Comorbidity of arterial hyperten­sion and tension-type headache

Abstract

Arterial hypertension (AH) and exertional headache (EHA) are comorbidities. The article presents a nonsystematic review focused on studying the AH+EHA phenotype. The authors addressed the history of studying the phenotype, several theories about its pathophysiological causes (psychosomatic, neuroanatomical, and baroreflector). The protective “hypertension-associated hypoalgesia” phenotype, a mechanism of its change in AH chronization, and difficulties of differential diagnosis are described. The AH+EHA phenotype requires further study since its incidence is quite high. This will allow developing an individualized approach in prevention and treatment of EHA attacks, decreasing the risk of life-threatening cardiovascular complications, and avoiding iatrogenic complications in patients with AH. The main way to prevent the development of AH+EHA phenotype is patient’s compliance, which can be provided by using combination hypotensive drugs to reduce the number of pills and dosing. It is important to take into account possible adverse reactions of the nervous system (medication-overuse headache or EHA aggravation). Considering these conditions, the drug Triplixam can be used for prevention of complications in the AH+EHA phenotype. Triplixam is a fixed triple combination of amlodipine/indapamide/perindopril, and its individual components have low and medium risk for development of headache.

Association between Dietary Fiber Intake and Incidence of Depression and Anxiety in Patients with Essential Hypertension

“…They were selected via tick boxes by patients. Comorbidity referred to the co-existence of one or more diseases or clinical conditions and is independent of blood pressure [27]. When the patient cannot determine whether his disease was a complication, the research team asked the patient for medical history to make a decision.…”

The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension

“…psychogenic mechanism (stress, anxiety, and psycho-emotional fatigue can provoke both the development of a M attack [42,43] and an episode of increased blood pressure [44,45]); -vascular mechanism (vasodilation is one of the leading mechanisms for the development of M [46], and some antihypertensive drugs can cause excessive vasodilation of cerebral arteries and veins, leading to the development of migraine-like H [47]); -biochemical mechanism (for example, NO-dependent vasospasm (impaired NOdependent vasodilation) [46,48]).…”

Effect of Dietary Fiber (Oat Bran) Supplement in Heart Rate Lowering in Patients with Hypertension: A Randomized DASH-Diet-Controlled Clinical Trial

“…They were selected via tick boxes by patients. Comorbidity referred to the co-existence of one or more diseases or clinical conditions and is independent of blood pressure [ 32 ]. When the patient cannot determine whether his disease was a complication, the research team asked the patients of medical history to make a decision.…”