Comorbidities in rosacea: A systematic review and update

Haber, Richard M.; Gemayel, Maria El

doi:10.1016/j.jaad.2017.09.016

Cited by 89 publications

(108 citation statements)

References 46 publications

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“…6,7 Additionally, gastrointestinal microbials including H. pylori and SIBO may be associated with the occurrence of rosacea. Furthermore, although high-frequency dairy product intake only showed a borderline significant effect on rosacea severity after adjusting the covariates in logistic analysis, it showed a significant effect in the crude model (OR = 0.34; 95% CI, 0.12-0.97).…”

Section: Discussionmentioning

confidence: 99%

“…Dairy products may play a role in regulating intestinal microbial flora and reducing the permeability of the intestinal epithelium, causing decreased intestinal inflammation, 37,38 which had been found to be closely associated with rosacea. 6,7 Additionally, gastrointestinal microbials including H. pylori and SIBO may be associated with the occurrence of rosacea. 8,9 Therefore, based on our investigation, we cannot exclude the possibility that dairy products contribute to the prevention and improvement of rosacea.…”

Section: Discussionmentioning

confidence: 99%

“…4 However, the pathophysiology of rosacea is still unknown. 6,7 In addition, several studies suggested a potential relationship between Helicobacter pylori infection, small intestinal bacterial overgrowth (SIBO) and rosacea. 1,5 It is indicated from recent studies that rosacea is associated with many systemic diseases, such as cardiovascular disease, gastrointestinal disorders and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…1,5 It is indicated from recent studies that rosacea is associated with many systemic diseases, such as cardiovascular disease, gastrointestinal disorders and diabetes. 6,7 In addition, several studies suggested a potential relationship between Helicobacter pylori infection, small intestinal bacterial overgrowth (SIBO) and rosacea. 8,9 Based on the potential correlations of these risk factors with rosacea, we investigated the possible involvement of dietary factors in the occurrence and severity of rosacea.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

Yuan

Huang

Wang

et al. 2019

The Journal of Dermatology

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Although patients with rosacea often consult dermatologists for dietary factors that might be related to their skin disorders, few studies have been conducted to research the relationship between rosacea and dietary factors. The purpose of this study was to evaluate the potential relationship between rosacea and diet among the large Chinese population with rosacea, which would provide dietary guidelines for patients with rosacea. A multicenter case–control study was conducted. The feeding frequency 2 years before the occurrence of rosacea was collected by standardized questionnaires. Multiple logistic regression analysis was used to calculate risks related to the diet. One thousand three hundred and forty‐seven patients with rosacea and 1290 controls were enrolled in our study. We found that high‐frequency intake of fatty food and tea presented a positive correlation with rosacea, while high‐frequency dairy product intake showed significant negative correlation with rosacea. Sweet food, coffee and spicy food appeared to be independent of any subset of rosacea in our study. However, high‐frequency dairy product intake showed a borderline beneficial effect on rosacea severity. We further analyzed the correlation between diet and the subtype of rosacea. We found that high‐frequency fatty intake was associated with erythematotelangiectatic rosacea (ETR) and phymatous rosacea, while high‐frequency tea intake was only associated with ETR. In addition, high‐frequency dairy product intake showed negative correlations with ETR and papulopustular rosacea. Rosacea is associated with some dietary factors, and our study is valuable in establishing dietary guidelines to prevent and improve rosacea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

Yuan

Huang

Wang

et al. 2019

The Journal of Dermatology

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“…Together, they activated several unique innate immunity signaling pathways including type I interferon signaling. Systemic activation of these pathways may explain rosacea's association with coronary artery disease and other systemic maladies (Haber and El Gemayel, 2018). These pathways provided the Gallo group with a target list to help elucidate the mechanism of UVRinduced inflammation in rosacea.…”

Section: Targets Of a Rosacea Uvr "Alarmin"mentioning

confidence: 99%

“Shedding Light” on How Ultraviolet Radiation Triggers Rosacea

McCoy

2020

Journal of Investigative Dermatology

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Comorbidities in Autoimmune Skin Diseases

2018

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It may provide deeper insight into the pathomechanisms of both autoimmune skin diseases and their comorbidities and yield valuable suggestions for screening techniques for additional comorbidities that might be integrated into clinical practice. Dermatologists-and in some countries rheumatologists-are most likely be the clinicians who make the diagnosis of many autoimmune diseases.Better awareness about the risk of associated comorbidities could be conducive to both an improved management of patients and to an in-depth understanding of the molecular mechanisms of disease. More epidemiological data are necessary, and systematic reviews on comorbidities should be performed and published regularly to increase this awareness. A website dedicated to comorbidities in dermatology might contribute to this work.

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Comorbidities in rosacea: A systematic review and update

Cited by 89 publications

References 46 publications

Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey

“Shedding Light” on How Ultraviolet Radiation Triggers Rosacea

Comorbidities in Autoimmune Skin Diseases

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