Comorbidities in functional gastrointestinal diseases: Do we need a lone ranger or a dream team?

Bellini, Massimo; Gambaccini, Dario; Bassotti, Gabrio

doi:10.1016/j.dld.2016.02.011

Cited by 6 publications

(9 citation statements)

References 16 publications

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“…For the first time, this study analysed the subthreshold psychiatric symptomatology in patients with different FGDs. It also confirmed the previous observations about the high prevalence of Axis I psychiatric disorders among patients with FGD [ 3 , 4 , 9 , 17 , 30 , 36 ], particularly anxiety and mood disorders. Subthreshold psychiatric symptomatology is formed by a variety of symptoms that do not conform to a formal diagnosis of mental disorder according to standard psychiatric classification, but it impacts significantly in quality of life.…”

Section: Discussionsupporting

confidence: 90%

“…5-HT plays a key role in the regulation of visceral pain and in the secretion and initiation of the peristaltic reflex. However, altered levels of 5-HT are also detected in many different psychiatric disorders such as anxiety, depression, obsessive-compulsive disorders, and phobia [ 13 , 17 ]. The 5-HT released in the gut from the enterochromaffin cells regulates the sensory, motor, and secretory functions of the digestive system through interactions with intrinsic and extrinsic nervous pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, they outlined that a multidimensional approach, including both a psychiatric and gastroenterological assessment, is an essential part of an effective management of FGDs. In addition, on the basis of other multidisciplinary care models, a sharp decrease in health care resources should be expected because it could increase the efficacy and efficiency of the disease management, reaching a more rapid diagnosis, accelerating treatment planning, avoiding unnecessary duplication of tests, decreasing the patients' anxiety, and shortening the waiting times for receiving a coordinated plan of care [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?

Stasi

Nisita

Cortopassi

et al. 2017

Gastroenterology Research and Practice

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Background and Aims Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods A total of 135 consecutive patients with FGD were enrolled. The symptoms' severity was evaluated using questionnaires, while the psychiatric evaluation by clinical interviews established the presence/absence of mental (Diagnostic and Statistical Manual—4th edition, Axis I Diagnosis) or spectrum disorders. Results Of the 135 patients, 42 (32.3%) had functional dyspepsia, 52 (40.0%) had irritable bowel syndrome, 21 (16.2%) had functional bloating, and 20 (15.4%) had functional constipation. At least one psychiatric disorder was present in 46.9% of the patients, while a suprathreshold panic spectrum was present in 26.2%. Functional constipation was associated with depressive disorders (p < 0.05), while functional dyspepsia was related to the current major depressive episode (p < 0.05). Obsessive-compulsive spectrum was correlated with the presence of functional constipation and irritable bowel syndrome (p < 0.05). Conclusion The high prevalence of subthreshold psychiatric symptomatology in patients with FGD, which is likely to influence the expression of gastrointestinal symptoms, suggested the usefulness of psychological evaluation in patients with FGDs.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?

Stasi

Nisita

Cortopassi

et al. 2017

Gastroenterology Research and Practice

Self Cite

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“…The most clinically important diseases associated with the serotonin metabolism are gastrointestinal disorders, such as Irritable Bowel Syndrome (IBS), and neurological/psychiatric and hepatic diseases. Serotonin (5-HT) plays a key role in the regulation of visceral pain and secretion and in the initiation of the peristaltic reflex; however, altered levels of serotonin have also been detected in many different psychiatric disorders such as anxiety, depression, obsessive compulsive disorder and phobias [1,2]. Moreover, several evidences [3] have demonstrated the profibrogenic role of 5-HT in the liver, showing that it worked synergistically with Plateletderived Growth Factor (PDGF) in stimulating Hepatic Stellate Cell (HSC) proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, sensitivity and gastrointestinal motility are both regulated by he central and the peripheral nervous systems via the complex interplay existing between the brain and the gut [23]. Several studies have shown a high prevalence of anxiety and mood disorders among IBS patients [2,13,[24][25][26]. On the other hand, low grade inflammation in the intestine may cause the activation of cerebral activity by afferent fibres as a result of the release of interleukin-1 (IL-1), IL-6, tumour necrosis factor-alfa (TNF-alfa) [23].…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between the Serotonin Metabolism, Gut-Microbiota and the Gut-Brain Axis

Stasi

Sadalla

Milani

2019

CDM

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Background:: Serotonin (5-HT) has a pleiotropic function in gastrointestinal, neurological/psychiatric and liver diseases. The aim of this review was to elucidate whether the gut-microbiota played a critical role in regulating peripheral serotonin levels. Methods:: We searched for relevant studies published in English using the PubMed database from 1993 to the present. Results: : Several studies suggested that alterations in the gut-microbiota may contribute to a modulation of serotonin signalling. The first indication regarded the changes in the composition of the commensal bacteria and the intestinal transit time caused by antibiotic treatment. The second indication regarded the changes in serotonin levels correlated to specific bacteria. The third indication regarded the fact that decreased serotonin transporter expression was associated with a shift in gut-microbiota from homeostasis to inflammatory type microbiota. Serotonin plays a key role in the regulation of visceral pain, secretion, and initiation of the peristaltic reflex; however, its altered levels are also detected in many different psychiatric disorders. Symptoms of some gastrointestinal functional disorders may be due to deregulation in central nervous system activity, dysregulation at the peripheral level (intestine), or a combination of both (brain-gut axis) by means of neuro-endocrine-immune stimuli. Moreover, several studies have demonstrated the profibrogenic role of 5-HT in the liver, showing that it works synergistically with platelet-derived growth factor in stimulating hepatic stellate cell proliferation. Conclusion:: Although the specific interaction mechanisms are still unclear, some studies have suggested that there is a correlation between the gut-microbiota, some gastrointestinal and liver diseases and the serotonin metabolism.

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Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

Akram,

Faisal,

Irfan

et al. 2023

Food Science & Nutrition

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Modulatory effects of serotonin (5‐Hydroxytryptamine [5‐HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested that probiotics can promote serotonin signaling, a crucial pathway in the regulation of mood, cognition, and other physiological processes. Reviewing the literature, we find that peripheral serotonin increases nutrient uptake and storage, regulates the composition of the gut microbiota, and is involved in mediating neuronal disorders. This review explores the mechanisms underlying the probiotic‐mediated increase in serotonin signaling, highlighting the role of gut microbiota in the regulation of serotonin production and the modulation of neurotransmitter receptors. Additionally, this review discusses the potential clinical implications of probiotics as a therapeutic strategy for disorders associated with altered serotonin signaling, such as GI and neurological disorders. Overall, this review demonstrates the potential of probiotics as a promising avenue for the treatment of serotonin‐related disorders and signaling of serotonin.

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Comorbidities in functional gastrointestinal diseases: Do we need a lone ranger or a dream team?

Cited by 6 publications

References 16 publications

Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?

Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?

The Relationship Between the Serotonin Metabolism, Gut-Microbiota and the Gut-Brain Axis

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

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