE inhibitors, loop diuretics, NSAIDs, narcotics and calcium channel blockers was recorded from each patient’s medication profile. Lower urinary tract symptoms and the severity of incontinence were measured using standardized questionnaires including the International Consultation on Incontinence Questionnaire. The type of incontinence was determined clinically by a physician specialized in incontinence. Co-morbidities were ascertained by self-report. Logistic regression analyses were used to detect factors associated with medication use, as well as relationships between specific medication classes and the type and severity of urinary symptoms.ResultsThe prevalence of medications potentially contributing to lower urinary tract symptoms was 60.5%. Calcium channel blockers (21.8%), benzodiazepines (17.4%), other centrally active agents (16.4%), ACE inhibitors (14.4%) and estrogens (12.8%) were most frequently consumed. Only polypharmacy (OR = 4.9, 95% CI = 3.1-7.9), was associated with medication use contributing to incontinence in analyses adjusted for age, sex, and multimorbidity. No associations were detected between specific medication classes and the type or severity of urinary symptoms in this cohort.ConclusionThe prevalence of use of medications potentially causing urinary symptoms is high among incontinent older adults. More research is needed to determine whether de-prescribing these medications results in improved urinary symptoms.

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Section: Introductionmentioning

confidence: 99%

Prevalence of commonly prescribed medications potentially contributing to urinary symptoms in a cohort of older patients seeking care for incontinence

Kashyap

Tannenbaum

2013

BMC Geriatr

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“…The literature shows conflicting results regarding the association between hypertension and UI, which could be due to the fact that both conditions have increasing prevalences with aging and/or to the effect of medications used for hypertension treatment [21][22][23] . An association between the medications used for symptoms of the lower urinary tract and the UI subtypes was not found.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetic women can show urinary symptoms related to the clinical presentation of the disease or to the urinary tract dysfunction caused by diabetes 23 . Diabetes alone is one of the most relevant factors for the occurrence of UI, and patients may present, among others, symptoms of both SUI and MUI 22,[24][25] .…”

Section: Discussionmentioning

confidence: 99%

Diabetes and Vaginal Surgery Are Associated With Mixed Urinary Incontinence in Patients Treated in a Tertiary Unit of Rio De Janeiro Public Healthcare System

et al. 2017

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Introduction: Urinary incontinence (UI) is prevalent in women, and the frequency of its clinical subtypes varies according to the population studied and the choice of diagnostic criteria. The aim of this study was to evaluate the distribution of the most common subtypes -stress urinary incontinence (SUI) and mixed urinary incontinence (MUI) -and their correlation with demographic, clinical and reproductive factors of patients seen at the university hospital of Universidade Federal do Rio de Janeiro.

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“…Therefore, identification and subsequent treatment of MDD may aid in the prevention of future UI symptoms. [45]…”

Section: Discussionmentioning

confidence: 99%

Coexistence of urinary incontinence and major depressive disorder with health-related quality of life in older Americans with and without cancer

et al. 2014

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Purpose This study evaluates the prevalence and factors associated with major depressive disorder (MDD) in a population of cancer survivors and the impact of co-occurring MDD and urinary incontinence (UI) on health-related quality of life (HRQOL). Methods The prevalence of MDD risk among cancer survivors (breast, prostate, bladder, colorectal, lung and endometrial/uterine cancers) and those without cancer was estimated using the Surveillance, Epidemiology and End Results Program-Medicare Health Outcomes Survey (SEER-MHOS) linked database (n=9,282 with cancer/n=289,744 without cancer). Risk for MDD was measured using 3 items from the Diagnostic Interview Schedule and HRQOL was measured by the SF-36. UI was defined as self-reported leakage of urine causing a problem in previous 6 months. Factors associated with MDD were investigated using logistic regression and the impact of co-occurring MDD and UI on HRQOL scores was determined using linear regression. Results The prevalence of MDD risk ranged from 19.2% for prostate-34.1% for lung. Lung cancer diagnosis was associated with risk of MDD. Being ≥5 years from diagnosis was associated with decreased risk of MDD (Prevalence Odds Ratio (POR)=0.82, 95% Confidence Interval (95% CI): 0.71, 0.95). The coexistence of both UI and MDD was associated with a decrease across HRQOL subscales; including 40-points on role emotional (RE) score. Conclusions Cancer survivors reporting co-occurrence of UI and MDD experienced significant decrements in HRQOL. Implications of cancer survivors Understanding the combined effect of UI and MDD may help clinicians to better recognize and alleviate their effects on cancer survivors’ HRQOL.

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Comorbidities associated with bladder dysfunction

Cited by 21 publications

References 134 publications

Prevalence of commonly prescribed medications potentially contributing to urinary symptoms in a cohort of older patients seeking care for incontinence

Prevalence of commonly prescribed medications potentially contributing to urinary symptoms in a cohort of older patients seeking care for incontinence

Diabetes and Vaginal Surgery Are Associated With Mixed Urinary Incontinence in Patients Treated in a Tertiary Unit of Rio De Janeiro Public Healthcare System

Coexistence of urinary incontinence and major depressive disorder with health-related quality of life in older Americans with and without cancer

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