2017
DOI: 10.1111/ped.13323
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Comorbidity and quality of life in childhood cancer survivors treated with proton beam therapy

Abstract: CCS who were treated with multimodal treatment using PBT had a higher QOL score. Higher score was related to longer time since treatment, regardless of comorbidity.

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Cited by 18 publications
(28 citation statements)
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“…Although those children mainly received oral TKIs, which were different from other cancer patients requiring intensive chemotherapy in hospital, we found some variables, including female gender and age, were associated with HRQoL. This is consistent with the previous studies about HRQoL of children with other cancers [4,6,8,[10][11][12]14] . Just as adult CML, TKI-related symptoms reported was the variables correlated with impaired HRQoL.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Although those children mainly received oral TKIs, which were different from other cancer patients requiring intensive chemotherapy in hospital, we found some variables, including female gender and age, were associated with HRQoL. This is consistent with the previous studies about HRQoL of children with other cancers [4,6,8,[10][11][12]14] . Just as adult CML, TKI-related symptoms reported was the variables correlated with impaired HRQoL.…”
Section: Discussionsupporting
confidence: 91%
“…Many studies showed that children with cancer had worse HRQoL when compared with healthy children. Female gender, living alone, severity of the malignant disease, high intensive treatment and poor response to treatment had a negative impact on HRQoL in childhood cancer survivors [4][5][6][7][8][9][10][11][12][13][14] . Meanwhile, higher education and better communication with parents are related to higher HRQoL [15][16][17] .…”
Section: Introductionmentioning
confidence: 99%
“…7 Fukushima et al reported two patients with secondary neoplasms (one with breast cancer 10 years after initial therapy and one with meningioma within the radiation field 12 years after PBT). 5 In the present cohort, one patient developed osteosarcoma in the radiation field as a secondary malignancy (case 5) 38 months after diagnosis (32 months after PBT). The median observation period in Rombi's study (38.4 months (range, 17.4 months to 7.4 years)) was similar to that in the present study, in which the median observation period was 52 months (range, 12 to 90 months).…”
Section: Discussionmentioning
confidence: 63%
“…Fukushima et al reported that the quality of life of childhood brain/head and neck tumor survivors treated with PBT was similar to that of healthy controls and favorable compared to patients treated with photon beam therapy. 5 In Japan, PBT for childhood malignant solid tumors has been approved by the public health insurance system since April 2016. Although 13 institutions can provide PBT in Japan, only four institutions have treated children.…”
Section: Introductionmentioning
confidence: 99%
“…By contrast, PBT appears to substantially reduce late radiation complications because grade ≥2 and ≥3 late toxicities were 35% and 17% at 10 years and 45% and 17% at 20 years, respectively [ 41 ]. Fukushima et al [ 27 ] followed 60 patients 15 years or younger treated between 1983 to 2011 with PBT. A total of 32% (19 of 60) of patients had ≥1 grade ≥3 toxicity, most commonly associated with facial deformities and/or central nervous system damage.…”
Section: The Benefit Of Proton Rt In Reducing Radiation-induced Toxicitiesmentioning
confidence: 99%