Comorbidities in alopecia areata: A systematic review and meta-analysis

Lee, Solam; Lee, Hanil; Lee, Chung Hyeok; Lee, Won‐Soo

doi:10.1016/j.jaad.2018.07.013

Cited by 151 publications

(179 citation statements)

References 89 publications

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“…Alopecia areata (AA) is a prevalent autoimmune disorder characterized by patchy hair loss and may be associated with medical comorbidities including atopy, thyroid, gastrointestinal, metabolic, and cardiovascular disease [1]. While AA is commonly thought to be a T-helper (Th)1 and cytotoxic T-cell-mediated nonscarring form of hair loss, it is often encountered in the presence of atopy.…”

Section: Introductionmentioning

confidence: 99%

The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

Sung

Choi

Juhász

et al. 2019

Skin Appendage Disord

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Background: While alopecia areata (AA) has been associated with atopy, the immunological relationship is unclear, with the association of specific atopic and systemic respiratory diseases not established. The relationship between T-helper (Th)1-mediated AA and Th2-mediated atopy challenges the conventional Th1/Th2 paradigm of autoimmune disease categorization. Objectives: To determine the association between AA and atopic respiratory diseases in adults and children, and respiratory diseases in general. Method: All primary literature, excluding case reports, were identified within PubMed/MEDLINE, CINAHL, and Web of Science in May 2018 using the following search terms: “(alopecia OR hair loss) AND (respiratory OR pulmonary OR lungs OR asthma OR rhinitis OR bronchitis OR COPD OR atopy OR atopic).” Information from 32 articles meeting the inclusion and exclusion criteria was reviewed. Results: Among the 32 articles identified for inclusion, the prevalence of AA was more strongly associated with allergic rhinitis compared to asthma among pediatric and adult populations. While a significant association was identified between AA, allergic rhinitis, and a late age of onset, the association of AA and asthma remains controversial despite asthma’s prevalence among AA patients. No significant difference was identified with regard to the association of AA and non-atopic respiratory diseases between adult and pediatric patients. Conclusions: Adult and pediatric patients with AA warrant further workup for atopic respiratory diseases such as allergic rhinitis. AA may have an underlying Th2-mediated immunological component, which supports its association with atopic respiratory diseases and provides a new avenue for targeted therapies in select cases.

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Section: Introductionmentioning

confidence: 99%

The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

Sung

Choi

Juhász

et al. 2019

Skin Appendage Disord

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“…It is emphasized that in many AA patients, there is a positive family history for other autoimmune diseases. Furthermore, atopic dermatitis is more frequently diagnosed in a group of patients with AA [10].…”

Section: Discussionmentioning

confidence: 99%

“…Podkreśla się, że wielu pacjentów z AA ma obciążający wywiad rodzinny w kierunku innych chorób autoimmunologicznych. Ponadto u chorych z AA częściej stwierdza się atopowe zapalenie skóry [10].…”

Section: Wnioskiunclassified

Autoimmune polyglandular syndrome type 4 – case report

Liszewska¹,

Robak²,

Bernacka³

et al. 2019

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Introduction. Autoimmune polyglandular syndromes (APS) are a group of disorders presenting diverse clinical pictures. They are characterized by concomitance of autoimmune diseases. Most of them are linked to dysfunction of endocrine glands, which are targeted by autoantibodies. Four main types of syndromes are described in the literature: APS-1, APS-2, APS-3, and APS-4. All of them are genetically determined. Objective. A case of 57-year-old woman is presented, in which APS-4 co-occures with generalized alopecia and rheumatoid arthritis. Case report. A fifty-seven-year-old woman with a 4-year history of leg ulcers was admitted to the Dermatology Clinic. The physical examination revealed a loss of eyebrows, eyelashes, the scalp hair and axillary hair. Antithyroid microsomal antibodies were found in the serum. For the last 15 years, she has been periodically treated for rheumatoid arthritis with sulfasalazine, methotrexate, and methylprednisolone. Conclusions. The report indicates that patients with a single organspecific autoimmune disease should be examined for other coexisting autoimmune disorders. STRESZCZENIE Wprowadzenie. Autoimmunologiczne zespoły niedoczynności wielogruczołowej (APS) to grupa schorzeń o zróżnicowanym obrazie klinicznym. Charakteryzują się współwystępowaniem wielu chorób autoimmunizacyjnych. Większość z nich skutkuje niedoczynnością gruczołów dokrewnych, które są niszczone przez autoprzeciwciała. Wyodrębnia się 4 typy zespołów: APS-1, APS-2, APS-3 i APS-4. Wszystkie są uwarunkowane genetycznie. Cel pracy. Przedstawiono przypadek 57-letniej kobiety chorującej na APS-4, u której współwystępowały łysienie plackowate uogólnione i reumatoidalne zapalenie stawów. Opis przypadku. Pięćdziesięciosiedmioletnia pacjentka została skierowana do Kliniki Dermatologii z powodu utrzymujących się od 4 lat bolesnych owrzodzeń podudzi. W badaniu klinicznym stwierdzono całkowitą utratę włosów w obrębie skóry głowy, łuków brwiowych, powiek oraz dołów pachowych. Obecne były także przeciwtarczycowe przeciwciała mikrosomalne. Przez ostatnich 15 lat pacjentka okresowo była leczona sulfasalazyną, metotreksatem i metyloprednizolonem z powodu reumatoidalnego zapalenia stawów.

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“…They extracted data from 1546 patients, showing a positive overall association (OR 1.58; CI 95%: 1.02‐2.46; P = .04), even though it was significant only when H pylori infection was detected by IgG serology but not by UBT (OR 0.88; CI 95%: 0.61‐1.27; P = .49) . A meta‐analysis conducted by Lee et al focusing on all possible conditions associated with alopecia areata , included H pylori infection among potential triggers …”

Section: Dermatology and Obstetricsmentioning

confidence: 99%

Review:Helicobacter pyloriand extragastric diseases

2019

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In the last year, many studies have demonstrated a potential role of Helicobacter pylori in the pathogenic mechanisms of different extragastric diseases. While the role of H pylori in idiopathic thrombocytopenic purpura, idiopathic iron deficiency anemia, and vitamin B12 deficiency has already been demonstrated, there is growing evidence of other related conditions, especially cardiovascular, metabolic, and neurologic disorders, including neurodegenerative diseases. A summary of the results of the most relevant studies published over the last year on this attractive topic is presented in this review.

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Comorbidities in alopecia areata: A systematic review and meta-analysis

Cited by 151 publications

References 89 publications

The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

Autoimmune polyglandular syndrome type 4 – case report

Review:Helicobacter pyloriand extragastric diseases

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