Comorbidity and Physical Function: Results from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study)

Cesari, Matteo; Onder, Graziano; Russo, Andrea M.; Zamboni, Valentina; Barillaro, Christian; Ferrucci, Luigi; Pahor, Marco; Bernabei, Roberto; Landi, Francesco

doi:10.1159/000089822

Cited by 144 publications

(130 citation statements)

References 60 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…36 Functional limitations and disabilities result, primarily, from chronic diseases, 4 and the number of diseases and the interaction between specific diseases, not evaluated in this study, may be important in this relationship. 37 The higher number of diseases may suggest greater medication use and hospitalizations, which associated with aging, and may result in loss of physical function. 38 This study has strengths and limitations.…”

Section: Discussionmentioning

confidence: 99%

Nutritional status, physical performance and functional capacity in an elderly population in southern Brazil

Danielewicz

Barbosa

Duca

2014

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Nutritional status, physical performance and functional capacity in an elderly population in southern Brazil Objective: to investigate the association between nutritional status and functional limitation and disability in an elderly population in southern Brazil. Methods: epidemiological, cross-sectional household-based study carried out with 477 elderly of both sexes (60 to 100 years). Body mass index (BMI) served to assess the nutritional status: underweight (BMI < 22 kg/m²) and overweight (BMI > 27 kg/m²). The sum score (0-5) obtained in three tests: "chair stand" and "pick up a pen" (measured by time) and standing balance (four static measurements) assessed the functional limitation. The disability was evaluated by the difficulty in performing one or more self-reported tasks related to basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs). Crude and adjusted analyzes (3 models) were carried out using Poisson regression; prevalence ratios (PR) and 95% confidence intervals (CI) were calculated. Results: crude analyzes showed a positive association between underweight and functional limitation (PR = 2.71, 95% CI = 1.63 to 4.51); overweight and disability in ADLs (PR = 2.20, CI 95% = 1.44 to 3.35); overweight and disability in IADLs (PR = 1.56, CI 95% = 1.20 to 2.03). The additional adjustments for gender, age, level of education, living arrangements, current work, cognitive function and number of morbidities reduced the strength of the associations, without changing the statistical strength. Conclusion: nutritional status is a factor that is independently and positively associated with functional limitation and disability. We recommend the use of this indicator to monitor the health of the elderly.

show abstract

Section: Discussionmentioning

confidence: 99%

Nutritional status, physical performance and functional capacity in an elderly population in southern Brazil

Danielewicz

Barbosa

Duca

2014

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…Drosophila is emerging as an important model for investigating age-related locomotor impairment, a significant clinical issue for the elderly (Woo et al 1999;Boyd et al 2005;Braam et al 2005;Hillsdon et al 2005;Onder et al 2005;Volpato et al 2005;Cesari et al 2006a;Cesari et al 2006b;von Bonsdorff et al 2006). In flies, negative geotaxis is a commonly used measure for locomotion and its senescence .…”

Section: Discussionmentioning

confidence: 99%

“…Elderly individuals with impaired locomotor abilities are less independent and require more clinical care (Boyd et al 2005), are at much greater risk for being institutionalized (von Bonsdorff et al 2006), and are at greater risk for depression (Braam et al 2005). Additionally, age-related locomotor impairment is associated with increased risk for falling and skeletal fractures as well as a variety of co-morbidities including coronary artery/cerebrovascular disease, obesity, diabetes, and hypertension (Boyd et al 2005;Hillsdon et al 2005;Onder et al 2005;Volpato et al 2005;Cesari et al 2006a;Cesari et al 2006b). Interestingly, one of the key features of locomotor senescence in the elderly population is reduced speed of walking (Oberg et al 1993;Bohannon 1997;Kozakai et al 2000;McGibbon and Krebs 2001;Samson et al 2001;Laufer 2005).Geriatric individuals with reduced walking speed have the greatest locomotor impairment (Brach et al 2007) and consequently are at greater risk for several co-morbidities and death (Woo et al 1999;Hardy et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed

Rhodenizer

Martin

Bhandari

et al. 2008

Experimental Gerontology

118

View full text Add to dashboard Cite

Age-related locomotor impairment in humans is important clinically because it is associated with several co-morbidities and increased risk of death. One of the hallmarks of age-related locomotor impairment in humans is a decrease in walking speed with age. Genetically tractable model organisms such as Drosophila are essential for delineating mechanisms underlying age-related locomotor impairment and age-related decreases in locomotor speed. Negative geotaxis, the ability of flies to move vertically when startled, is a common measure of locomotor behavior that declines with age in Drosophila. Toward further developing Drosophila as a model for age-related locomotor impairment, we investigated whether negative geotaxis reflects climbing or a combination of climbing and other behaviors such as flying and jumping. Additionally, we investigated whether locomotor speed in negative geotaxis assays declines with age in flies as found for walking speed in humans. We find that the vast majority of flies climb during negative geotaxis assays and that removal of hind legs, but not wings, impairs the behavior. We also find that climbing speed decreases with age in four wild type genetic backgrounds, in flies housed at different temperatures, and in control and long-lived flies harboring a mutation in OR83b. The decreases in climbing speed correlate with the age-related impairments in the distance climbed. These studies establish negative geotaxis in Drosophila as a climbing behavior that declines with age due to a decrease in climbing speed. Agerelated decreases in locomotor speed are common attributes of locomotor senescence in flies and humans.

show abstract

“…The physical-functional tests were: timed up and go test 36,37 , five step test 38 , right and left one-leg balance time 39 , short physical performance battery (SPPB) [40][41][42][43] , and habitual gait velocity.…”

Section: Anmentioning

confidence: 99%

Tontura em idosos da comunidade: estudo de base populacional

Moraes¹,

Soares²,

Rodrigues³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

View full text Add to dashboard Cite

Dizziness is a common complaint among older adults. Aim To identify the prevalence of dizziness and its related factors in a sample of community-dwelling older adults. Methods A prospective population-based study with a representative sample of older adults aged 65 years and over. A multidimensional questionnaire and a battery of measures were used for assessing physical function. Results The prevalence of dizziness was 45%. Vertigo was found in 70.4% of older adults with dizziness and 43.8% of them referred vertigo crises along life. A significant association was found between dizziness and female gender ( p =0.004), memory difficulties complaints ( p =0.015), bad health perception ( p =0.001), depression ( p <0.0001), five or more comorbidities ( p =0.021), self-reported fatigue ( p <0.0001), recurrent falls ( p =0.001), excessive sleepiness ( p =0.003), fear of falling ( p <0.0001), left leg unipedal stance ( p =0.002) and Short Performance Physical Battery score ( p =0.009). Conclusion Dizziness is a common complaint among older adults and it is associated with limiting clinical conditions, such as depression, fatigue, excessive sleepiness and impaired memory. It is highlighted the association between dizziness and recurrent falls, fear of falling and lower performance in physical function tests, which can restrict independence. These data suggest the importance of a multifactorial approach to dizziness in older adults.

show abstract

Comorbidity and Physical Function: Results from the Aging and Longevity Study in the Sirente Geographic Area (ilSIRENTE Study)

Cited by 144 publications

References 60 publications

Nutritional status, physical performance and functional capacity in an elderly population in southern Brazil

Nutritional status, physical performance and functional capacity in an elderly population in southern Brazil

Genetic and environmental factors impact age-related impairment of negative geotaxis in Drosophila by altering age-dependent climbing speed

Tontura em idosos da comunidade: estudo de base populacional

Contact Info

Product

Resources

About